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Biomedical subjects

S Jimi

Publications and source records attributed to S Jimi.

At least 91 records · Page 5Linked to original sources
PubMed1983

Decreased mortality among relatives of patients with systemic lupus erythematosus.

The authors studied mortality among 2513 relatives of 56 Japanese patients with systemic lupus erythematosus. The observed deaths in 142 relatives were compared with the expected number of deaths. The observed number of deaths was significantly less among relatives of patients with systemic lupus erythematosus (p less than 0.01). Deaths from malignant neoplasms and senility (senescence) were significantly lower than the expected number of deaths among relatives (p less than 0.05).

Autoantibodies↗
PubMed1983

Effects of immunostimulants on the in vitro generation of cytotoxic lymphocytes against cervical cancer cell lines.

Human peripheral blood lymphocytes were sensitized in vitro against cervical cancer cell lines and the effect of immunostimulants, such as BCG, streptococcal preparation (OK-432), yeast cell wall, and Concanavalin A, on the generation of cytotoxic lymphocytes was examined. The cytotoxic activity of sensitized lymphocytes was augmented by the addition of OK-432 (0.01 KE/ml) during in vitro sensitization, but the induction of sensitized lymphocytes was inhibited by the addition of yeast cell wall (10 micrograms/ml). When the lymphocytes from cervical cancer patients free from tumor after surgical operation were stimulated on the autologous tumor cell monolayer, the cytotoxic lymphocytes could be generated. In vitro primed lymphocytes could be reactivated following the stimulation with OK-432 (0.01 KE/ml) for 48 hr and the requirement for a proliferative trigger seems to be important for the in vitro generation of cytotoxic lymphocytes. The role of nonspecific stimulation by LD-like products in the in vitro generation of cytotoxic lymphocytes was discussed.

Adjuvants, Immunologic↗
PubMed1983

Circulating immune complexes in Behçet's disease.

The levels of circulating immune complexes (CICs) were investigated in the patients with Behçet's disease by Clq solid-phase enzyme immunoassay. A significantly higher level of CICs was observed in the patients than in the control group. Concerning the correlation between the levels of CICs and the stages of the ocular attack, the levels were significantly higher in the preattack stage and the early stage of the attack than in the late stage and the remission phase. A high level of CICs was associated with the patients of the fulminant form of ocular attacks. These results suggest that immune complexes may play a role in the development of the ocular attack of Behçet's disease.

Adult↗
PubMed1982

Phagocytosis-connected oxygen consumption by peripheral leukocytes from patients with systemic lupus erythematosus.

The phagocytic activity of peripheral blood leukocytes was assayed by means of oxygen consumption in 28 patients with systemic lupus erythematosus (SLE) and 22 normal individuals. The method in which zymosan was added to a small volume of whole blood enabled us to assay quantitatively and rapidly both the phagocytosis-connected oxygen consumption and the opsonizing time. The degree of oxygen consumption by phagocytes from SLE patients was not significantly different from that in normals. Opsonizing time of zymosan by autologous serum in SLE patients did not differ from that in normals either. It should be emphasized, however, that the opsonizing time of zymosan in SLE patients was inversely correlated with serum complement level, especially C3 level (coefficient of correlation = -0.76, p less than 0.001). This raises the possibility that the phagocytosis may be delayed in SLE patients with low titers of C3.

Adolescent↗
PubMed1982

[FT-207 maintenance therapy of malignant gynecologic cancer].

Maintenance treatment with FT-207 was applied to 92 patients with uterine cancers after initial treatments were performed. Daily dosage of FT-207 was either 600 or 800 mg and the drug was administered orally. The duration of 6 months and the total dosage of 100 g were proposed as administration schedule and 34 patients (37%) received this regimen. Side effects during the treatment were observed in 35 cases (38%). Gastrointestinal disturbance was most frequently observed and other side effects included myelosuppression, general fatigue, hepatic dysfunction and skin toxicities. There were no serious side effects, the treatment was continued in most patients and was interrupted only in 7 cases (8%). In the cases of recurrence or advanced cancer, however, the side effect was the predominant cause for interruption of administration. As for the antitumor effect of the treatment, a survival rate of the patients with cervical cancer of early stages was evaluated. Three-year survival rate in the treatment group was higher comparing to the one reported hitherto.

