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S K Ganguly

Publications and source records attributed to S K Ganguly.

At least 19 recordsLinked to original sources
PubMed2003

Familial aggregation of autoimmune thyroiditis in first-degree relatives of patients with juvenile autoimmune thyroid disease.

Several studies have shown aggregation of autoimmune thyroiditis in families by estimation of thyroid antibodies. However, the prevalence by concurrent estimation with fine-needle aspiration cytology (FNAC) and thyroid antibodies has not been previously reported. We therefore studied 222 first-degree relatives (group 1) of 71 index cases diagnosed as lymphocytic thyroiditis on FNAC and 81 family members (group 2) of 23 goitrous children diagnosed as colloid goiter on FNAC for comparison. Successful FNAC conducted in 122 group 1 subjects revealed lymphocytic thyroiditis in 51 (42%), whereas lymphocytic thyroiditis was diagnosed in only 5 goitrous subjects (13%) in group 2. Among group 1 subjects with FNAC-proven lymphocytic thyroiditis, antithyroid peroxidase (TPO) antibodies were found in 35 (67%), while in anti-TPO antibody positive goitrous relatives of group 1, lymphocytic thyroiditis was found in 36 (78%). Eight new cases of overt hypothyroidism and 45 new cases of subclinical hypothyroidism were diagnosed among group 1 subjects. Our study suggests: (1). familial clustering of autoimmune thyroiditis; (2). if only FNAC or thyroid antibodies is used for diagnosis of autoimmune thyroiditis in children, 22%-33% of cases are likely to be missed; and (3). serum thyrotropin (TSH) should be offered to all first-degree relatives of patients with juvenile autoimmune thyroiditis.

Adolescent↗
PubMed1996

Radioprotective effects of diltiazem on cytogenetic damage and survival in gamma ray exposed mice.

Diltiazem, a calcium ion channel blocker, already in use in cardiovascular therapeutics, has been observed to protect against bone marrow damage (cytogenetic damage, cell death) and mortality in whole body irradiated mice. The micronuclei fraction in bone marrow cells of whole body irradiated (60Co gamma rays, 2.0 Gy) mice was reduced from 2.24 +/- 0.23% to about 0.74 +/- 0.33% by preirradiation administration (-20 min) of 110 mg/kg body wt. diltiazem (ip). Endogenous colony forming unit counts in spleen of mice administered 110 mg/kg body wt. (-20 min) of diltiazem before 10 Gy whole body irradiation were 6 times more than untreated irradiated controls. Pretreatment with diltiazem accelerated the recovery of radiation induced weight loss also. Diltiazem (110 mg/kg body wt, -20 min) enhanced 30 day survival to about 95% and 85% after lethal whole body absorbed dose of 9 and 10 Gy respectively and also mitigated radiation induced life- span shortening. Post-irradiation (10 Gy) administration of diltiazem (+20 to 30 min) enhanced survival from about 2 to 15% only but was highly significant (P < 0.001). Possible modes of radioprotective action of diltiazem have been discussed.

Animals↗
PubMed1992

Demographic survey of opinions towards smoking: a pilot study.

A survey was conducted by means of a questionnaire, on 865 smokers to analyse their opinions towards some general aspects of smoking. The subjects were mostly males (97.11%) and belonged to the age group of 21 to 50 years (80%). Heavy smoking is injurious to health is the opinion of most of the smokers (90.41%) particularly when maintained with other addictions (80%); tobacco is harmful not only when smoked but also when used in other forms (63%) and moderate smoking may not be much harmful (43%). However, smoking is not necessary to make or maintain relations with others (70%). Statutory warning has no marked effect on the habit (69.83%), the role of legal restrictions is dubious but advertisements encourage the habit definitely (62.54%). Three out of 4 persons know the problems of smoking and almost the same proportion of the people think that smoking can be stopped or at least checked. But there is difference of opinion about the person to be consulted, if any such problems arises from the habit of smoking. Family physicians may play an important role in controlling the habit.

Adolescent↗
PubMed1992

The natural history of smoking.

