Biomedical subjects
Publications and source records attributed to S Kaifie.
The distribution of properdin factor B (Bf) phenotypes and gene frequencies was studied in four populations of Afghanistan: Hazaras, Pushtoons, Tajiks and Usbeks. Significant differences between Usbeks and the other three ethnic groups were observed. The distribution of gene frequencies in Usbeks was similar to that of European populations.
In four population groups of Afghanistan, the Pushtu, Tajik, Hazara, and Usbek, the red cell enzymes EsD, GPT, AcP, PGM1, ADA, AK, and 6PGD were studied. Significant differences in frequency occurred between the Hazara and others in 6PGD, PGM1, and AK system, and between the Pushtu and others in the ADA system.
Studies of the acetylator polymorphism in Pushtoons, Tajiks, Hazaras and Usbeks living in Afghanistan revealed a lower frequency of the allele ACS in the last two populations. The results were compared with those of other populations. The importance of this polymorphism for therapy and a possible relation to the use of alkaloids in form of spices and drugs is discussed.
Gene frequencies of the serum proteins third component of complement (C3) transferrin (Tf), haptoglobin (Hp), group specific component (Gc), serum cholinesterase (E1), alpha1-antitrypsin (Pi), beta2-glycoprotein I (Bg), and ceruloplasmin (Cp) in the Tajiks, Pushtoons, Hazaras, and Usbeks in Afghanistan were reported. Rare variants were observed in the C3, Tf, and Pi systems.
The C3 phenotype distribution was studied in 4 different populations from Afghanistan. The gene frequencies of C3S allele were: Tajiks (0,8547), Pushtoons (0.8812), Hazaras (0.9036) and Osbeks (0.8530). These values were significantly higher than in European populations studied previously. No significant differences were found between the mean serum levels of C3, C4 and C3-proactivator among 4 population groups. A higher concentration of IgG, IgA and IgM was observed in Afghanistan sera than reported for Europeans.