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Biomedical subjects

S K Rosemberg

Publications and source records attributed to S K Rosemberg.

At least 19 recordsLinked to original sources
PubMed1991

Sexually transmitted papilloma viral infection in the male. VII. Is cancer of penis sexually transmitted?

Four cases are reported of squamous cell carcinoma of the genital tract in males. The close association of HPV 16/18 with in situ squamous carcinoma affecting the penis is demonstrated. The first documented case of a primary penile squamous cell carcinoma with metastatic deposits yielding positive HPV 16/18 isolates as shown by in situ DNA hybridization again demonstrates a close association of this virus to malignancy in humans. The clinical implications of these findings strongly suggest that squamous cell carcinoma of the penis is a sexually transmitted disease. A thorough examination of both sexual partners is necessary when Bowenoid papulosis or penile carcinoma is present, since the female partner is at high risk for cervical neoplasia.

Adult↗
PubMed1991

Sexually transmitted papillomaviral infection in men. An update.

Clinical experience gained from the assessment of 345 men over the past 10 years is analyzed to determine the clinical features of sexually transmitted papillomaviral infection in men, the patterns of anatomic distribution, the results of follow-up, the types of HPV associated with specific disease patterns, and the outcome of different methods of therapy.

Condylomata Acuminata↗
PubMed1990

Sexually transmitted papillomaviral infection in the male: VI. Simultaneous urethral cytology-ViraPap testing of male consorts of women with genital human papillomaviral infection.

A series of 122 males at high risk for development of human papillomavirus (HPV) infection were prospectively studied with simultaneous urethral brushing cytology and ViraPap, to establish their relative sensitivity and specificity in relation to the diagnosis of HPV infection in the urethral canal. The prevalence of disease in this high-risk population was 10 percent. The sensitivity of DNA hybridization was determined to be 67 percent, with a 100 percent specificity, as compared with a 25 percent sensitivity of cytologic analysis. Physical examination alone had a 75 percent sensitivity. Physical examination with ViraPap urethral analysis identified all patients with urethral HPV-associated disease. These results indicate that clinical examination alone misses one quarter of the HPV-involved patients.

Colposcopy↗
PubMed1989

Sexually transmitted papillomaviral infections: IV. The white scrotum.

Retrospective review of 353 male patients, partners of women with known HPV infection, revealed a 22 percent (77) incidence of subclinical scrotal involvement histologically characterized by koilocytosis, and clinically diagnosed only by the routine application of 3% acetic acid. Previous viral typing of 20 of these subclinical lesions revealed HPV DNA in 8 cases. Of these 4 contained high-risk HPVs, suggesting that the "white scrotum" is an important reservoir for the transmission of HPV to the female genitourinary tract.

Acetates↗
PubMed1989

Sexually transmitted papillomaviral infections: V. Prophylactic use of topical 5-fluorouracil in refractory infection in the male.

The topical administration of 5% fluorouracil (Efudex) was used on 60 males afflicted with recurrent papillomaviral infection, all partners of women with proved HPV disease. The overall response to the medication was 84 percent (total plus partial responses) for those patients afflicted with mixed disease of the shaft, compared with the subclinical and exophytic varieties with 70 and 67 percent response, respectively. Because HPV infections tend to be a field phenomenon involving the entire lower genital tract, this simple form of treatment, that is locally applied with few side effects, appears to be ideal for the management, prophylaxis, and treatment of recurrent disease.

Administration, Topical↗
PubMed1988

Laser vasovasostomy. A comparative retrospective study, using bioquantum microsurgical carbon dioxide laser.

Microsurgical carbon dioxide (CO2) vasovasostomy was successfully achieved by fusion coagulation of protein with power densities of 40 W/cm2. When 20 and 32 W/cm2 were used, the histologic picture was found to be a uniform leakage of sperm with secondary granuloma formation, suggesting that at this power density, unsuccessful attempts at welding the vas deferens will result.

Animals↗
PubMed1988

Further clinical experience with CO2 laser in microsurgical vasovasostomy.

Herein are reported the results obtained in 14 patients with the performance of vasovasostomy by carbon dioxide (CO2) laser. Fusion coagulation of the vas wall was successfully accomplished as demonstrated by postoperative sperm counts of over 20 million/mL in 86 per cent of the patients, and a pregnancy rate of 43 per cent in the group of patients operated on within less than ten years of original vasectomy. In contrast, those patients undergoing vasovasostomy ten years after original vasectomy had sperm counts of over 20 million/mL in 43 per cent of the cases, with a zero pregnancy rate. A significant reduction in total operative time was achieved as compared to the conventional microsurgical suture technique, corroborating the ability of the CO2 laser to simplify this technique while producing a sperm-tight anastomosis. One of the drawbacks of this operation is that it is not suited for the performance of a vasoepididymostomy which could be required in those cases in which sperm is absent from the vas fluid at the time of vasovasostomy.

Adult↗
PubMed1988

Sexually transmitted papillomaviral infection in the male: II. The urethral reservoir.

Urethral cytobrushing for hybridization studies was obtained from the anterior urethra of 75 male consorts of known HPV-infected female partners. Our findings revealed a 24 per cent (19 patients) incidence of positive hybridization, identifying HPV-16 or HPV-18 in six instances associated with mixed papillomaviral infection of the shaft and the presence of HPV-6 and HPV-11 in 7 cases clinically related to exophytic disease of the shaft. Although no histologic evidence of virus-tissue interaction could be demonstrated, careful follow-up is recommended to detect early recurrent disease with its potential for partner reinfection.

Adolescent↗
PubMed1988

Sexually transmitted papillomaviral infections: III. Management of male partner.

