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Biomedical subjects

S K SenGupta

Publications and source records attributed to S K SenGupta.

At least 19 recordsLinked to original sources
PubMed2001

Organochlorines and breast cancer risk by receptor status, tumor size, and grade (Canada).

OBJECTIVE: We evaluated the association between organochlorines and breast cancer subtype defined by the tumor characteristics: estrogen receptor status, progesterone receptor status, tumor size, and grade. METHODS: A case-control study was conducted from 1995 to 1997 in Kingston and Toronto, Canada. Breast adipose tissue, taken from 217 cases and 213 biopsy controls frequency-matched on age, was analysed for 14 polychlorinated biphenyl (PCB) congeners and 10 pesticides. RESULTS: Adjusting for age, geometric means of several organochlorines differed by estrogen receptor status and tumor grade (p < 0.05). Odds ratios (ORs) for each organochlorine relative to the common control group for breast cancers of differing subtype were compared using polytomous logistic regression. Although the ORs did not differ significantly by subtype, the ORs of PCBs and p, p'-1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) were higher with risk of estrogen receptor-negative breast cancer than estrogen receptor-positive breast cancer. One of the most extreme differences was with DDE, where the OR for the association with risk of estrogen receptor-negative breast cancer was 2.4 (95% confidence interval (CI) 1.0-5.4) in the uppermost tertile relative to the lowest, whereas the corresponding OR for risk of estrogen receptor-positive breast cancer was 1.1 (95% CI 0.6-1.9). PCBs also tended to be more strongly positively associated with risk of larger and higher-grade tumors. CONCLUSIONS: The association between organochlorines and breast cancer risk did not significantly differ by subtype, but many PCBs were more strongly associated with tumors of poor prognosis.

Adipose Tissue↗
PubMed2000

Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk.

Numerous studies have examined the relationship between organochlorines and breast cancer, but the results are not consistent. In most studies, organochlorines were measured in serum, but levels in breast adipose tissue are higher and represent cumulative internal exposure at the target site for breast cancer. Therefore, a hospital-based case-control study was conducted in Ontario, Canada to evaluate the association between breast cancer risk and breast adipose tissue concentrations of several organochlorines. Women scheduled for excision biopsy of the breast were enrolled and completed a questionnaire. The biopsy tissue of 217 cases and 213 benign controls frequency matched by study site and age in 5-year groups was analyzed for 14 polychlorinated biphenyl (PCB) congeners, total PCBs, and 10 other organochlorines, including p,p'-1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene. Multiple logistic regression was used to assess the magnitude of risk. While adjusting for age, menopausal status, and other factors, odds ratios (ORs) were above 1.0 for almost all organochlorines except five pesticide residues. The ORs were above two in the highest concentration categories of PCB congeners 105 and 118, and the ORs for these PCBs increased linearly across categories (Ps for trend < or =0.01). Differences by menopausal status are noted especially for PCBs 105 and 118, with risks higher among premenopausal women, and for PCBs 170 and 180, with risks higher among postmenopausal women. Clear associations with breast cancer risk were demonstrated in this study for some PCBs measured in breast adipose tissue.

Adipose Tissue↗
PubMed1998

Langerhan cell granulomatosis with unusual FNAC findings.

An interesting case of a multifocal Langerhans cell granulomatosis in an 18-mo-old female child is described. The diagnosis was confirmed by fine-needle aspiration cytology. The unusual findings at the initial stage of the disease and its possible etiopathogenesis are discussed.

Biopsy, Needle↗
PubMed1998

A study of the correlation of prostatic pathology and serum prostate-specific antigen (PSA) levels: a perspective from Papua New Guinea.

A review of serum prostate-specific antigen (PSA) values from January 1994 to May 1997 and their correlation with the histopathology of prostate specimens was carried out in the Department of Pathology, Port Moresby General Hospital. The study has shown that this biochemical investigation has not been properly used for the maximum benefit of the patient population. Remedial measures are suggested to improve the sensitivity and specificity of PSA in a setting with limited resources.

