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Biomedical subjects

S K Chutani

Publications and source records attributed to S K Chutani.

6 recordsLinked to original sources
PubMed1989

Captopril in the treatment of moderate to severe hypertension.

The converting enzyme inhibitor, captopril, in dose of 75-100 mg/day with or without diuretic was given to 40 patients (18 males, 22 females), mean age 47.5 years with moderate to severe essential hypertension. Sustained control of blood pressure was achieved in all except three patients on follow up of 12 weeks. Adverse side effects included temporary taste disturbance, rash, tachycardia, leucopaenia, nausea and transient albuminuria. No effect on electrolyte mileu was observed. First dose hypotensive or triphasic response was not noted in any patient. Our results suggest that captopril in moderate doses is very safe, acceptable and effective drug with minimal side effects for treatment of moderate to severe essential hypertension on out patient basis.

Adult↗
PubMedDate not supplied

The effect of fried versus raw garlic on fibrinolytic activity in man.

The effect of fried and raw garlic on blood fibrinolytic activity has been compared in 20 patients with ischaemic heart disease. Three blood samples were collected on the first day of the study and similarly on the 2nd and 7th days after garlic administration, either in raw or fried form. Fibrinolytic activity increased by 72% and 63% within 6 h of administration of raw or fried garlic, respectively. The elevated levels were maintained up to 12 h. In the second part of the study, raw or fried garlic was administered for 4 weeks to patients with ischaemic heart disease and fibrinolytic activity was measured at weekly intervals. It showed a sustained increase, rising to 84.8% at the end of 28th day when raw garlic was administered. Similarly, with fried garlic the rise was 72%. The study shows that: (i) both raw and fried garlic significantly enhance fibrinolytic activity (FA); (ii) garlic enhances FA within hours of administration; (iii) FA continues to rise with continued administration of garlic; (iv) frying removes the strong acrid smell of garlic, but preserves its useful effect on FA.

Coronary Disease↗
PubMedDate not supplied

Determinants of left ventricular function in isolated rheumatic mitral stenosis.

Left ventricular end-diastolic volume (preload), peak systolic wall stress (afterload), instant Emax (contractility index = peak systolic left ventricular pressure/end-systolic volume), left ventricular mass, left ventricular ejection fraction (LVEF) alone and normalised for mass index, were studied in 30 patients with isolated rheumatic mitral stenosis (group 1) and compared with 24 normal individuals (group II) who served as control. Preload was not different in the two groups (p = NS), afterload was increased in group I (p = 0.01), while LVEF, Emax, left ventricular mass and mass normalised LVEF were reduced in mitral stenosis as compared to normal control (p less than 0.01- less than 0.001). Comparison of patients with reduced ejection performance (LVEF less than 50%, n = 9, group IA) with those having normal LVEF (n = 21 group IB) revealed increased left ventricular end-diastolic volume and reduced left ventricular mass, mass normalised ejection fraction and Emax (in IA p less than 0.05). Peak systolic wall stress was comparable in these two subgroups. This study shows that the major determinant of left ventricular dysfunction in isolated rheumatic mitral stenosis is impaired contractility and not the loading factors.

Adolescent↗
PubMedDate not supplied

Dominant right ventricular dilated cardiomyopathy: clinical, echocardiographic and haemodynamic profile.

Ten patients of dominant right ventricular dilated cardiomyopathy (RVDCM) seen over a period of three years in this institution are described. There were six males and four females in the age range of 6.50 years. Presenting features were right ventricular failure (7), paroxysmal supraventricular tachycardia (2), and one patient was detected on routine chest skiagram. All patients had characteristic electrocardiographic and radiologic features. 2D-echocardiographic examination revealed enormous dilatation of right atrium, ventricular cavity and outflow tract, interatrium and ventricular septum concave to the right, pre-systolic pulmonary valve opening, small left atrium and ventricle. Pulsed doppler echocardiogram revealed varying degree of tricuspid incompetence in all. Four patients underwent haemodynamic and cineangiographic studies showing left ventricular involvement in one. The patients have been followed up on digitalis, diuretics and quinidine with variable response to treatment. One patient died of uraemia, and one female patient recovered completely following delivery. Dominant RVDCM is a distinct clinical entity with typical features and with typical features and ill-defined natural history.

Adult↗