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Biomedical subjects

S K Seth

Publications and source records attributed to S K Seth.

17 recordsLinked to original sources
PubMed2000

Enoxaparin and bleeding complications: a review in patients with and without renal insufficiency.

STUDY OBJECTIVE: To compare the frequency of bleeding complications from enoxaparin in patients with normal renal function versus patients with renal insufficiency. DESIGN: Retrospective chart review. SETTING: University-based tertiary care center. PATIENTS: One hundred six patients who received two or more doses of enoxaparin. MEASUREMENTS AND MAIN RESULTS: Total bleeding complications occurred in 22% of patients with normal renal function and 51% with renal insufficiency (p<0.01). Major bleeds were also significantly different, 2% and 30%, respectively (p<0.001). No patients with normal renal function were given fresh-frozen plasma or packed red blood cells, whereas in those with renal insufficiency, 13% and 32%, respectively, received these products (p<0.01). CONCLUSION: Enoxaparin may have resulted in increased bleeding complications and use of blood products in patients with renal insufficiency. Prospective studies need to be conducted to define the drug's role and dosage adjustments in these patients.

Aged↗
PubMed1999

Desensitization to allopurinol in a patient with previous failed desensitization.

OBJECTIVE: To describe an allopurinol desensitization that failed on the first attempt but was successful on the second attempt, resulting in the management of crippling tophaceous gout. CASE SUMMARY: A 64-year-old white man with a history of gouty nephropathy requiring hemodialysis developed a severe cutaneous reaction from exposure to allopurinol. The first desensitization attempt was unsuccessful, and the gouty nephropathy caused chronic cellulitus and urate microcrystal deposition on the patient's hands and feet. Continuous ambulatory peritoneal dialysis and hemodialysis were used to treat the patient's severe symptoms and increase uric acid clearance. This method, however, was ineffective. Severe tissue ischemia, requiring bilateral below-the-knee amputations, prompted the second desensitization attempt four years later. The second attempt, administered differently and with more caution, was successful and did not cause further complications. DISCUSSION: Allopurinol is the only agent available to effectively reduce uric acid concentrations in those who are over-producers. Hypersensitivity-type reactions have been reported with its use, and desensitization is the only viable therapeutic option. Few cases of desensitization to allopurinol have been reported in the literature. This article describes a failure and a subsequent success in desensitization to allopurinol. CONCLUSIONS: Although desensitization to allopurinol poses potential risks, the benefits can outweigh the risks of therapy. Desensitization requires close monitoring; if failure does occur, subsequent attempts can be successful, as this case report demonstrates.

Allopurinol↗
PubMed1981

Immunological significance of lymphoreticular infiltration in gastrointestinal cancer.

The 60 patients of gastrointestinal cancer comprising this study were in the age range of 29--70 years with 39 males and 21 females. The primary sites of cancer were: gallbladder 19, colon 13, stomach 12, anorectum 8, and liver 8. The stage of tumor spread was localized in 32 and metastatic in 28 cases. Round cell infiltration scores were classified semiquantitatively from O-V. Cellular immunity as expressed by the blood lymphocyte count and DNCB reactivity was also studied. Round cell infiltration was dense in the localized group (P less than 0.0005). The mean lymphocyte counts in all the primary sites of gastrointestinal cancer were significantly higher in the localized group as compared to metastatic group. The DNCB reactivity showed anergy in six cases and poor response in the remaining 22 cases of metastatic group. There was a statistically significant correlation between lymphoreticular infiltration, peripheral blood lymphocyte count, and the DNCB reactivity. Diminished round cell infiltration, lymphopenia, and depressed DNCB response indicate an advanced stage of gastrointestinal cancer.

Adenocarcinoma↗
PubMed1981

Simultaneous bilateral central dislocation of the hip--an unusual complication of eclampsia.

Bilateral hip injuries are rare. A case of bilateral central dislocation of the hip caused by eclamptic convulsions is reported because of its rarity. Further, eclampsia as a cause of bilateral central dislocation has not been reported earlier. All the earlier 11 cases were due to therapeutic convulsions before 1960. The patient reported here was ambulatory 6 months after injury, with some restriction of rotation and abduction.

Adult↗
PubMed1980

Delayed cutaneous hypersensitivity and blood lymphocyte count in advanced Hodgkin's and non-Hodgkin's lymphomas.

Cell-mediated immune status was assessed in twenty patients of advanced and active lymphoreticular malignancies and twenty control subjects of comparable age and sex distribution by delayed cutaneous hypersensitivity responses to recall and contact antigens and peripheral blood lymphocyte counts. The results show depressed cellular immunity in both Hodgkin's and non-Hodgkin's lymphoma patients. However, the severity of immunological dysfunction as shown by anergy to skin antigens and lymphocytopaenia is remarkably less than what has been mostly reported in the literature.

Antigens↗
PubMed1980

Delayed cutaneous hypersensitivity ad peripheral blood lymphocyte counts in gastrointestinal cancer.

Cell-mediated immune responses as expressed by delayed cutaneous hypersensitivity (DCH) reactions to specific recall antigens (PPD and BCG) and non-specific contact antigen (DNCB), and peripheral blood lymphocyte counts were studied in 60 patients of gastrointestinal cancer and 20 control subjects. The pattern of these immune responses in gastrointestinal cancer was significantly different from tumour-free control subjects of comparable age and sex distribution and apparently indicates a depressed immunologic function in cancer patients. Our study suggests that DNCB skin testing and peripheral blood lymphocyte counts are relatively simple and reliable investigations for predicting the advanced stage of gastrointestinal cancer (and BBY implication prognosis).

Adult↗
PubMed1975

Sphingomyelin and other phospholipid metabolism in the rabbit atheromatous and normal aorta.

Hypercholesterolemia induces atheroma formation, and the concentration of sphingomyelin is increased compared with that in the normal aortic intima-media. The aortic intima-media sphingomyelin concentration appears to increase exponentially with time on the cholesterol diet. Moreover, the entry rate of serum sphingomyelin into the aortic wall also appears to increase exponentially with time on the cholesterol diet and with the extent of aortic exposure to hypercholesterolemia. 32P-Phosphate incorporation into sphingomyelin and other phospholipids in the perfused rabbit aorta does not increase with atheromatosis, but the rate of sphingomyelin entry increases 27-fold during approximately the same period of atheroma formation and can account for all of the increase in sphingomyelin concentration in the intima-media.

Animals↗