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Biomedical subjects

S Kazukawa

Publications and source records attributed to S Kazukawa.

13 recordsLinked to original sources
PubMed1989

Meige's syndrome during long-term neuroleptic treatment.

Two patients developed difficulties in eyelid opening following long-term neuroleptic treatment of more than 6-8 years. Tardive dyskinesia and dystonia apart from the face were not found in either case. The symptoms fluctuated in their severities on a daily basis and were easily aggravated by various stimuli, e.g., stress, walking, reading and watching television. Electromyographic studies of their faces clearly indicated that the symptoms resulted from spontaneous blepharospasm and were analogous to idiopathic Meige's syndrome. Therefore, the patients' difficulties in opening their eyes were considered to be the so-called drug-induced Meige's syndrome and/or facial tardive dystonia. It must be stressed that this syndrome is extremely distressing to patients and is a severe complication accompanying a long-term neuroleptic treatment.

Adult↗
PubMed1989

Sleep spindles in twins.

Sleep spindle characteristics and spindle power periodicity were studied in 4 identical and 3 fraternal twin pairs (mean age, 16 years). There were no significant genetic effects such as concordance between the identical twins and discordance between the fraternal twins for mean duration, mean amplitude and mean frequency of spindles. Spindle periodicity, which is correspondent to the sleep cycle, was visually more similar between the identical twins than between the fraternal twins. These observations suggest that the sleep cycle which is expressed by periodic appearance of spindle powers is genetically determined. On the other hand, some spindle characteristics and some physical measures had significant relationships. These relationships may suggest that some spindle characteristics are influenced by the individual development rather than by a genetic trait.

Adolescent↗
PubMed1987

Lennox-gastaut syndrome with and without Dandy-Walker malformation.

The authors present two siblings suffering from Lennox-Gastaut syndrome. One of them also had the Dandy-Walker malformation. His seizures were difficult to control with anticonvulsant drugs, and somnolence and cerebellar ataxia easily occurred during administration of low dose anticonvulsants. On the other hand, his brother did not have this malformation, and his seizures were easily controlled. The relationship of seizure control to the Dandy-Walker malformation is discussed.

Child↗
PubMed1987

Serial polysomnograms in Creutzfeldt-Jakob disease.

This is a report of the case of a patient with Creutzfeldt-Jakob disease, whose electroencephalograms and polysomnograms were repeatedly recorded throughout the course of the illness with details of the alterations of periodic synchronous discharges. In the advanced stage of the disease, the appearance of peculiar paroxysms was noted, predominantly in the early morning. Furthermore, apnea of the central type was observed during the same time period. Discussions were held on the mechanisms inducing the EEG paroxysms and apneas.

Cerebral Cortex↗
PubMed1987

[Sleep spindles and physical parameters].

In 4 identical (Nos. 1-4) and 3 fraternal (Nos. 5-7) male twin pairs (mean age, 16 years), sleep spindles were analysed during sleep. The height, body weight, plantar length and chest circumference were measured, and the correlations between sleep spindles and these physical parameters were examined. The physical parameters showed concordance between identical twin pairs except one pair (No. 4) and one fraternal pair (No. 5) but discordance between two fraternal twin pairs (Nos. 6 and 7). Number of sleep spindles and sleep spindle density showed almost concordance between identical twin pairs and one fraternal pair (No. 5), while discordance between two fraternal ones (Nos. 6 and 7). Both number of sleep spindles and sleep spindle density were inversely correlated with body weight (r = -0.61, p less than 0.02; r = -0.62, p less than 0.02). These facts would suggest that sleep spindles rather reflect the individual development than genetic trait.

Adolescent↗
PubMed1986

Interstitial deletion of the long arm of chromosome 8 without Langer-Giedion syndrome.

A case of interstitial deletion of the long arm of chromosome 8 is reported. A chromosome analysis by a high resolution banding revealed the abnormal karyotype, 46, XY, del (8) (q11.2q13). Although some reports describe an association of 8q deletion with the Langer-Giedion syndrome, this patient did not have the typical features of this syndrome. It was noted that the patient had amino aciduria, EEG and ECG abnormalities together with other pathological findings.

Adolescent↗
PubMed1985

Electroencephalographic findings in neuroacanthocytosis.

This study reports the electroencephalographic findings in two siblings with neuroacanthocytosis. Slowing of the background activity with diffuse slow waves was the main finding in the daytime EEG. All-night polysomnographic recordings were characterized by high voltage slow activity during drowsy state and REM sleep. One patient with an average of 40 episodes of apnea per night of sleep was treated with imipramine and showed respiratory improvement.

Acanthocytes↗