PubMed Health⌕ Search

Biomedical subjects

S Kallichurum

Publications and source records attributed to S Kallichurum.

15 recordsLinked to original sources
PubMed1984

The iron status of Black subjects with amoebiasis.

Hepatic iron concentrations were measured in 60 Black patients who had died of amoebiasis. There were 18 infants and young children, 30 adult males and 12 adult females. The mean hepatic iron concentration in infants was normal (0,11% dry weight), while those in adult males and females were significantly raised (0,64% and 0,30% dry weight respectively). The figures for adults are somewhat higher than those previously found in Black subjects, suggesting that iron overload is more common in patients with amoebiasis than in the general population. The relevance of these findings to the pathogenesis of amoebiasis is not clear but the relationship may well not be a direct one, since hepatic iron stores were no larger in patients with liver abscesses than in subjects without.

Adult↗
PubMed1982

Intrathecal ketamine with preservative - histological effects on spinal nerve roots of baboons.

Ketamine, an analgesic-cataleptic drug, provides pain relief without respiratory depression. Ketamine with the preservative benzethonium chloride 0.1 mg/ml was injected intrathecally into 4 baboons under Ketamine anaesthesia. A control group of 2 baboons received intrathecal saline. No assessment as to relief from experimental pain was possible, but all the baboons recovered normally from anaesthesia and were found moving about in their enclosures without gross evidence of neurological impairment. No adverse reactions were noted. One month after the intrathecal injection the baboons were sacrificed, and an autopsy was performed within 30 minutes. No macroscopic abnormally of the cord was noticed. Microscopic examination revealed oedema of a few nerve roots in all animals irrespective of whether ketamine or saline had been injected intrathecally. No other changes attributable to ketamine were seen, and its is therefore concluded that, in the doses given, intrathecally injected ketamine would seem to be safe.

Animals↗
PubMed1982

Effects of intrathecal saline and ketamine with and without preservative on the spinal nerve roots of monkeys.

Ketamine, a cataleptic analgesic substance which theoretically may block pain receptors in the spinal cord, providing pain relief without respiratory depression, was injected intrathecally with or without benzethonium chloride 0.1 mg/ml (a preservative) into 8 monkeys under anaesthesia. Two monkeys received saline (control group). No assessment as to relief from experimental pain was possible. All Monkeys recovered normally from anaesthesia and were found moving about in their enclosures without gross evidence of neurological impairment. No adverse reactions were noted. Ten days after the subarachnoid injection the monkeys are sacrificed. Autopsy was performed within 30 minutes. No macroscopic abnormality of the cord was noticed. Microscopic examination revealed oedema of a few nerve roots in all animals, irrespective of whether ketamine or saline was injected intrathecally. Focal degeneration with loss of myelin and axoplasm was observed within a solitary nerve root in 2 monkeys that had received ketamine, 1 with and 1 without preservative. However, in these animals lumbar puncture proved difficult and bloody taps ensued. Hence trauma could have been a contributing factor in these 2 cases. None of the other monkeys showed these changes, regardless of group.

Animals↗
PubMed1976

The heart in cardiomyopathy: a postmortem study.

Thirty-five consecutive cases of cardiomyopathy were studied at postmortem examination. The morbid anatomical changes found in the heart are described, with particular reference to ventricular hypertrophy. Contrary to most views, right ventricular predominance is found to be common in cardiomyopathy as seen in Blacks in and around Durban. No apparent couse for predominant right ventricular hypertrophy was found in this study.

Adolescent↗
PubMed1975

Endemic tropical sprue in Africa.

Twenty-four patients have been found who appear to have endemic tropical sprue, with malabsorption on biochemical, radiological and histological grounds. Patients with the tropical sprue syndrome responded equally well clinically and biochemically to folate and tetracycline. Jejunal histology responded least well to treatment. It is suggested that as more Gastrointestinal Units are opened, especially in humid sea level areas in Africa, more cases of endemic tropical sprue will be found.

Adolescent↗