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S Kamakura

Publications and source records attributed to S Kamakura.

115 records · Page 7Linked to original sources
PubMed1982

The mechanism of A-V conduction delay in A-V nodal gap.

Initial block in the His-Purkinje system was demonstrated in 17 of 71 patients during atrial extrastimulus testing. Of the 17 patients who demonstrated initial block in the His-Purkinje system, ten patients had A-V nodal gap (a type 1 gap). Of these ten patients, progressive increase in A-V nodal conduction was responsible for a resumption of A-V conduction in six patients, dual pathways within the A-V node was responsible in three patients, and the presence of an extra nodal pathway of the A-V node was responsible in one patient.

Atrial Fibrillation↗
PubMed1981

A possible mechanism of reciprocating tachycardia initiated by critical shortening of the atrial cycle length in concealed Wolff-Parkinson-White syndrome. Report of a case.

Reciprocating tachycardia in a patient with concealed septal accessory pathway is described. His arrhythmia is characterized by incessant form of tachycardia which is not initiated by a triggering extrasystole but by critical shortening of P-P interval. Electrophysiological studies showed that the occurrence of the reciprocating tachycardia was dependent on atrial pacing rate. By comparing effective refractory period of the atrium, retrograde effective refractory period of the accessory pathway, the conduction time over the reentrant circuit and the difference of conduction time via normal conduction system and via the accessory pathway to the ventricular end of the accessory pathway, it was found that an atrial echo was elicited only at atrial pacing rates at which the difference of conduction times to the ventricular end of the accessory pathway was greater than the effective refractory period of retrograde accessory pathway. These observations suggest that the initiation of the tachycardia in this patient is related to a critical antegrade conduction delay necessary for complete recovery of the ventricular end of the accessory pathway from the preceding antegrade depolarization.

Adolescent↗
PubMedDate not supplied

Haplotype structures of the UGT1A gene complex in a Japanese population.

Genetic polymorphisms of UDP-glucuronosyltransferases (UGTs) are involved in individual and ethnic differences in drug metabolism. To reveal co-occurrence of the UGT1A polymorphisms, we first analyzed haplotype structures of the entire UGT1A gene complex using the polymorphisms from 196 Japanese subjects. Based on strong linkage disequilibrium between UGT1A8 and 1A10, among 1A9, 1A7, and 1A6, and between 1A3 and 1A1, the complex was divided into five blocks, Block 8/10, Block 9/6, Block 4, Block 3/1, and Block C, and the haplotypes for each block were subsequently determined/inferred. Second, using pyrosequencing or direct sequencing, additional 105 subjects were genotyped for 41 functionally tagged polymorphisms. The data from 301 subjects confirmed the robustness of block partitioning, but several linkages among the haplotypes with functional changes were found across the blocks. Thus, important haplotypes and their linkages were identified among the UGT1A gene blocks (and segments), which should be considered in pharmacogenetic studies.

Asian People↗