This study is a small collection of the natural history of smoking of 865 persons - all smokers and majority (97.11%) of them were males, more than 80% were between 21-50 years, most (90%) were Hindus and 75% were service holders. It revealed that most of the subjects started smoking between 10 and 25 years of age, frequently being requested by their friends but felt nothing mentionable at their first experience. Most of them (64%) were smoking for more than 10 years, 48.56% were smoking more than 10 cigarettes in a day, filter-tipped more often (by 64% subjects) and without any history of break by 56% subjects. Majority (80%) used to inhale the smoke and 40% had no specific time of choice. Most of the subjects (80%) like to smoke in deep thoughts, 66% during excitement, 60% when depressed, 82% when relaxed and 62.5% when alone. But most of them (64%) did not smoke when busy. Majority (70.87%) felt relaxed when smoking. Most of the people (45%) stood reasonable having no cigarette in their stock. Majority (84%) used to smoke even when not offered. Tobacco was consumed largely as smoke by 75% subjects; 78% subjects smoked only cigarettes and about half of the smokers smoked even when they did not enjoy it.

Adult↗
PubMed1992

Renal involvement in kala-azar.

Fifty one patients in a series of 1000 parasitologically confirmed patients of kala-azar showing proteinuria were studied from the point of view of renal involvement. Forty two out of these patients showed blood urea above 40 mg/dl and 12 had decreased glomerular filtration rate as well. Serum creatinine level was normal in all patients including those with blood urea of more than 100 mg/dl. It is therefore suggested that although there may be glomerular involvement in some patients of kala-azar, the changes are reversible.

Animals↗
PubMed1988

Chemical radioprotection to bone marrow stem cells after whole body gamma irradiation to mice.

Protection to mice bone marrow stem cells has been noted as early as two days after whole body gamma ray exposure by prior treatment with combination of hydroxytryptophan (HT) and one of the two thiol drugs viz., aminoethylisothiuronium bromide hydrobromide (AET) (20 mg/kg body weight) and B-mercaptopropionylglycine (MPG). The levels of protection to bone marrow stem cells thus obtained have been compared to that obtained by treating with the optimum radioprotecting dose of AET (200 mg/kg body weight). The study reports the bone marrow stem cells status after two days of 3 Gy, 5 Gy and 10 Gy whole body gamma irradiation in relation to the mentioned radioprotecting treatments as studied by spleen colony forming method.

5-Hydroxytryptophan↗
PubMed1983

Protection with combinations of hydroxytryptophan and some thiol compounds against whole-body gamma irradiation.

Protection of mice (as measured by survival at 30 days) against whole-body gamma exposure by prior treatment with combinations of hydroxytryptophan (HT) and some thiol drugs, is reported here. The combination of HT and aminoethylisothiuronium bromide hydrobromide (AET) was much more effective than HT alone against the effects of 10.5 and 12.5 Gy of gamma ray exposure. A combination of HT and beta-mercaptopropionylglycine (MPG) gave marked protection against a 10.5 Gy exposure but not against 12.5 Gy. The combination of HT with cysteine or cysteamine also provided reasonable protection against 10.5 Gy. The combination of HT and cystamine rendered a low level of protection against 10.5 Gy, but again it was better than HT alone. The thiol drugs by themselves in the doses used in combination were ineffective in rendering protection after whole body gamma ray exposure.

Animals↗
PubMed1983

Role of some radioprotectors on 59Fe uptake in bone marrow after whole-body gamma irradiation to mice.

59Fe uptake in the femur has been studied at four time intervals up to 10 days in mice receiving pretreatment with hydroxytryptophan (HT), AET, MPG and combination of HT and AET or MPG and exposed to 6 Gy whole-body gamma irradiation. MPG or 20 mg/kg dose of AET pretreatment has failed to improve upon the 59Fe uptake depression induced by the gamma irradiation to mice at any of the time intervals. AET (200 mg/kg), HT + AET (20 mg/kg) and HT + MPG treatments though have failed to prevent the initial 59Fe uptake depression induced by the irradiation, have helped a speedy recovery in the iron uptake so that normal level of uptake is obtained on the 7th day. Pretreatment with the HT dose also helps in a speedy recovery as judged on the 7th day and a normal 59Fe uptake is reached in these animals by the 10th day.

5-Hydroxytryptophan↗