Biomedical subjects

S Karouji

Publications and source records attributed to S Karouji.

5 recordsLinked to original sources

PubMed1987

NK activities and HNK-1+ cells in familial polyposis coli.

Although natural killer cells are thought to play a major role in surveillance against tumor development, no systemic studies on natural killer cells and their activities have been reported in familial polyposis coli in which cancer always develops at an early age. Natural killer activities and natural killer cells were studied in 14 patients with familial polyposis coli. Peripheral blood lymphocytes from familial polyposis coli showed normal cytotoxicities against K562 cells, P4788 cells derived from colon cancer and Chang cells. The number of natural killer cells in peripheral blood lymphocytes identified by an immunofluorescence antibody method and that in gut tissue by immunoperoxidase staining using anti-HNK-1 monoclonal antibody were comparable to those seen in normal controls. These results led to the following conclusion: it seems unlikely that a deficiency or impairment of natural killer activity is one of backgrounds for the development and subsequent malignant change of adenomas in familial polyposis coli.

Adenomatous Polyposis Coli↗

PubMed1980

[In-vitro motility studies on the strips of the canine gallbladder (author's transl)].

In-vitro motility of the gallbladder was investigated in the circularly cut full thickness strips obtained from 19 mongrel dogs. The present study was undertaken to determine an appropriate size of the strips for observation and to know any difference, if exists, between motilities of the strips prepared from the neck, body and fundus. Recordings were made on a pen chart recorder using an isometric tension system. The results obtained were as follows. 1) The most appropriate size of the specimens to examine the changes of contractile dynamics was 5 mm in width and 15 mm in length. 2) The strips from three parts of the gallbladder showed similar rhythmic and tonic spontaneous contraction patterns.

Animals↗

PubMed1980

[A photo-optical observation of gallbladder motility in dogs (author's transl)].

A photo-optical observation of gallbladder motility was made with a cholangiography on 38 mongrel dogs. The whole area, the sectional length were calculated from the series of roentgenograms, and compared the control value (100) before caerulein administration with the values (percentage of the control value) after caerulein administration. The results obtained are as follows. 1. Preparatory experiments indicated that lateral view is most suitable and intravenous administration of caerulein is more effective. Duration of X-ray discharge was decided as every 1 minute for initial 30 minutes after caerulein administration and every 5 minutes for following 60 minutes. 2. On experiments performed on the above-mentioned condition, there were two types of gallbladder motility. A typical type (12 cases): The length of fundus had most close correlation with the change of the gallbladder area, next was body and neck had less close correlation. The longitudinal length had more less close correlation than the sectional transverse length. An atypical type (8 cases): The longitudinal length had more close correlation with the change of the gallbladder area than the sectional transverse length. 3. By analysing the mean values of a typical type, the gallbladder area (y) could be expressed by the sectional length (x) as follows: neck: y=1.68x -- 68.1 body: y=1.81x-80.0 fundus: y=1.48x-45.4 longitudinal: y=1.83x-88.9

Animals↗

PubMed1980

[In-vitro motility studies on the strips of the human gallbladder (author's transl)].

The influence of inflammation on the motility of the human gallbladder was investigated through an in-vitro experiment. Motility of longitudinally cut strips from 50 patients were examined by the same method as described in our previous articles. We pathohistologically classified the severity of the inflammation of the specimens into four grades: grade 0 is normal, grade I, slightly inflamed; grade II, moderately inflamed; grade III, highly inflamed. Relationships between the grade of inflammation and the motility of the strips were summarized as follows. 1) In grade 0 cases, the strongest tonic contractions were observed in the strips from the fundus. This tendency was also found in cases of grade I and II but III inflammation. 2) The tonic contractions of the strips from the fundus or body decreased along with the grade of the inflammation. 3) In any strips, the frequency of the rhythmic contractions decreased progressively with the grade of the inflammation. 4) The amplitudes of rhythmic contractions of the strips with grade I and II inflammation were larger than those of grade 0 inflammation.

Adult↗

PubMedDate not supplied

Personal computer program for processing data from patients with colo-rectal cancer.

A personal computer has been used to save labour and time in handling the data of patients with colo-rectal cancer. The program was written in N-88 BASIC to run on PC-8800 series equipment (PC-8801 processor, PC-8881 floppy disk unit, PC-8822 printer and PC-8853 CRT) manufactured by NEC Co., Ltd. This program enables data on patients to be easily input and instantly expressed. Data input is done by the cursor method, making input very quick and straightforward. Changes, additions and deletions to the data are very easy and output can be made to both display and printer. Data searching is done according to the enquiry and a print out can be obtained at any time for ready-to-read information. The Japanese nation-wide protocol for colo-rectal cancer is used as the basis for the system, providing almost complete linking with the national registry for any statistical data.

Colonic Neoplasms↗