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S K Thatcher

Publications and source records attributed to S K Thatcher.

2 recordsLinked to original sources

Exercise stress testing in the patient with coronary artery disease. Part I.

Treadmill cardiac stress tests have a number of well known, identifiable criteria for positivity. One that is less known and thus often not appreciated, is the appearance of an inverted U wave in the left chest leads at the peak of exercise. This, even as an isolated finding, indicates a positive test. Of clinical significance is that this electrocardiographic response to a stress test is associated with an isolated lesion of the left anterior descending coronary artery.

Coronary Disease

Digitalis-quinidine interaction.

An interaction between quinidine and digoxin is known to occur with toxic concentrations of digoxin in the serum resulting when the two drugs are administered together. The effects can be very dangerous, especially in those patients with advanced and severe cardiac disease. When prescribing quinidine for patients who are taking digoxin, the dose of digoxin should be reduced by half. The patient should be followed carefully, and the electrocardiogram and serum digoxin concentration monitored in order to adjust the digoxin dose.

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