Enzymatic and structural studies of human cardiac myosin from young and old subjects have been investigated to determine possible changes in myosin properties in aging hearts. Human ventricular myosin from old subjects (47-70 years old) has lower actin-activated ATPase activity than and increased alkaline sensitivity as compared to myosin from young subjects (1-132 months old). Ca2+-and K+(EDTA)-ATPase activities, pyrophosphate gel patterns and one-dimensional peptide mapping of heavy chains of ventricular myosin from old subjects are similar to those observed for myosin from young subjects. Atrial myosin from human hearts differs significantly from ventricular myosin in that the Ca2+-, Mg2+- and actin-activated myosin Mg2+-ATPase activities of atrial myosin are significantly higher than those of ventricular myosin. Pyrophosphate gel electrophoresis patterns and peptide mapping of heavy chains of atrial myosin are also different from those of ventricular myosin. Unlike ventricular myosin, atrial myosin from young hearts is similar to that of atrial myosin from old hearts in its enzymatic and structural properties.

Adenosine Triphosphatases↗

PubMedDate not supplied

Nmr studies of colchicine and its photoisomers, beta- and gamma-lumicolchicines.

Unambiguous 1H- and 13C-nmr assignments of colchicine, beta-lumicolchicine, and gamma-lumicolchicine have been obtained using a combination of 1D- and 2D-nmr spectroscopic techniques. The data indicate that gamma-lumicolchicine is a stereoisomer of beta-lumicolchicine and provide definitive evidence for their stereochemical assignments.

Colchicine↗

PubMedDate not supplied

Bilateral jaw-winking (Marcus Gunn's phenomenon) (a case report).

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Blepharoptosis↗

PubMedDate not supplied

Prevalence of toxoplasmosis in Calcutta and suburbs--a hospital based study for three years.

A total of 752 subjects were tested randomly for detection of antitoxoplasma antibody and its titre. Of these 752 subjects, 170 i.e. 22.6% showed seropositivity for antitoxoplasma antibody. However the titre varied between 1:2 to 1:1024, but in most cases its was 1:128.

Antibodies, Protozoan↗