The treatment of 199 males afflicted with sexually transmitted papillomaviral infections has shown that to be successful, periodic and prolonged follow-up is necessary to detect recurrent disease. Results of superficial epidermectomy using a battery-powered eye cautery in 49 cases with a few clusters confined to the shaft showed a 40 per cent recurrence rate. The carbon dioxide (CO2) laser was successful in eradicating 75 to 82 per cent of the cases presenting with extensive subclinical and exophytic disease. Meatal as well as perianal infection responded adequately to a single vaporization, using power densities ranging from 200-500 W/cm2 in 98 per cent and 78 per cent of the cases, respectively. Scrotal disease was best managed by the topical application of 5-fluorourocil with a cure rate of 82 per cent and in 36 per cent (17 cases) spontaneous disappearance with a faint acetowhite stain suggesting an abortive type of infection. It is apparent that to be effective the successful treatment of papillomaviral infections in the male must rely on periodic and prolonged follow-up to detect recurrent disease, and must include different treatment modalities to be used in accordance with clinical presentation and anatomic location of the disease.

Adolescent↗
PubMed1987

Sexually transmitted papillomaviral infections in the male: I. Anatomic distribution and clinical features.

The epidemic of sexually transmitted papillomaviral infection and the suspected role of this virus in the etiology of squamous cancer within the lower genital tract make the clinical assessment of male consorts an essential component in disease control. Of 223 infected sites in 154 males, only 56 per cent of areas showed classic exophytic condylomata. The remaining 44 per cent were detected only after application of 3% acetic acid. Despite the dramatic macroscopic differences between the subclinical and condylomatous variance of human papillomaviral (HPV) infection, both forms showed infectious virus particles. Hence, soaking with 3% acetic acid and examination using a hand lens should become a routine part of the clinical examination for papillomaviral infection in the male genitalia.

Adolescent↗
PubMed1987

Some guidelines in use of lasers in renal surgery.

Some guidelines for the use of lasers in renal surgery are presented. The carbon dioxide laser was successfully used in 9 patients with diverse renal pathology (staghorn calculus, 4 patients; renal tumor, 3 patients; congenital arteriovenous (A-V) fistula, 1 patient; segmental chronic atrophic pyelonephritis, 1 patient) as an excisional tool, allowing us to reduce intraoperative blood loss, decrease operating time, and preserve the functional integrity on the remaining renal segment. This modality appears to be a safe addition to the urologic armamentarium, when used as an excisional tool in renal surgery.

Adult↗
PubMed1987

Clinical use of carbon dioxide (CO2) laser in microsurgical vasovasostomy.

Herein are reported the first 4 clinical cases of carbon dioxide (CO2) laser microsurgical vasovasostomy. Fusion-coagulation of the vas wall was successfully accomplished, as demonstrated by adequate postoperative sperm counts and a 50 per cent pregnancy rate. A significant reduction in the total operative time was achieved as compared with the conventional microsurgical suture technique, corroborating the ability of the CO2 laser to simplify this technique while producing a sperm-tight anastomosis.

Adult↗
PubMed1987

Sexually transmitted papillomaviral infection in men.

Clinical experience gained from the assessment of 291 men over the last 8 years is analyzed to determine the clinical features of sexually transmitted papillomaviral infection in males, the patterns of anatomic distribution, the results of follow-up, the types of HPV associated with specific disease patterns, and the outcome of different methods of therapy.

Follow-Up Studies↗
PubMed1986

Lasers and squamous cell carcinoma of external genitalia.

Herein is presented our experience with 4 cases of squamous cell carcinoma of the external genitalia, managed by laser vaporization-coagulation. Our results indicate that laser therapy offers the potential for cure of early cases of genital carcinoma where traditional treatment has been refused or medically not possible. No associated morbidity was found. Exceptional cosmetic results were obtained, and this appears to be an added advantage.

Adult↗
PubMed1985

Carbon dioxide laser treatment of external genital lesions.

Our entire clinical experience with the use of carbon dioxide (CO2) laser in the treatment of 67 patients with diverse external genital lesions is presented. Successful eradication was accomplished in 61 patients with wide distribution of condylomatous lesions, with 88 per cent responding to a single laser treatment. Excellent cosmetic results, as well as complete disappearance of balanitis xerotica obliterans and erythroplasia of Queyrat, were observed in 5 additional patients. Laser therapy, although not an established treatment option, appears to be a safe alternative and should be considered in those patients with recurrent genital condylomata, balanitis xerotica obliterans, as well as erythroplasia of Queyrat, not responding to well-known treatment modalities.

Adolescent↗
PubMed1985

Subclinical papilloma viral infection of male genitalia.

One hundred male patients with a history of genital condylomata were evaluated by the use of 3% acetic acid staining of their external genitalia. In 36 per cent positive aceto-white areas were discovered on the shaft of the penis (flat condylomata), and a 35 per cent meatal-urethral involvement, suggesting that flat and exophytic condylomata of the shaft and urethra are the most logical reservoir for transmitting the HPV infection to the female genitourinary tract.

Acetates↗
PubMed1985

Clinical experience with carbon dioxide laser in renal surgery.

Our clinical experience in renal surgery utilizing the CO2 laser is presented. The inherent characteristics of precision and hemostasis of this modality were found to be useful in the performance of three anatrophic nephrolithotomies and three partial nephrectomies. Operative time ranged between 110 and 120 minutes, with an average estimated blood loss of 160 cc per case. Surgery on the kidney parenchyma with CO2 laser appears to be a safe and effective modality, reducing blood loss, shortening operative time, and preserving functional integrity on remaining renal tissue.

Adult↗