Biomedical subjects

S Kalath

Publications and source records attributed to S Kalath.

2 recordsLinked to original sources

PubMed1987

Increased aortic root stiffness associated with osteogenesis imperfecta.

M-mode echocardiograms obtained from 31 patients with types I and IV osteogenesis imperfecta (OI) were evaluated for increased aortic root dilatation and wall stiffness. Four patients were observed to have dilated aortic roots. The pressure-strain elastic moduli (Ep) of the majority of OI patients studied were significantly different from those of age-matched controls; the observed values of Ep were both greater and less than that of controls. At high strain in the circumferential direction, nine of 31 OI patients had aortic roots that were significantly stiffer than those of controls. Increased stiffness in the circumferential direction was associated with decreased aortic pumping efficiency. The increased stiffness observed in the circumferential direction is consistent with increased accumulation and crosslinking of collagen within the aortic wall and may reflect premature aging of OI patients.

Adult↗

PubMed1986

Non-invasive assessment of aortic mechanical properties.

Echocardiography and sphygmomanometry were used to noninvasively assess the changes in aortic mechanical properties associated with aging. Fifty normal individuals were examined and were divided into three groups: young (less than 35 years of age), middle-aged (35-55), and old (greater than 55). Experimental measurements indicated that elastic aortic stiffness in the circumferential direction increased with increased age. It was concluded that this was consistent with increased deposition of circumferentially oriented collagen within the media. Associated with increased elastic aortic stiffness in the circumferential direction was a decrease in the ability of the aorta to act as an auxiliary pump. The average work per unit length recovered from aortas of older individuals was only 44% of that recovered from the aortas of individuals in the young group. These studies suggest that increased elastic aortic stiffness results in decreased aortic pumping efficiency and may lead to a compensating increase in blood pressure.

Adult↗