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Biomedical subjects

S Kaweski

Publications and source records attributed to S Kaweski.

7 recordsLinked to original sources
PubMed1997

Importance of separation of the nasopharyngeal and extradural spaces.

The extradural dead space must be separated from the nasopharynx to avoid a potentially lethal complication. This can be accomplished by a variety of methods involving vascularized flaps. However, the flap must be large enough to close the defect and it must be well vascularized. A case is presented to illustrate these important features.

Case Reports↗
PubMed1993

Diffusion versus iontophoresis in the transport of gentamicin in the burned rabbit ear model.

This experimental study demonstrates that iontophoresis can be used to transport biologically active gentamicin into auricular cartilage. Fifty female New Zealand White rabbits were divided into three groups: live controls with unburned ears, live animals with burn-injured ears (deep or partial-thickness), and euthanized animals with unburned ears. Each group was then divided into subgroups that received gentamicin transported by iontophoresis or diffusion. In ears subjected to iontophoresis, adequate gentamicin activity could be demonstrated only in the cartilage of euthanized animals with unburned ears and live animals with full-thickness burned ears. Diffusion did not transport a detectable level of gentamicin in any instance. Diffusion is ineffective in the transport of gentamicin and should not be used as a primary method of treatment for ear chondritis. Iontophoresis did not transport active gentamicin across partial-thickness burns, presumably because the migrating antibiotic molecules were dispersed throughout the body by the circulation. However, if the circulation is destroyed, as in a full-thickness burn, iontophoresis can move the biologically active gentamicin into the cartilage.

Animals↗
PubMed1991

Soft-tissue expansion in lower extremity reconstruction.

Soft-tissue expansion in the lower extremities is typically well tolerated. The more proximal one is--that is, the closer to the thigh and buttocks--the easier and less complication prone the expansion will be. It is another valuable technique for resurfacing the lower extremity and for reconstructing defects in contour and in skin character. There are limitations to this technique, which generally is most useful in late reconstructions. Intraoperative expansion has no place in lower extremity reconstruction. Soft-tissue expansion may be limited by an unsuitable geometry or the sheer size of defects. It should not be used next to open wounds. Soft-tissue expansion offers significant advantage in that the coverage of a defect will be replaced with tissue like that lost. Seldom does one see necrosis of advanced flaps, so that there is little risk of tissue loss in using this modality. There is an excellent vascularity to the flaps and an excellent character to the skin. In addition, in this cost-conscious era, soft-tissue expansion is quite cost effective, and in many cases the procedures can be conducted on an outpatient basis with a minimum of hospitalization, if any. With care to select patients properly, design carefully, and conduct expansion in a leisurely fashion, soft-tissue expansion offers a valuable means of reconstructing both large and small lower extremity defects.

Adult↗
PubMed1981

Detection of HLA-DRw specificities by mixed agglutination.

By means of mixed agglutination test with staphylococcal protein A indicator system, DRw antigens were studied on lymphocytes obtained from tonsils, peripheral blood and thymuses. Monospecific antisera to DRw 1, 2, 3, 6 and 7 which were preadsorbed with pooled platelets gave mixed agglutination titers of 300 or more against B cells of human tonsilar lymphocytes and peripheral blood lymphocytes. The DR phenotypes of human tonsilar lymphocytes and peripheral blood lymphocytes determined by mixed agglutination tests corresponded to those established by lymphocytotoxicity tests. Upon stimulation of thymocytes or T cells of peripheral blood lymphocytes by Con-A, DRw antigens became detectable by mixed agglutination tests. Simultaneous experiments on the stimulated T cells of peripheral blood lymphocytes by membrane fluorescence tests showed that 21-45% of the stimulated T cells possessed DRw antigens at a detectable level, while less than 2% of unstimulated cells were positive. These results indicated that DRw antigens are present in the subpopulation of T cells which may expand in the response to Con-A stimulation.

Agglutination Tests↗