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Biomedical subjects

S K Ali

Publications and source records attributed to S K Ali.

12 recordsLinked to original sources
PubMed2000

Subcutaneous panniculitic T cell lymphoma mimicking histiocytic cytophagic panniculitis in a child.

Subcutaneous panniculitic T-cell lymphoma is a very rare malignancy in the pediatric age group, its association with hemophagocytic syndrome had been described but the association with the skin lesions mimicking histiocytic cytophagic panniculitis which is characteristic of hemophagocytic syndrome has not, to our knowledge, been described in children. We report a child with panniculitic T-cell lymphoma associated with bone marrow hemophagocytosis and subcutaneous histiocytic infiltration with active phagocytosis simulating histiocytic cytophagic. We stress the importance of searching for T-cell lymphoma in patients with panniculitis and hemophagocytic syndrome.

Biopsy, Needle↗
PubMed1985

Immunocytochemical investigation of carcinoembryonic antigen expression in neuroblastoma with monoclonal and polyclonal antibodies.

Immunocytochemical localization of two monoclonal anticarcinoembryonic antigen antibodies (11-285-14; 11-359-6) which recognize different CEA epitopes, and a polyclonal anti-CEA antibody (DAKO) recognizing both carcinoembryonic antigen and nonspecific cross-reacting antigen, was studied in 59 tumor tissue samples from 18 patients with neuroblastoma. No evidence of intact tumor cell staining was seen with any of the antibodies although the polyclonal antibody often stained necrotic tissue and infiltrating inflammatory cells. It is concluded that at the level of sensitivity of immunocytochemical localization, neuroblastoma cells do not express carcinoembryonic antigen.

Adolescent↗
PubMed1984

Familial intracranial gliomas.

The pedigree of two interrelated families with 10 affected members suffering from malignant supratentorial gliomas is reported. In addition, three other unrelated families with two members each who were treated for different types of brain tumors are described. Genetic implications are discussed.

Adolescent↗
PubMed1982

Acute renal failure in an infant with congenital neuroblastoma - successful treatment by hemodialysis.

Acute renal failure developed in an infant aged 30 days during chemotherapy and irradiation for hepatic neuroblastoma (IV-S). Acute hemodialysis via a profunda femoris - long saphenous vein shunt was accomplished on 9 occasions in this 4 kg infant. The complications of septicemia and acute respiratory embarrassment caused by hepatomegaly were treated by appropriate antibiotic treatment, creation of a temporary ventral hernia and assisted ventilation. Careful attention to correct pediatric hemodialysis technique, as described, can permit long-term survival if the underlying disorder is also amenable to treatment.

Acute Kidney Injury↗
PubMed1977

Thymus-dependent lymphocytes and delayed hypersensitivity in low birth weight infants.

The proportion of thymus-dependent (T) lymphocytes in the blood and the ability to mount cutaneous delayed hypersensitivity to a battery of antigens were evaluated in 50 low birth weight (LBW) infants when they were 3 months to 5 years old. There was a significant reduction in the number of T lymphocytes. Delayed hypersensitivity was impaired. The abnormalities were more pronounced in those with persistent growth retardation. It is suggested that continued postnatal depression of cell-mediated immunity in LBW infants may contribute to increased frequency of infections and immunopathological diseases.

Child, Preschool↗
PubMedDate not supplied

Eulogy for Amanda.

Explore the source record for details and available documents.

Attitude to Death↗
PubMedDate not supplied

Toxicity of 3'-deamino-3'-(3-cyano-4-morpholinyl) doxorubicin and doxorubicin in nude mice bearing human tumour xenografts.

The toxicity of the intensely potent anthracycline 3'deamino-3'-(3-cyano-4-morpholinyl)doxorubicin (MRA-CN) has been evaluated in nude mice bearing human colonic cancer xenografts. In addition to dose related toxicity manifested as weight loss and effects on the haematology profile, we obtained evidence of cardiotoxicity with MRA-CN, which has not been reported previously. Even a single dose of 0.012 mg kg-1 could induce significant myocardial changes as seen by electron microscopy. Our results suggest that nude mice bearing human tumour xenografts may offer a very sensitive model for the evaluation of anthracycline induced cardiomyopathy. In view of the potential of MRA-CN in cancer treatment, these results need to be confirmed and extended.

Animals↗