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Biomedical subjects

S K Angra

Publications and source records attributed to S K Angra.

At least 19 recordsLinked to original sources

Pre-existing posterior capsule breaks from perforating ocular injuries.

We analyzed the characteristic features and intraoperative behavior of pre-existing posterior capsule breaks in 12 cases of traumatic cataract caused by perforating ocular trauma. The interval between the occurrence of trauma and cataract surgery ranged from three days to one year. Two distinct types of posterior capsule breaks were found: one had thick, fibrous, opaque margins with associated posterior capsule opacification (type I); the other had thin, transparent margins (type II). Type I breaks did not enlarge intraoperatively, whereas type II breaks behaved as fresh breaks by enlarging during irrigation/aspiration and had to be managed by viscoelastic plugging, dry aspiration, and adequate vitrectomy. Primary posterior capsulectomy was required in all cases with type I breaks because of posterior capsule opacification. The difference in the two types of breaks appeared to be time-dependent: cases with delayed surgical intervention (one month to one year) showed type I breaks with clinical evidence of attempted healing of the defect; cases with early surgical intervention (three days to one week) exhibited type II breaks, which did not differ from fresh intraoperative breaks.

Adult

Nd:YAG "sweeping"--an indirect technique for clearing intraocular lens deposits.

Corticosteroid-resistant deposits on the anterior surface of intraocular lenses (IOLs) in 11 patients who had complained of poor vision were "swept" with a Neodymium:YAG laser beam. As contrasted with previous "direct hit" methods, our method is indirect, using a low-power, defocused beam to generate an acoustic shock-wave, which then sweeps the lens surface clear of deposits. The deposits were cleared in all 11 patients, with no damage to the IOL or any other postlaser complications. Improvement in visual acuity ranged from 1 to 3 lines, and all the patients reported alleviation of symptoms.

Adolescent

Direct scleral fixation of posterior chamber intraocular lenses using a special needle-holder.

We report a modified technique of direct scleral fixation of a posterior chamber intraocular lens (PC-IOL) using a specially designed intraocular needle-holder. The procedure was carried out in three eyes with posttraumatic subluxated cataracts; one with aphakic bullous keratopathy and with an accidental posterior capsular rent, and one with a superior zonulodialysis. The needle-holder greatly facilitated the procedure, enabling us to place the PC-IOL precisely in the ciliary sulcus with no subsequent decentration. This method avoids iris fixation and provides more secure scleral fixation of the PC-IOL.

Adult

Efficacy of cryotherapy in vernal catarrh.

Cryotherapy of the palpebral conjunctiva with oral aspirin has been evaluated in mixed-type active vernal keratoconjunctivitis. The symptoms and signs were recorded on a four-point scale. In 15 patients, we used cryotherapy of the palpebral conjunctiva in 30 eyes (-60 degrees C to -80 degrees C for 30 seconds, repeating the freeze-thaw cycle 2-3 times). All patients received oral aspirin 0.5 to 1.5 g in three divided doses daily over six weeks. The relief from symptoms was statistically significant (P less than .001). Objective improvement (palpebral and bulbar signs) also was statistically significant (P less than .001). Follow-up of these cases for one year showed a 3.3% recurrence rate.

Adolescent

Pseudophakic pupillary-block glaucoma in children.

We studied 16 children, ranging in age between 3 and 8 years, who had posterior chamber intraocular lens implantation and developed inflammatory pupillary-block glaucoma. Prophylactic peripheral iridectomy had not been performed in any of the eyes. The patients were treated medically, and YAG laser iridotomy was performed successfully one week after initial control of intraocular pressure. Of 16 eyes in which intraocular pressure remained uncontrolled, trabeculectomy was necessary in three eyes and irreversible glaucomatous visual loss occurred in two eyes. Our data demonstrate the need for stringent and more frequent postoperative follow-up of children after intraocular lens implantation, especially during the first four postoperative weeks. Careful long-term follow-up for treatment after cataract is mandatory to prevent development of amblyopia.

Acetazolamide

Topical norfloxacin therapy in Pseudomonas corneal ulceration.

We treated 12 eyes with Pseudomonas ulcerative keratitis with topical 0.3% Norfloxacin drops (Ranbaxy Laboratories). Excellent response was achieved in all eyes, resulting in complete ulcer resolution. The healing time varied from 12 to 20 days. There was a marked improvement over the pretreatment visual acuity in 11 of the 12 eyes. No systemic or ocular side effects were observed during the study period. The present study strongly suggests that topical norfloxacin is a potent and effective drug in the treatment of Pseudomonas ulcerative keratitis.