Aged↗
PubMed1996

Malignant lymphomas in Papua New Guinea: an immunohistological study of 125 cases.

A total of 179 cases of lymphoma, both nodal and extranodal, recorded in the Papua New Guinea Tumor Registry were reviewed and classified by the updated Kiel classification. Fifteen (8.4%) were Hodgkin's disease, 39 (21.8%) probable Burkitt's lymphoma (poorly preserved), 46 (25.7%) Burkitt's lymphoma, 33 (18.4%) Burkitt's-like lymphoma, 36 (20.1%) other B-cell subtypes and 10 (5.6%) T-cell lymphoma. No case of follicular B-cell lymphoma was encountered.

Humans↗
PubMed1996

Sclerosing stromal tumour of the ovary.

Two cases of sclerosing stromal tumour of the ovary in young Melanesian females are described and the differential diagnosis is discussed. Sclerosing stromal tumour of the ovary is a rare benign tumour of ovarian stromal origin which is associated with endocrine activity in a few cases. One of the patients presented with signs of precocious puberty and the tumour in this patient was considered as a functioning lesion.

Adult↗
PubMed1995

Liver disease in Papua New Guinea 1981 to 1988, twenty years after the first surveys were done.

Twenty years after the first surveys of liver disease were done cirrhosis and hepatocellular carcinoma were still found to be the most important liver diseases in Papua New Guinea. Hepatitis B virus appears to be the main cause of both these conditions. Data from a number of different sources suggest a prevalence of hepatitis B positivity of about 17%. The most significant new finding was grade 3 iron deposition in 8 patients. This raises the question as to whether iron storage disease may now contribute to the spectrum of liver disease in Papua New Guinea. Many biopsies in the 1960s and 1980s were interpreted as nonspecific hepatitis; in the light of recent observations, at least some of these may have been due to hepatitis C infection.

Adolescent↗
PubMed1993

Binding pattern of eight different lectins in healthy subjects and patients with dysplastic and malignant lesions of the oral cavity.

The present investigation was undertaken to assess the binding characteristics of eight different lectins to normal oral mucosa (11 cases), leukoplakia with varying degrees of dysplasia (five cases), and oral mucosal squamous cell carcinoma (12 cases) by the use of biotinylated lectins and avidin biotin peroxidase complexes. The lectins employed were soybean (SBA), peanut (PNA), Dolichos biflorus (DBA), concanavalin A (Con A), wheat germ (WGA), Ulex europaeus (UEA), Ricinus communis (RCA), and Lotus tetragonolobus (LTA). It was observed that SBA, DBA, WGA, UEA, RCA, and LTA showed very strong to strong binding in healthy oral mucosa but no or very weak binding in squamous cell carcinoma. On the contrary, PNA showed weak binding to normal mucosal epithelial cells but showed strong binding to malignant cells. The dysplastic mucosa had an intermediate binding pattern. The lectin Con A was not bound at all or seen in very low concentration in the malignant cells and dysplastic epithelium, but it showed weak binding in the normal mucosa. Hence, we conclude that lectins may be utilized as probes to determine the dysplastic and malignant status of the oral mucosal epithelium.

Adult↗
PubMed1992

Cervical paravertebral leiomyosarcoma mimicking a nerve sheath tumor.

A rare case of leiomyosarcoma attached to the C6 nerve root with extension through the intervertebral foramen into the spinal canal is described. Clinically and at the time of frozen section, this was considered to be a nerve sheath tumor. A definitive histologic diagnosis was made on the basis of the ultrastructural features of the tumor. Complete remission was achieved following extensive surgical removal and postoperative radiotherapy. The possible origin of this neoplasm is discussed.

Adult↗
PubMed1992

Gentamicin resistance in fatal Klebsiella septicaemia.

