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Biomedical subjects

S Kantor

Publications and source records attributed to S Kantor.

11 recordsLinked to original sources
PubMed1990

Simaomicin (LL-D42067), a novel antibiotic from Actinomadura madurae. I. Taxonomy, fermentation and biological activity.

A new antibacterial antibiotic, designated simaomicin alpha (LL-D42067 alpha) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067 was identified as a new subspecies of Actinomadura madurae. Simaomicin alpha demonstrated potent activity against Gram-positive bacteria and was active in vivo against a variety of Eimeria species causing coccidiosis in chickens.

Animals↗
PubMed1990

In vivo effects of biosynthetic chicken growth hormone in broiler-strain chickens.

Two experiments were conducted to examine the effects of growth hormone (GH) in growing chickens older than broiler age. In experiment 1, 8 week old male (heavy "broiler" type strain) chickens received daily injections of either biosynthetic chicken GH or an implant of biosynthetic bovine GH for 3 weeks. Neither growth rate (daily weight gain) nor the feed:gain ratio was influenced by either preparation of GH. However, an increase in breast muscle was observed in birds receiving the higher dose (250 micrograms/kg/day) of chicken GH. No changes were observed with chicken GH treatment on the weights of the fat pad, heart, gizzard and shank bone or on shank bone length or on plasma concentrations of free fatty acids. Experiment 2 employed 12 week old male, heavy strain, chickens with biosynthetic chicken GH being administered via Alzet osmotic pumps. In this study, GH (50 micrograms/kg/day) increased growth rate, body weight, pectoralis (breast) muscle weight, adipose tissue weight, bursa Fabricius weight and the plasma concentrations of free fatty acids. It is concluded that GH can influence carcass composition and growth in older chickens.

Aging↗
PubMed1988

The effect of 13-cis retinoic acid on hematopoiesis in human long-term bone marrow culture.

The modulatory effect of 13-cis retinoic acid (RA) on the growth, differentiation and function of hematopoietic cells in human long-term cultures was studied. RA (5 X 10(-8) M) induced enhancement of myeloid progenitor cell growth in the non-adherent layer throughout 6 weeks of incubation while it did not affect the number of myeloid progenitors in the adherent layer. The vitamin did not alter the differentiation pattern of colony forming unit-culture (CFU-C). The addition of RA to cultures for 5 weeks did not alter the cellular composition of the adherent layer. Prolonged exposure of hematopoietic cells to RA did not affect the functional activity of neutrophils and macrophages, i.e. the cells were active in phagocytosing Candida albicans (CA).

Bone Marrow Cells↗
PubMed1978

Post-thyroidectomy thyrotoxicosis.

94 patients with postoperative recurrent hyperthyroidism were evaluated for duration of remission, goitre size, and response to radio-iodine (131I). 6 patients required 131I therapy within twelve months of operation--5 had large remnants because of inadequate surgery. 57% of patients relapsed within 5 years, but 16% relapsed after 20 years and 8% after more than 30 years. Estimated goitre weights ranged from 4 g to 65 g, and goitre size was unrelated to the duration of remission. All patients were treated with 131I. 23% of the patients became hypothyroid in the first postoperative year and 10% in the second year. The results indicate that postoperative thyrotoxicosis can recur decades after operation. Operation seems to sensitise the thyroid to the early effects of radiation by 131I.

Adult↗
PubMed1975

Relationship of pasture rotation to acquisition of gastrointestinal nematodes by sheep.

In a study of the relationship between pasture rotation in Illinois and acquisition of nematodes (mostly Haemonchus contortus) and body weight gains by lambs grazing with their ewes, 2 pasture rotation systems were tested. (1) Lambs and ewes were rotated through a series of 12 alfalfa-bromegrass-lespedeza pastures, each pasture being grazed for 3 to 4 days and rested for 5.5 weeks; 4 complete rotations were done during a 168-day grazing season. (2) Lambs and ewes were moved every 2 days, and 3 complete rotations of 50, 42, and 54 days, respectively, were done during the 146-day grazing season. The lambs under rotation had more nematodes and gained less weight than nonrotated control lambs, although rotation increased the amount of pasturage. Rotation is not recommended to control nematode parasitism of sheep in Illinois.

Animals↗
PubMedDate not supplied

Efficacy of maduramicin against ionophore-tolerant field isolates of coccidia in broilers.

Maduramicin ammonium was given at 2.5-8 ppm in the feed to broilers experimentally infected with coccidia recently isolated from broiler farms where ionophores had been used for several years. Infection pressure varied from mild to severe in five trials: mortality in unmedicated controls ranged from 0 to 59%, intestinal lesion scores were high, and weight gain was depressed by the infections. The cultures of Eimeria were partly resistant to ionophores: birds medicated with monensin at 100-121 ppm had only modest reductions in lesion scores and incomplete protection against weight loss or mortality. Control of infections by maduramicin was significant at 4 ppm but best at 5-7 ppm. Maduramicin was more effective than monensin or narasin, but about the same as salinomycin, in reducing lesions and mortality and in protecting performance. Maduramicin was well tolerated within the dose range of 5-7 ppm.

Animal Feed↗