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Biomedical subjects

S K Kothari

Publications and source records attributed to S K Kothari.

11 recordsLinked to original sources
PubMed2004

Essential oil yield and quality of methyl eugenol rich Ocimum tenuiflorum L.f. (syn. O. sanctum L.) grown in south India as influenced by method of harvest.

A field experiment carried out during 2001--2002 under semi-arid conditions of Hyderabad, India investigated the effect of three different methods of harvesting at full bloom stage, on essential oil yield and quality of methyl eugenol rich sacred/holy basil (Ocimum tenuiflorum L.f.; Lamiaceae). The harvest methods were: harvesting of primary branches, secondary branches and shoot biomass cut at 30 cm above ground level. Four harvests at 102, 192, 287 and 360 days after transplanting of the crop were taken in 1 year in each method of harvest. Harvesting of secondary branches led to maximum plant height and number of secondary branches per plant compared to harvesting of primary branches or shoot biomass cut at 30 cm above ground during second, third and fourth harvests. On the contrary, secondary branch harvest gave least biomass yield in all the four harvests. But due to higher essential oil content, secondary branch harvest gave 25.2 and 15.4% higher total (sum total of all four harvests) essential oil yield (kg/ha per year) over primary branches and shoot biomass cut at 30 cm above ground methods of harvesting, respectively. A similar treatment difference was observed in respect of oil composition studied in the first harvest. Harvesting shoot biomass at 30 cm above ground produced oil containing highest amount of methyl eugenol. The content of methyl eugenol decreased in the order of shoot biomass cut at 30 cm above ground > primary branch > secondary branch treatments. A reverse trend was observed, however, in respect of (E)-cinnamyl acetate, eugenol and beta-elemene constituents of the oil. Little variability was, however, observed among the treatments in respect of 24 other constituents of the oils.

Biomass↗
PubMed2001

Agenesis of the skull bones.

Agenesis of the cranial bones, a rare condition usually incompatible with life, was seen in a neonate. Embryogenesis and management of the condition are discussed. The defect heals with conservative treatment.

Anti-Bacterial Agents↗
PubMed2001

Two cases of pseudoduplication of the external genitalia.

In two newborn boys an accessory rudimentary phallus and scrotal sacs were present on the surface of a midline perineal swelling. Both boys had an associated high anorectal anomaly (ARA), a small phallus, and a bifid scrotum with absence of the scrotal raphé. One also had penile torsion with hypospadias and an accessory anal dimple. During definitive surgery for the ARA in one patient, excision of the perineal soft-tissue mass and overlying duplicated penoscrotal tissue was performed. The embryogenesis of this condition is discussed.

Abnormalities, Multiple↗
PubMed2001

Female pseudohermaphroditism associated with cloacal anomalies: faulty differentiation in the caudal developmental field.

A 1(1/2)-year-old girl with a urogenital sinus defect associated with an enlarged phalluslike clitoris is described. The child had an anteriorly located anus, a single kidney with grade III vesicoureteric reflux, a 3.5-cm-long common urethrovaginal channel, a large vesical calculus, and a hamartoma in the pubic region. After a preliminary colostomy, definitive surgery consisted of urethral reconstruction, vaginal reconstruction using a colonic graft, and posterior relocation of the anus. The discussion centers on a review of the previously reported cases of female pseudohermaphroditism associated with cloacal or urogenital sinus defects (FPHCD). The likely embryogenesis of this condition is discussed, and the similarity of the features with those seen in some patients with complete penoscrotal transposition (CPST) is highlighted.

Anal Canal↗
PubMed2000

Esophageal atresia and tracheoesophageal fistula: a review of 25 years' experience.

During a 25-year period (1972-1996), 585 patients with esophageal atresia with or without tracheoesophageal fistula were treated at the Department of Pediatric Surgery, SMS Medical College, Jaipur, India. Increasing awareness of the anomaly has led to early detection and referral with fewer pulmonary complications. For purposes of analysis the period has been divided into five phases, with a steady decline in overall mortality observed from 95.4% in phase 1 to 41% in phase V. Although postoperative complications have also shown a declining trend, delay in diagnosis, prematurity, low birth weight, delayed arrival at the surgical centers, sepsis, pulmonary complications including pneumonitis, and inadequate nursing care all continue to contribute substantially to lower the survival in developing countries such as ours.

Abnormalities, Multiple↗
PubMed2000

Congenital urethral fistula.

A case of congenital urethral fistula with an intact glanular urethra without chordee is reported with a discussion of the possible etiology and one-stage repair.

Child, Preschool↗
PubMed1999

Perineal-mound defects.

Perineal-mound (PMD) and genital-fold defects cause anorectal malformations (ARM) in both sexes. They are common in females and usually present as a low anomaly (except rectovestibular fistula). They are rare in males and present as an intermediate anomaly. A common embryological explanation for these defects with varied presentation in males and females is discussed. These anomalies should be grouped separately in the classification of ARM. We present five male patients with PMD, three of whom had imperforate anus with rectobulbar fistula and perineal hypospadias and two who had imperforate anus with rectoperineal fistula.

Anus, Imperforate↗
PubMed1999

Megalourethra with posterior urethral valves.

A case of scaphoid megalourethra associated with the posterior urethral valves was seen in a 4-year-old male. The embryology of the anomaly and its management are discussed with a review of the literature.

Child, Preschool↗
PubMed1989

Repression of human cytomegalovirus gene expression associated with a novel immediate early regulatory region binding factor.

A major determinant controlling reactivation of persistent viruses is likely to be the level of cellular factors which regulate virus transcription. Human cytomegalovirus (the largest human herpesvirus) does not replicate in human teratocarcinoma (T2) cells due to a block in transcription of immediate early (IE) gene expression, but these cells become permissive upon retinoic acid induced differentiation. We have analysed changes in DNA binding factors to the major IE promoter/regulatory region of HCMV that occur during differentiation of T2 cells to a permissive phenotype. We show that undifferentiated T2 cells contain a specific nuclear factor that binds to a far upstream region of the major IE regulatory region. Differentiation of T2 cells is associated with a major decrease in this factor and deletion of its specific binding site from IE expression vectors also results in increased levels of expression in undifferentiated cells. Consequently, this novel factor present in undifferentiated cells is a candidate for a differentiation specific negative regulator of HCMV IE gene expression which binds to an element upstream of the major IE enhancer.

Base Sequence↗