Administration, Topical

Contact thermal burns of the cornea.

The records of 59 patients (66 eyes) with contact thermal burns of the cornea (unilateral in 52 cases and bilateral in 7) were reviewed to determine the causes, clinical presentation, management and complications of such injuries. Most of the injuries (90%) occurred at home. The commonest cause was splashing of boiling fluids (42% of cases), followed by contact with red-hot firecracker particles (18%) and lit match heads (17%). In 59 eyes (89%) the burn was limited to the corneal epithelium, in 5 (8%) the superficial stroma was also involved, and in 2 (3%) there was associated corneal perforation caused by mechanical impact of foreign bodies. Débridement of the coagulated epithelium with patching was the most successful treatment, healing 48 (73%) of the eyes. Postburn complications were rare, the most common being development of inferior symblepharon, in three eyes (4%).

Adolescent

Types of posterior capsular breaks and their surgical implications.

We studied the pathogenesis, clinical features, and management of posterior capsular breaks in 28 cataract patients during planned extracapsular cataract extraction and intraocular lens implantation surgery. In the age-related cataract group (17 cases), the posterior capsular breaks were fresh, caused by the irrigation-aspiration cannula. Located in the upper part of the posterior capsule, they had thin margins and tended to enlarge with continued irrigation. Nine (52.9%) of these breaks could be plugged with viscoelastic, and after dry aspiration, a posterior chamber lens was implanted successfully. Posterior capsular breaks in traumatic cataracts (11 cases) were preexisting but were detected only during surgery. Centrally located, they had thick fibrosed margins and remained the same size during irrigation- aspiration. The minimal vitreous herniation seen in four (35.3%) of these cases was managed by automated partial anterior vitrectomy through the break. A posterior chamber intraocular lens was implanted in all these cases.

Adolescent

India-US case-control study of age-related cataracts. India-US Case-Control Study Group.

In a hospital-based case-control study of 1441 patients with age-related cataracts and 549 controls, we studied associations between types of cataract--nuclear, cortical, posterior subcapsular, and mixed--and a number of physiologic, behavioral, environmental, and biochemical variables. Using polychotomous logistic regression analysis, we found an increased risk of cataract with lower educational achievement (all types of cataract), decreased cloud cover at place of residence (all types), use of aspirin less than once a month (posterior subcapsular and mixed), diets low in selected nutrients (posterior subcapsular, nuclear, and mixed), higher blood pressure (nuclear and mixed), lower body mass index (nuclear and mixed), use of cheaper cooking fuels (cortical, nuclear, and mixed), and lower levels of an antioxidant index based on red blood cell levels of glutathione peroxidase and glucose-6-phosphate dehydrogenase and plasma levels of ascorbic acid and vitamin E (posterior subcapsular and mixed). All risks cited were significantly different from those for the other cataract types, a finding that emphasizes the need to investigate the epidemiology of specific types of cataract.

Adult

Microbial contamination of donor eyes.

A total number of 1,516 donor eyes received from various sources during the years 1973-1985 were subjected to the isolation of bacterial contamination. The bacterial cultures taken from the pretreatment eyeball showed culture growth in 366 (24.1%) eyes. Of the 366 positive cultures, 331 (21.8%) were bacterial and 35 (2.3%) were fungal. Amongst the bacterial the major contamination was by staphylococcus aureus and albus and pseudomonas aeruginosa. Gentamicin was found to be the most sensitive antibiotic against a wider group of organisms, the next being chloramphenicol. Thus, treatment of a cadaver eye with a solution of normal saline containing 0.1-0.5 mg/ml of gentamicin is recommended before and after the donor eye is enucleated.

Adolescent

Genetic appraisal of congenital cataract.

A total of 45 congenital cataract cases were studied for chromosomal aberrations and dermatoglyphic patterns. Whereas parents showed no marked differences, patients showed marked differences in different dermatoglyphic traits as compared to age-sex matched controls. Out of all the patients Rubella, hereditary and undetected actiology groups showed variations differently, SCE were seen in all cataracts irrespective of their aetiology as compared to controls.

Cataract

Pseudo-achondroplastic variant of multiple epiphyseal dysplasia with cataract and vitiligo.

Multiple epiphyseal dysplasias may present as congenital or late-onset (tarda) forms or as the variant pseudo-achondroplastic type. While the association between cataract and skin anomalies is well known in the congenital type, it has not been reported for the late-onset type of multiple epiphyseal dysplasia. A 5 1/2-year-old child with the pseudo-achondroplastic variant of multiple epiphyseal dysplasia has been observed to have the unusual association of cataracts and vitiligo, a condition which lacked previous documentation.

Cataract