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Biomedical subjects

S Kestenbaum

Publications and source records attributed to S Kestenbaum.

7 recordsLinked to original sources
PubMed1986

Gonadotropin responses to low dose pulsatile administration of GnRH in a case of anosmia with hypogonadotropic hypogonadism associated with gonadal dysgenesis 47 XXY.

A 25 year old man presented hypogonadotropic hypogonadism with complete anosmia (Kallman's syndrome). His chromosomic type was 47 XXY (Klinefelter's syndrome). Clinical findings were: height 183 cm, weight 62 kg, increased length of lower limbs, P2-A2 pilosity and micropenis. Only a left testis was present (1.5-1.5 cm). Bone age was 15. Testicular biopsy showed that the signs were more related to the gonadotropic deficit than to the gonadal dysgenesis; tubular hyalinization was not observed. Plasma levels of testosterone and oestradiol were very low. Plasma gonadotropin levels were below normal ranges and did not respond to an infusion test of GnRH. GnRH was administered iv every 90 min for 3 weeks by an auto syringe infusion pump and induced a pulsatile response of FSH and LH. Plasma levels of testosterone and oestradiol were unaffected. It may be concluded that the results of pulsatile injection of GnRH confirmed in this patient a unique association of Kallmann's syndrome with complete 47 XXY Klinefelter's syndrome.

Adult↗
PubMed1985

[How to define the normal level of serum IgE in adults?].

Variations in the upper limit of normal total serum IgE have been reported: they can range from 150 to 1,000 UI/ml; but the usually accepted upper limit is between 150 and 300 UI/ml. In this study we measured the total serum IgE levels (RIST-Pharmacia) in 69 randomly selected control subjects; 38 had no previous history of atopic or parasitic disease. The normal values observed were 7-460 UI/ml for the whole of the control group (10th-90th percentiles) and 0.5-540 UI/ml for the 38 selected subjects (5th-95th percentiles). Logarithmic conversion is compulsory in order to obtain a gaussian distribution. This enables 80 p. 100 of the control subjects to be grouped within 4-450 UI/ml or 90 p. 100 of the selected subgroup within the range of 1.5-677 UI/ml. As many allergic patients have a normal serum IgE level and a number of non-allergic diseases may be associated with an increased serum IgE level, the diagnostic importance of this investigation is limited. The cost-effectiveness is very low and raises the problem of using this test in everyday practice.

Adult↗
PubMed1984

Decreased plasma epinephrine concentrations after glucose ingestion in humans.

Plasma levels of norepinephrine (NE), epinephrine (E), immunoreactive insulin (IRI), and glucose were measured in six healthy volunteers after glucose consumption and in six volunteers after a water solution. Ingestion of the glucose (100 g) solution significantly decreased E levels from 46.7 +/- 8.0 to 20.8 +/- 1.9 pg/mL (P less than 0.01). Three hours after the glucose ingestion, plasma E levels nearly returned to basal values. Plasma IRI and glucose levels peaked at 45 minutes after glucose consumption (P less than 0.01), then declined toward basal values. Plasma NE levels were unaffected by glucose consumption. There were no changes in glucose, IRI, NE, or E levels in the control group. These results suggest that E behaves as a counter-regulatory hormone to insulin under stimulation by glucose.

Adult↗
PubMed1984

Serum IgE in primary glomerular diseases.

Serum IgE was measured by RIST test in 181 adult subjects, with log transformation. In 24 controls the geometric mean was 109 IU/ml, with an upper limit (geometric mean +/- 2 SD) of 460 IU/ml. 157 cases of glomerulonephritis (GN) classified according to light and immunofluorescence microscopy were studied. Serum IgE was significantly elevated in 39 lipoid nephrosis patients (p less than 0.001, with 21 levels greater than 460 IU/ml), 21 focal and segmental glomerulosclerosis (p less than 0.05, with 8 levels greater than 460 IU/ml) and 42 membranous GN (p less than 0.01, with 10 levels greater than 460 IU/ml). In 27 membrano-proliferative GN and 28 IgA GN, serum IgE was not different from controls with respectively 4 and 3 levels greater than 460 IU/ml. In addition, the lipoid nephrosis IgE geometric mean is 493 IU/ml, which is keeping with the high incidence of atopic troubles. The significance of raised serum IgE was discussed.

Adolescent↗
PubMed1984

[Assay of C-peptide in diabetes in children and adolescents].

Thirty eight children and adolescents aged 3 to 19 years with insulin-dependent diabetes had basal plasma C-peptide levels 50 to 70 p. 100 lower than comparable non-diabetic subjects. An appreciable residual fasting endogenic secretion greater than 1 ng/ml was found in half the patients during the first two years after the onset of diabetes. After this period, the concentrations were almost always lower than 1 ng/ml and in half the cases, at the lower limit of detection. In addition, it was difficult to stimulate C-peptide secretion by food or drugs. The effects of variations in blood glucose were made allowance for by using molar C-peptide/glucose ratio. This gives a better evaluation of the inverse relationship between residual pancreatic function and the duration of the diabetes and of the degree of residual beta-langerhans secretion to help obtain stable metabolic equilibrium.

Adolescent↗