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Biomedical subjects

S Kavukcu

Publications and source records attributed to S Kavukcu.

13 recordsLinked to original sources
PubMed2006

Renal medullary changes in renal allograft recipients with raised serum creatinine.

OBJECTIVE: To test the hypothesis that the renal medulla may reflect rejection related changes and thus have a predictive value in the assessment of acute renal allograft rejection or chronic graft damage. METHODS: 75 post-transplant biopsies from 57 patients were scored according to the Banff 1997 scheme. The biopsies with adequate cortical and medullary tissue (n = 23) were selected and medullary tissues were reviewed for rejection related lesions except intimal arteritis. Chronic damage was determined by image analysis depending on periodic acid-methenamine silver (PAMS)-Masson trichrome (MT) staining. Medullary and cortical changes were compared. RESULTS: Interstitial inflammation and tubulitis were more frequent and severe in the cortex (p<0.001). Medullary tubulitis was associated with intimal arteritis (p = 0.003, r = 0.598). Medullary interstitial inflammation (n = 8) and tubulitis (n = 4) were associated with cortical borderline changes (n = 5) or allograft rejection (n = 3). The sensitivity, specificity, and positive and negative predictive values of medullary inflammatory changes in predicting cortical allograft rejection were 43%, 69%, 37%, and 73%, respectively. A significant association was observed between medullary MT-SAP and cortical PAMS-SAP values (p = 0.02, R(2) = 0.23). CONCLUSIONS: Acute rejection related lesions are more common and severe in the cortex, and the renal medulla does not sufficiently reflect cortical rejection. The positive and negative predictive values of medullary changes for allograft rejection are low, and medullary inflammation is not a reliable indicator of allograft rejection. Increased medullary fibrosis is correlated with chronic cortical damage.

Adolescent↗
PubMed2006

Quantitative digital histochemistry with methenamine silver staining in renal allograft biopsies excluding pure chronic allograft nephropathy cases.

Deterioration of renal function is correlated with irreversible damage in chronic diseases. Recently we described a digital quantitative histochemistry method, relying on periodic acid methenamine silver (PAMS) staining to determine the chronic renal lesions. This index was strongly correlated with progressive deterioration of renal function in grafts with chronic allograft nephropathy (CAN). Herein the method has been applied to a cohort of renal allografts which were biopsied for various reasons, we sought to highlight its value to quantify chronic graft damage. Forty-four renal allograft biopsies from 37 patients with elevated serum creatinine values (SCr) underwent light microscopic image analysis (Mediscope, Dokuz Eylül University, Clinical Engineering Department, Izmir, Turkey) of the PAMS-stained area percentage (SAP). SCr was recorded at four intervals to overcome acute effects: the under SCr value before (SCr1) and after a biopsy within 3 months (SCr3), SCr at the time of the biopsy (SCr2), and the latest value (SCr4). The PAMS-SAP scores were strongly associated with increased interstitial fibrosis and tubular atrophy Banff scores (Kruskal-Wallis test, P = .006 and P = .003, respectively). There was a moderate positive correlation between PAMS and SCr3 (Pearson correlation test, P = .04, r = .312), and a strong positive correlation between time from transplantation to biopsy (Pearson correlation test, P << .000, r = .532). The present results show that PAMS-SAP seems to be of value to quantify renal scarring in allograft biopsies, reflecting four compartments. The strong correlation with time is noteworthy especially as a probable reflection of aging of the renal allograft.

Anti-Infective Agents, Urinary↗
PubMed1998

Could conductivity be used as a parameter in urinalysis?

Conductivity is a non-linear function of electrolyte concentration in solutions and could be used as an indirect method. The aim of this study was to determine the feasibility of urine conductivity measurement, which is a simple, cheap and not time consuming method, in the evaluation of renal functions. Seventy-two patients whose primary diseases were not taken into consideration were enrolled in this study. First morning urine specimens were obtained from all the patients and evaluated for osmolality, conductivity, pH, specific gravity, protein, creatinine, urea, uric acid, glucose, sodium, potassium, chloride, inorganic phosphate and calcium levels. There was a significant positive relation between osmolality and creatinine, urea, sodium, potassium, chloride, inorganic phosphate, uric acid, conductivity and specific gravity. Conductivity was also determined to be positively related to osmolality (r: 0.390, p < 0.01), sodium (r: 0.326, p < 0.01) and uric acid (r: 0.345, p < 0.01). The patients were grouped as those with a urine osmolality of less or more than 290 m Osm/kg. H2O (group A and B respectively). Urine conductivity was 6.84 +/- 5.35 (0.16-23.2) mScm-1 in group A and 10.6 +/- 5.25 (0.12-192) mScm-1 in group B. The difference was statistically significant (p = 0.005). When the spectrum of conductivity values were evaluated separately in each group, 74% of the patients in group A and 33.9% of the patients in group B were determined to have a conductivity level of less than 7.338 mScm-1. In conclusion, urine conductivity has a positive relation with osmolality. In addition, while osmolality and specific gravity are effected by many non-electrolyte molecules, conductivity is only related to sodium and uric acid concentrations. In addition, urine osmolality and conductivity levels could be used to interpret the concentration of uncharged glucose molecules. These results suggest that conductivity could be used as a parameter in routine urinalysis.

