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Biomedical subjects

S Kannuki

Publications and source records attributed to S Kannuki.

28 records · Page 2Linked to original sources
PubMed1992

Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells.

An autopsy case of anaplastic ganglioglioma in the brain stem of a 12-year-old girl is reported. The ill-defined tumor involved the right cerebellar peduncle, medulla oblongata and upper cervical spinal cord, and showed mixed proliferation of many ganglioid cells and atypical pilocytic astrocytes with necrotic areas. Immunohistochemical studies revealed the presence of chromogranin A in most ganglioid cells and of metenkephalin in some large ganglioid cells. Glial cells were positive for glial fibrillary acidic protein and vimentin. Ultrastructurally, numerous dense-core granules of 90-220 nm in diameter were demonstrated in ganglioid cells and abundant glial filaments in glial cells. High neurosecretory activity in neuronal cells, suggested by chromogranin-immunoreactivity and dense-core granules, seems to be the most characteristic property of ganglion cell tumors.

Brain Neoplasms↗
PubMed1991

Effects of triflusal and acetylsalicylic acid on microthrombi formation in experimental brain ischemia.

Ischemic cerebral infarcts induce hypercoagulation and microthrombosis, thus leading to vessel occlusion and reduction of local cerebral blood flow. Antiaggregant therapy can reduce the formation of microthrombi. We tested the effect of acetylsalicylic acid (ASA) and triflusal (2-acetoxy-4-tri-fluoromethylbenzonic acid) on the formation of microthrombi after middle cerebral artery (MCA) occlusion. Six groups of rats, each consisting of six animals received either ASA or triflusal at dosages of 12.5, 25 or 50 mg/1,000 g b.wt./day. One control group was sham-operated, in another control group MCA occlusion was performed; both groups received no therapy. The number of microthrombi was counted 7 days after MCA occlusion on paraffin sections. The highest number of microthrombi was found in the group with MCAO and without therapy (mean 28 microthrombi/animal). In treated groups a reduction of the number of microthrombi could be stated. The strongest reduction was achieved in the group treated with 12.5 mg triflusal (mean 5.2). No statistic significant difference in the number of microthrombi was found between the groups treated with 12.5 mg triflusal and 50 mg ASA (mean 8.7) compared to sham-operated control animals (mean 4.3, p greater than 0.05). Treatment with 12.5 mg triflusal was superior to 50 mg ASA in preventing microthrombi formation (p less than 0.05). These results indicate, that in experimental brain ischemia the number of microthrombi can be effectively reduced by application of antiaggregatory drugs.

Animals↗
PubMed1991

Coexistence of intracranial and spinal meningiomas--report of two cases.

The authors report two rare cases of multiple meningiomas in both the intracranial and spinal regions. A 64-year-old female presented with a right sphenoidal ridge meningioma and a cervical extramedullary meningioma. Tumor histology was transitional and vacuolated types, respectively. The tumors were removed successfully in two stages, craniotomy then laminectomy 3 months later. A 62-year-old female presented with a right sphenoidal ridge meningioma (meningotheliomatous type) which was totally removed. An extramedullary spinal meningioma became symptomatic 33 months later, which was also removed totally. The meningiomas in the first case had different subtypes, but immunohistochemical characteristics including microcyst formation were similar. The second case had meningiomas of the same subtype with similar characteristics, but different fibrous septum development. Multiple meningiomas, even in different compartments of the central nervous system, may have common characteristics.

Biomarkers, Tumor↗
PubMed1990

[Thrombus propagation and venous drainage disturbance in cerebral sinus-vein thrombosis--38 autopsied cerebral sinus-vein thrombosis].

38 autopsied cases of cerebral sinus-vein thrombosis (CSVT) in our institute were studied. In this study, special attention was paid for the evolution and fate of venous thrombus. 18 cases showed hemorrhagic infarction or intracerebral hematoma (group 1; G 1). In contrast, no cerebral parenchymal changes were observed in the other 20 cases (group 2; G 2). In 13 of 18 cases of G 1, superior sagittal sinus (SSS) were thrombosed. 10 of these 13 cases showed thrombosed cerebral cortical veins (CV) or deep cerebral veins (DV). In contrast, none of 16 cases of G 1 with thrombosed SSS showed thrombosed CV or DV. All cases of the solitary thrombosis of CV or DV (each 2 cases) belong to G 1. Venous thrombi were divided into three stages according to its process of organization; recent thrombus (R), hyalinized thrombus (H), organized thrombus (O). In the venous thrombi of G 1, 6 cases were R, 6 were partly H, 6 were partly 0. In addition to O, R and H were also observed in group O. Distribution of various stage of thrombus in same case suggested that gradual thrombus evolution had occurred before or after the clinical onset in CSVT. This study suggested: (1) CV or DV occlusion may play an important role for the advent of cerebral parenchymal changes in CSVT. (2) Gradual thrombus evolution after the onset is one of possible causes of slow clinical deteoration after the onset. Therefore, prevention of these thrombus propagation with anti-platelet drugs or fibrinolotic therapy should be recommended for the treatment of CSVT. On the contrary, hyperosmolar agents and diuretics may produce potential risk of dehydration, and as a result, accelerate secondary thrombus extension.

