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Biomedical subjects

S K Sadhu

Publications and source records attributed to S K Sadhu.

4 recordsLinked to original sources
PubMed2001

Analgesic, diuretic, and anti-inflammatory principle from Scoparia dulcis.

Scoparinol, a diterpene, isolated from Scoparia dulcis showed significant analgesic (p < 0.001) and anti-inflammatory activity (p < 0.01) in animals. A sedative action of scoparinol was demonstrated by a marked potentiation of pentobarbital-induced sedation with a significant effect on both onset and duration of sleep (p < 0.05). Measurement of urine volume after administration of scoparinol indicated its significant diuretic action.

Algorithms↗
PubMed1997

Preliminary studies on the antiinflammatory, analgesic and diuretic activity of stagninol, a sesquiterpene isolated from Persicaria stagnina.

Stagninol, a sesquiterpene, isolated from Persicaria stagnina Linn showed significant antiinflammatory and analgesic activity (P < 0.001) in animals. A sedative action of stagninol was revealed by a marked potentiation of pentobarbital induced sedation with significant effect on both onset (P < 0.001) and duration (P < 0.01) of sleep. Measurement of urine volume after administration of stagninol indicated its significant diuretic action. Biochemical investigations revealed that both crude extract and stagninol showed dose dependent reduction of blood uric acid and blood urea nitrogen (BUN). There was an increase in serum glutamic pyruvic transaminase (SGPT) and serum alkaline phosphatase (SAP) level with the crude extract but stagninol showed no significant changes of serum glutamic oxaloacetic transaminase (SGOT), SGPT and SAP level.

Analgesics, Non-Narcotic↗
PubMedDate not supplied

Subpolar tuberculoid leprosy.

Existence of subpolar tuberculoid leprosy was postulated by a few leprologists to explain clinical variations near the tuberculoid pole but failed to precisely identify the same. An attempt has been made to describe the clinical and histological features of subpolar tuberculoid leprosy. 76 cases of the TT-BT range according to Ridley-Jopling classification were examined by detailed clinical, histological and immunological methods. Definite clinical and histological discrepancies from either BT or TTp were seen in 30 (39.4%) cases, confirming the existence of subpolar tuberculoid leprosy (TTs) and thus clarifying the immunological spectrum of leprosy.

Humans↗