The occurrence of antibiotic resistance in nosocomial infections is a common problem. This case details a fatality associated with Klebsiella infection acquired as a hospital inpatient. The transfer of gentamicin resistance between gram-negative bacteria could present a considerable problem in Papua New Guinean hospitals.

Adult↗
PubMed1992

The brain in cerebral malaria: a pathological study of 24 fatal cases in Papua New Guinea.

The pathological features of cerebral malaria in 24 fatal cases are described. The cases included 18 adults aged from 16 to 45 years and 6 children aged from 1 to 15 years. All were unconscious before death. Gross pathological findings in the brain included cerebral oedema, vascular congestion and petechial haemorrhages. Little clinical and laboratory information was available on these patients. Histological examination revealed parasitized red blood cells in all, ring haemorrhages in 6, hyaline material in the wall of medium-sized blood vessels in 4, and vascular thrombosis in 4.

Adolescent↗
PubMed1992

Benign breast disease in Papua New Guinea.

In this study 302 biopsy-confirmed benign breast lesions in Papua New Guinean (Melanesian) women during a ten-year period were reviewed. Inflammatory breast disease was the most frequent type. Chronic mastitis, chronic suppurative mastitis and abscesses formed 32% of benign breast lesions and 71% of the group of mastitides. 10 cases of tuberculous mastitis were recorded. Fibrocystic disease was observed at a lower age (31.9 +/- 8.2 years) than has been reported from Black United States and West Indian populations. The high frequency of mastitis is an important finding. This is most likely to be associated with lactation. Proper hygiene during breastfeeding and the judicious use of antibiotics should reduce this high frequency. Education of women about these matters should form part of health education programs in Papua New Guinea.

Adult↗
PubMed1991

Clinicopathological features of primary gastrointestinal lymphomas: a study of 42 cases.

The clinicopathological features of 42 patients with gastrointestinal lymphoma during the period 1982-88 are described. Ten cases (23.8%) were seen in the stomach, 23 cases (54.8%) in the small intestine and 9 cases (21.4%) in the large intestine. In 4 cases multiple sites were involved. The tumours occurred most frequently in the 2nd to 4th decade. Histologically, using the working formulation for non-Hodgkin's lymphoma, all were found to be diffuse and mostly of the high grade type (45%). Seven lymphomas were seen in children. Three were of the Burkitt's type. Patients presented quite late in a large number of cases (43%). Compared with most other published series small intestinal involvement was common. There was a high incidence in males. Predominant small intestinal involvement did not result in malabsorption syndrome and primary lymphomas constituted 3.5% of all malignancies of the gastrointestinal tract.

Adolescent↗
PubMed1991

Pathogenesis of Venezuelan equine encephalitis virus infection in mice and hamsters.

The pathogenesis of Venezuelan equine encephalitis (VEE) virus infection was compared in intraperitoneally inoculated mice (n = 24, 6 to 8 weeks old) and hamsters (n = 9, 90-110 g) using histopathology and immunohistochemical localization of VEE virus antigen. Infected mice developed paralysis, and the majority died by 9 days after inoculation. In contrast, hamsters did not survive beyond 3 days after inoculation, and they did not develop any neurologic signs. VEE virus antigen, demonstrated by immunoperoxidase staining, and pathologic changes were present in extraneural organs of both mice and hamsters. There was more severe involvement in hamsters, particularly in Peyer's patches of the distal small intestine. There was a severe encephalomyelitis in mice, but pathologic changes were not well established in the brains of hamsters before death. VEE virus antigen was widespread in the central nervous system of both mice and hamsters. VEE virus was found to be highly neurotropic in hamsters and had a similar distribution in the brain as in mice, but hamsters died from their extraneural disease before major central nervous system disease developed.

Animals↗
PubMed1991

Nasal cartilaginous tumour.

A cartilaginous tumour of nasal region in a 6-year-old child is described. The problems of histological interpretation and treatment are discussed.

Cartilage Diseases↗