[67Ga-scintigraphy in patients with malignant tumors].
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Biomedical subjects
Publications and source records attributed to S Jinnouchi.
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The use of liver and hepatobiliary scintigraphy for evaluation of the hepatobiliary system in patients with hepatic disease is now widespread. In the present case, the usefulness of liver and hepatobiliary scintigraphy for the diagnosis of liver malformation is described.
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Organ volume was experimentally and clinically determined using single photon emission computed tomography (SPECT). In organ phantom filling with 99mTcO4-, the error was less than 3.3% in the volume over 400 ml but 11% at 200 ml. In 28 cases of patient, liver and spleen volume were measured by SPECT and X-CT. Good correlation was founded between SPECT volume and X-CT volume (r = 0.99, n = 49), although SPECT volume were 16% higher than X-CT volume (y = 1.16 x + 11.6, x: X-CT volume, y: SPECT volume).
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Serum ferritin levels were studied in 264 patients who were consisted of 153 patients with various malignant neoplasms and 111 patients with various benign diseases. Positive rate of serum ferritin in all patients with malignant neoplasms was 35%. Hepatomas and pulmonary cancer showed relatively high positive rate, respectively 65% and 42%. In patients with benign diseases, hepatic diseases showed the high positive rate (52%) and the other benign diseases was low positive rate (11%). The relationship between serum ferritin and alpha-feto-protein in patients with hepatomas and other liver diseases was low. And the relationship between serum ferritin and CEA (carcinoembryonic antigen) in patients with malignant neoplasms of gastrointestinal tract was also low. It seemed that the measurement of serum ferritin levels will be of low value in the differentiation of the patients with malignant neoplasms.
Fifty-four patients with carcinoma of the cervix uteri were treated with external irradiation and high-dose intracavitary irradiation according to their clinical stage. The 4-year relative survival rate was 86.6% in stage I patients, 77.9% in stage II, 55.4% in stage III and 0% in stage IV. The incidence of radiation injury was: perforation of the intestine, 2 cases; vesico-vaginal fistula, 2 cases; recto-vaginal fistula one case; stenosis of the rectum or sigmoid, 2 cases. This suggests that severe complications may occur in reirradiated cases or cases irradiated with more than 7 fractions of intracavitary irradiation. The optimal radiation dose seemed to be 2,400 to 3,000 rad at point A with a fraction dose of 600 rad a week, combined with whole pelvis irradiation of 3,000 to 4,000 rad.