Adolescent↗
PubMed1990

[A case of ganglioglioma with choked disc].

A case of ganglioglioma associated with choked disc is reported. A 19-year-old girl was admitted to our hospital because of blurred vision. Neurologically, the patient had nothing but choked disc. The CT showed a large cystic mass with calcification in the left parieto-occipital lobe. The MRI revealed that the cyst was delineated by a membrane and that its dorsal side was solid, showing enhancement by Gd-DTPA. Cerebral angiography showed no tumor stain. Left parieto-temporo-occipital craniotomy was performed and the tumor was removed subtotally. Histopathological examination demonstrated the typical pattern of ganglioglioma. The most common symptom of ganglioglioma is convulsions. Symptoms of increased intracranial pressure have been reported sporadically in the literature. It was clinically noted that the cause of the increased intracranial pressure in this patient was enlargement of the cyst associated with ganglioglioma.

Adult↗
PubMed1989

[Evolution of venous cerebral infarction and brain edema--an experimental study of sagittal sinus obstruction].

Superior sagittal sinus with/without neighboring venous system of 36 mongrel cats were occluded by cyanoacrylate polymer after i.v. administration of Evans-blue (EB). Thereafter, the cats were sacrificed 1, 3, 6, 12, 24, 72 or 120 hours after sinus-vein occlusion. According to the degree of occluded region, the cats were divided into two groups; group A (GA) and B (GB). GA showed only superior sagittal sinus occlusion, while many cortical veins were also occluded in GB. No EB nor histological changes were found in 13 cats of GA and 4 sham operated cats, while EB distribution was observed in all 20 cats of GB. The other 3 cats of GA showed a little EB in gyrus lateralis. EB distribution of GB were divided into two types. Type 1 showed EB mainly in the cortical gray matter, while type 2 showed massive EB extravasation in the white matter as well. Edematous changes with gliosis in its resolution phase, were observed in type 1. In addition, EB free zone was formed along with U-fiber zone (cortico-medullary junction) in the cats of later phase (72 hours after occlusion). The findings of EB extension in the type 1 means the existence of blockage against edema evolution from cortex toward subcortical white matter. The cats of type 2 showed fulminant hemorrhagic changes which appeared depend on time interval. Although occurrence of pathological changes were rather earlier than that of cases of clinical cerebral sinus thrombosis, this pathological findings demonstrated the typical character of venous hemorrhagic infarction. In this paper, the similarity and difference between this model and clinical case of sinus-vein thrombosis were discussed. And the possible function of the U-fiber zone in the corticomedullary junction against edema evolution was suggested.

Animals↗
PubMed1986

[Intracranial lipoma of the temporal lobe--report of a case and review of the literature].

A 52-year-old female was admitted to our clinic with chief complaint of headache since 2 months ago. Plain computed tomography (CT) revealed low density mass in her right temporal lobe beneath the sylvian fissure with mean Hounsfield number of -52. On admission, no neurological deficit was found. This low density mass had no enhancement region. No abnormal finding was seen in plain skull roentgenogram and right carotid angiography. No epileptic pattern was found electroencephalographically. Right fronto-temporal craniotomy and total removal of tumor was performed to confirm the histological nature of this tumor. The tumor was elastic soft with yellowish color and totally removed. Histological examination revieled typical fatty cells and many capillaries. Her postoperative course was uneventful and was discharged with no neurological deficit. Intracranial lipoma is one of rare brain tumors with incidence of 0.03% or 0.046% in all brain tumor. These tumors are most frequently located in the midline structure, especially in the corpus callosum. After introduction of CT scan, however, lipomas of the extraaxial locations are also reported. From review of literature, location of the lipomas may be divided into 2 groups: the one is located in the midline or paramedian structures of the brain and the other is the extraaxial region such as the sylvian fissure or the cerebellopontine angle. The former group is often associated with anomalies of the central nervous system related to dysraphism. However, the latter group is seemed to have rare association with dysraphism.(ABSTRACT TRUNCATED AT 250 WORDS)

Brain Neoplasms↗
PubMed1985

[Recurrence of cerebral aneurysm after neck clipping--report of a case and review of literature].

A case of recurrent cerebral aneurysm after complete neck clipping is reported. A 38-year-old man was admitted to our service 14 days after attack of subarachnoid hemorrhage. On admission, ruptured left middle cerebral artery aneurysm with intercerebral hematoma and non-ruptured right anterior cerebral artery aneurysm were revealed by radiological examinations. Neck clipping was successfully performed to both of aneurysm and aneurysm was completely disappeard in the postoperative angiographical study. Postoperative course was also uneventful and he was discharged with slight right hemiparesis and motor aphasia. Thirteen months after the neck clipping, however, he was readmitted to our hospital with attack of subarachnoid hemorrhage. After admission, a new aneurysm was noted just under the clip at the right anterior cerebral artery. Neck clipping against this aneurysm was performed by reopening the craniotomy. For his postoperative normal pressure hydrocephalus, ventriculoperitoneal shunt was performed at one month after neck clipping. Postoperative course was uneventful and discharged. From review of literature, it was presumed that hemodynamic stress in the site of aneurysm and injury of arterial wall by the clip may be two major factors as a cause of recurrent aneurysm formation. In our case, possibility of the latter cause was suggested.

Adult↗