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Biomedical subjects

S Kasperek

Publications and source records attributed to S Kasperek.

At least 19 recordsLinked to original sources
PubMed1989

[Hoffmann's syndrome. The role of neurologists in the diagnosis of hypothyroidism].

In a mason aged 48 years gradually hardness, rigidity and painful muscle spasms, slowness of movements and awkwardness with progressing difficulties in walking developed. Only after several months of observation the finding of pseudo-myotonia suggested the diagnosis of Hoffmann's syndrome during hypothyroidism. In a number of neurological syndromes and in unclear muscular signs it is useful to consider hypothyroidism in the differential diagnosis.

Diagnosis, Differential↗
PubMed1983

On the mechanisms of ATP-induced and succinate-induced redistribution of cations in isolated rat liver cells.

1. The ability of external ATP to induce calcium uptake in isolated rat liver cells was further characterized. Stimulation of calcium uptake was specific for ATP, other nucleotides or ATP metabolites had no comparable effect. ATP was dephosphorylated while stimulating calcium uptake, but there was no stoichiometry between ATP hydrolysis and calcium uptake nor did dephosphorylation depend on calcium concentration. ATP acted from outside and was dephosphorylated by an ecto-ATPase of the cells. 2. In addition to its direct action, ATP enhanced succinate-dependent calcium uptake in a cooperative fashion. This is best explained by different sites of action. ATP increases cell membrane permeability while succinate stimulates uptake into mitochondria. 3. ATP was able to lower Na+ and K+ gradients and the pH gradient between cells and incubation medium. Increasing calcium concentration counteracted this effect though calcium uptake was then stimulated. 4. Succinate alone did not affect monovalent cation gradients but raised the pH gradient. It partially counteracted the ATP effects on these gradients. 5. Since catecholamine-like actions of ATP may be mediated by an increase in cytoplasmic calcium concentration, the action of extracellular ATP can be taken as a model to study the role of calcium as a transmitter of hormone actions. From interdependence between ATP-stimulated and succinate-stimulated calcium uptake, conclusions can be drawn on the resulting cytoplasmic calcium concentration and its effect on plasma membrane permeability.

Adenosine Triphosphate↗
PubMed1982

[Many-year course of systemic lupus erythematosus with cerebral symptoms].

During 20 years of disease duration in the reported woman aged 47 years at the time of death articular involvement was followed by cardiac involvement and after labour renal signs appeared. Cerebral signs developed about 11 years before her death and manifested themselves as several typical strokes. The observed systemic affections, including the neurological signs, responded favourably to immunosuppression. Postmortem examination of the brain demonstrated numerous ischaemic foci, including a large cerebellar infarction, due to proliferative changes in the walls of cerebral and meningeal vessels.

Cerebellar Diseases↗
PubMed1979

[Neurological syndromes in the course of systemic lupus erythematosus].

Seven cases of SLE with concomitant neurological syndromes are reported. In 2 cases brain stroke with right-sided hemiplegia and aphasia developed, in the remaining cases brain-stem stroke with subarachnoid haemorrhage, progressive hemiparesis and signs of intracranial hypertension, chorea, status epilepticus in terminal uraemia were observed. In one case myasthenia coexisted. Severe neurological syndromes were preceded by signs of involvement of other organs and in most cases by low-grade signs of central nervous system involvement. Treatment with corticosteroids and immunosuppressants resulted in significant improvement without complete remission. A retrospective survey of clinical material showed that modern therapeutic methods have improved the prognosis in systemic lupus erythematosus independently of central nervous system involvement.

Adult↗
PubMed1979

[Ocular manifestations of myotonia atrophica].

In a 55-year-old male with a history of over 20 years of exposure to lead clinical, electromyographic and histological investigations demonstrated myotonic dystrophy. Cataract and high-grade concentric narrowing of the visual field were found bilaterally. The latter change has been reported sporadically in this disease. Detailed laboratory investigations failed to confirm lead intoxication. No genetic background has been elicited which may suggest the possibility of toxic exogenous factors in this disease but is insufficient for accepting this possibility.

Diagnosis, Differential↗
PubMed1975

Criteria of viability of isolated liver cells.

36.4 +/Various cellular parameters were measured with regard to their usefulness as criteria of viability of isolated cells. Stainability by trypan blue and release of lactate dehydrogenase indicate only severe irreversible damage of cells. Neither endogenous respiration nor even the ATP/ADP ratio is a sensitive criterion of viability. On aging of cells, the ATP/ADP ratio remains high, even though the membrane potential, the intracellular K concentration and the content of adenine nucleotides decrease considerably. A sensitive, easily performed test is the stimulation of cellular respiration by 1mM succinate. Only a damaged plasma membrane allows succinate permeation of a rate sufficient to stimulate respiration. The membrane potential and the intracellular Na and K concentrations are the most sensitive criteria of viability, since they indicate the earliest changes on aging. (For freshly isolated cells, we found a membrane potential of 36.4 "/- 3.4 mv [n = 5], an intracellular K concentration of 109.0 +/- 9.1 mM, and an intracellular Na concentration of 47.0 +/- 13.4mM.) The incorporation of [14C]uridine also sensitively reflects cellular damage.

Adenosine Diphosphate↗
PubMedDate not supplied

[Micturition syncope: a peculiar cause of diagnostic doubt].

A 22-year old healthy man lost consciousness during urination in standing after night's sleep. He fell down to the floor without convulsions. A physician present by chance found on bradycardia. A 24-hours ECG monitoring disclosed an almost permanent sinus bradycardia (50-55 per minute). CT showed an arachnoid cyst at the base of the left temporal lobe without mass effect. In EEG only single slow waves above left temporal region were revealed. It seems, the cyst was found by chance and had no any pathogenetic relevance to the syncope. However, the presence of a structural change of the brain had not been described in micturition syncope till now and this makes careful differentiation from epileptic seizure essential. During the following 2 years the patient was well and the episode did not recur again. The control CT and EEG remained unchanged. Data from literature about syncope in association with micturition also in older persons, in majority women with chronic illnesses, are cited.

Adult↗