PubMed Health⌕ Search

Biomedical subjects

S K Chirkova

Publications and source records attributed to S K Chirkova.

14 recordsLinked to original sources
PubMed1993

[The behavioral and neurohormonal manifestations of emotional stress states in monkeys].

Under the effect of intense stressful stimuli baboons developed a depressive state. The disintegration of individual and social behaviour correlates with changes in functional activity of steroid-producing glands and the dynamics of the blood endorphin concentration, thus suggesting involvement of the opioid peptide system and the hypophyseal-gonadal complex in mechanisms of stress-induced depressive states.

Acute Disease↗
PubMed1992

[Stress-inducing behavioral changes and the functions of the neurohormonal systems in monkeys of different social ranks].

As a result of intensive stressful stimuli hamadryas baboons developed, depending on their hierarchic status, depression-like states varying in severity. Their development correlated with a drastic release of biogenic amines, activation of pituitary-adrenal system and inhibition of hormonal function of the gonads. It is shown that dominant and low-rank monkeys, in spite of the differences in their initial psychoemotional states and in the blood levels of mediators and hormones, demonstrated marked disintegration in their individual and social behavior. There was a larger increase in the blood concentrations of dopamine, serotonin and cortisol and more significant inhibition of testosterone production under the influence of two-hour immobilization as compared to the subdominant animals.

Animals↗
PubMed1989

[A decrease in the content of immunoreactive alpha- and gamma-endorphins in the blood and the suppression of their hypersecretion under the influence of dexamethasone in emotional stress in monkeys].

Daily administration of 12 mg of dexamethasone to monkeys during 10 days resulted in decrease of the levels of alpha- and gamma-endorphins and cortisol 7 days after the first injection. The titers of these peptides in plasma of monkeys. exposed to two hours of immobilization stress were elevated twice above basal levels. The maximum elevation took place 6 hours after the beginning of immobilization. This effect wasn't detected in monkeys, which received 12 mg of dexamethasone during 10 days.

Acute Disease↗
PubMed1988

[The nature of the neurohormonal reorganizations in patients with neuroses].

Neurohormonal balance was studied in patients suffering from neurasthenic, hysteric of obsessive-phobic neuroses. The peculiarities of functional restructuring in sympathoadrenal, opioid and pituitary-adrenal cortex systems were considered as related to clinical form or stage of the disease. Irrespective of the neurosis clinical form, a considerable rise in the endorphin blood levels with increasing sympathoadrenal and adrenocortical activities were typical of its initial stages. With long-lasting neuroses, the neurohormonal shifts characteristic of chronic emotional stress were detected.

Adult↗
PubMed1987

[Psychopathological and hormonal manifestations of alcoholic intoxication and emotional stress in monkeys].

Ethological approach to studying mature P. hamadryas and M. mulatta males has revealed a wide spectrum of changes in individual and zoosocial behaviour in response to the administration of different alcohol doses and stress stimuli. It has been established that neuroendocrine basis for the depression of psychic and locomotor activities developing in conditions of alcohol intoxication and emotional stress is an extremely high release of catecholamines and the increase of glucocorticoid secretion accompanied by a sharp decrease in androgen products. It should be noted that the exposure to stress stimuli during consumption of small alcohol doses intensifies depression-like stress-induced behaviour of monkeys.

Alcoholic Intoxication↗
PubMed1986

[Role of the monoaminergic system and steroid-producing glands in the development of emotional stress and the pathogenesis of arterial hypertension in monkeys].

Radioimmune assays of blood cortisol and testosterone levels were carried out in mature and prepubertal male baboons exposed to repeated immobilization stress. Sympathoadrenal activity was assessed on the basis of total daily urinary catecholamine excretion. Repeated immobilization stress resulted in stable arterial hypertension persisting for 6 months after stress exposure in prepubertal baboons, whereas mature males showed transitory arterial BP elevation. In both samples, repeated stress was associated with sympathoadrenal activation and elevated blood cortisol, with higher cortisol concentrations and extremely low testosterone in prepubertal animals, while mature males only showed episodic blood testosterone drops. It is suggested that rapid development of stable hypertension in prepubertal animals may be related to specific hormonal support of their response to stress.

Aging↗
PubMedDate not supplied

[Stress-protective effect of neuropeptides in monkeys].

The effects of endorphin and casomorphin on the behavior and function of steroid-producing glands were tested in 25 male baboons during free behavior and emotional stress caused by a single 2-hour immobilization. The stress-protective effect of peptide preparations was rated by the indices of the individual and social behavior of the monkeys, as well as by the level of corticosteroid and gonad systems. Exogenous opioids on the behavioral and neurohormonal manifestations of the stress-reaction in the baboons were found, which suggests that the use of regulatory peptides is promising as protective agents of emotional stress.

Animals↗
PubMedDate not supplied

[The effect of psychotropic preparations on the behavioral and hormonal manifestations of emotional stress in monkeys].

Ethological and radioimmunological techniques were used to examine the effects of psychotropic agents on the behaviour of the male Papio hamadryas and the hormonal activity of the steroid-producing glands at physiological rest and during emotional stress. Prior (15 minutes before immobilization) intramuscular administration of haloperidol, 0.1 mg/kg, amitriptyline, 2.0 mg/kg or diazepam, 0.76 mg/kg, was demonstrated to produce no stress protective effect, but to result in predominant effects of these drugs in the poststress period, or even in enhanced stress-induced behavioral and hormonal changes.

Acute Disease↗