Child↗
PubMed1998

Investigation of relationship between idiopathic hypercalciuria and urinary enzyme activities.

In patients with uncomplicated idiopathic hypercalciuria renal function is normal except for increased renal calcium excretion. In this study, the level of fractional urinary enzyme excretion was assessed in relation to calciuria. Fourteen patients with a mean age of 5.8 +/- 0.8 years who had daily urinary calcium excretion more than 4 mg/kg and with otherwise normal renal function tests were included in the study. None of the patients manifested either renal calculus or nephrocalcinosis. Fourteen normal children with a mean age of 5.4 +/- 0.74 were included in the control group. The level of the urinary N-acetyl beta-D glucosaminidase (NAG) to creatinine ratio, fractional aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) excretion were not significantly different compared to the control group (p > 0.05). The patients were subdivided according to the type of hypercalciuria. The levels of NAG/creatinine ratio, fractional ALT, AST, ALP, LDH excretion were not significantly different in the absorptive type of calciuria group compared to the control group (p > 0.05). In conclusion, hypercalciuria during childhood which is 6.46 +/- 1.83 mg/kg/day is not related to the levels of NAG/creatinine ratio, fractional ALT, AST, ALP and LDH excretion in urine.

Calcium↗
PubMed1997

Adie's syndrome in childhood.

An 8-year-old girl with a history of mild amblyopia who had occlusion therapy, but her anisocoria went unnoticed, was studied. Old photographs of the patient were reviewed and a 0.1% pilocarpine test was performed. Review of her old photographs suggested that she had anisocoria at least since she was 3 years old. The 0.1% pilocarpine test confirmed a diagnosis of Adie's syndrome. In light of this case, it must be kept in mind that though rare, Adie's syndrome can be encountered in early childhood.

Adie Syndrome↗
PubMed1994

Comparison of serum and breast milk ferritin with some hematological parameters in the perinatal period.

Hemoglobin, hematocrit, serum iron, total serum iron binding capacity, transferrin saturation and ferritin levels of 27 pregnant women and their babies at delivery and at 8-10 weeks of age and of their mature breast milk were determined. Eighteen pregnant women with iron deficiency anemia and 9 healthy pregnant women as controls constituted the groups in this study. Excepting serum iron (p < 0.05) no significant differences were found between any of the remaining parameters in cord blood of the anemic and control groups. While the hematological parameters in sera of babies of the anemic and control mothers showed no significant differences at 8-10 weeks of age, the mean ferritin level at 8-10 weeks in breast milk of anemic mothers was significantly lower than of controls (p > 0.02). Besides, a significant relation (r:0.535) was found between the ferritin values of the cord blood and of the infants' sera at 8-10 weeks of age.

Anemia, Iron-Deficiency↗
PubMedDate not supplied

The importance of pulmonary function tests in adenotonsillectomy indications.

Children who had undergone adenotonsillectomy for recurrent adenotonsillitis showing no signs of clinical or radiological obstructive manifestations were evaluated with pulmonary function tests before, and one month after the operation. In relation to the result obtained by function tests, 60% of 45 cases (27) had the findings of mild obstructive pulmonary disease whereby these findings were in transient character that vanished after the operation. The following parameters were measured and found that they were all increased, mean FVC from 82.22 +/- 6.82 to 93.11 +/- 7.81 (p < 0.01), mean PEF from 77.60 +/- 8.38 to 88.60 +/- 5.57 (P < 0.01), mean FEVI from 74.28 +/- 11.68 to 90.15 +/- 7.28 (p < 0.01), mean FEF 25 from 71.44 +/- 11.53 to 83.53 +/- 6.40 (p < 0.01), mean FEF 50 from 69.53 +/- 14.53 to 84.37 +/- 7.72 (p < 0.01), mean FEF 75 from 70.08 +/- 12.15 to 85.48 +/- 7.15 (p < 0.01). In conclusion, pulmonary function tests could reveal the obstructive effects of adenotonsillar hypertrophy with no clinical or radiological obstructive findings, and could be useful in surgical indications of adenotonsillar hypertrophy dur to recurrent infections in children.

Adenoidectomy↗
PubMedDate not supplied

Coats' disease and calcification: a case report.

Intraocular calcification can rarely occur in Coats' disease. To our best knowledge, all previously reported cases with intraocular calcification had significant exudative detachment. We report an 11-year-old boy with unilateral Coats' disease who had only moderate, widespread subretinal exudation with a ridge located temporal to left macula without overt exudative retinal detachment. Ultrasonographic evaluation and orbital computed tomography revealed that the ridge was calcified. It should always be remembered that calcification may be present even in patients with a moderate form of Coats' disease.

Calcinosis↗