Antineoplastic Agents↗
PubMed1981

Elevated cytostatic activity of monocytes from cancer patients.

Cytostatic activity of peripheral blood monocytes from patients with head and neck cancer, gastro-intestinal cancer, uterine cervical cancer, benign tumors of the head and neck, inflammatory diseases and pulmonary tuberculosis was studied by using a cultured lymphoid cell line as the target cell. Significantly higher cytostatic activities were observed at an effector-target cell ratio of 5:1 in these patients (except for pulmonary tuberculosis patients) than in healthy controls. The cytostatic activity of the monocytes from gastric cancer patients was more elevated in advanced stages than in stage 1. The cytostatic activity of culture supernatants of monocytes from cancer patients did not differ from that of healthy controls. The activity of the monocytes following radiation therapy combined with chemotherapy in patients with head and neck cancer was depressed. The significance of elevated cytostatic activity of monocytes in cancer patients is discussed.

Animals↗
PubMed1979

Antibody-dependent cell-mediated cytotoxicity of sera from cancer patients against cultured cervical cancer cell lines.

Cytotoxicity of sera from cervical cancer patients mediated by peripheral blood lymphocytes against cervical cancer cell lines was studied. Percentages of reduction of target QG-K by sera from healthy controls and cervical cancer patients were 4.7% and 32.0%, respectively. Sera from patients with pulmonary tuberculosis also exhibited antibody-dependent cell-mediated cytotoxicity (ADCC) against the cells. Especially, high degree of activity was observed in the sera from patients with stage IV and the activity decreased to the control level in recurrent cases. The titer of the sera varied against different target cell lines, and the activity was found even at 1:10(4) dilution of the sera. These activities remained after absorption of the serum with other tumor cells. Complement-dependent cytotoxic activity of the sera was not observed. The meaning of the cytotoxic activity of the sera from cervical cancer patients was discussed.

Antibodies, Neoplasm↗
PubMed1978

Lymphotoxin production in cancer patients: possible relation to blastogenesis and the degree of tumor disease.

Peripheral blood lymphocytes from healthy donors, cancer patients, and noncancer patients were cultured with or without phytohemagglutinin (PHA) for 3 days, supernatant containing lymphotoxin (LT) was added to L cells, and LT activities were examined. LT release by PHA-stimulated lymphocytes from patients with uterine cervical cancer in stages 0 and I decreased and the degree of the decrease was much more marked in stage IV. However, LT activities released spontaneously without PHA were higher in patients with uterine myoma, patients with uterine cervical cancer in stages II to IV, patients with pulmonary tuberculosis, and patients with gastro-intestinal cancer. Relation of LT release and blastogenesis following stimulation with PHA was also examined. Correlation was observed in only 14 out of 43 patients with uterine cervical cancer (32.6%). The role of LT in cancer patients was discussed.

Female↗
PubMed1977

Cell-mediated cytotoxicity in vitro of human lymphocytes against a cervical cancer cell line.

Peripheral blood lymphocytes from patients with uterine cervical cancer were tested against a cervical cancer cell line by micro-cytotoxicity assay. In stage O, high degree of cytotoxicity was observed but it decreased with progression of disease. In stage IV and recurrent cases, cytotoxic activity was negligible. Lymphocytes from healthy controls and myoma patients were not cytotoxic against target cells. On the other hand, lymphocyte response of phytohemagglutinin as a nonspecific T-cell activity was as high as the of healthy control in stage O, but the response decreased in stages I to IV and recurrent cases. In stages I to III, several cases showed cytotoxic activity but decreased response to phytohemagglutinin.

Carcinoma↗