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Biomedical subjects

S Khoór

Publications and source records attributed to S Khoór.

7 recordsLinked to original sources
PubMed1993

[Variability of the circadian heart rate in diabetes mellitus-related autonomic neuropathy].

For assessing the alterations of circadian heart rate variability 66 diabetic patients (age: 52.9 +/- 1.0 years; x +/- SEM) and 23 control subjects (age: 52.7 +/- 1.7 years) were investigated using 24 hours Holter monitoring. Autonomic neuropathy (AN) was evaluated by tests for cardiovascular reflexes and patients were classified as being without AN (n = 26), having mild (n = 25) or definitive (n = 15) signs of AN. Minimal heart rates were significantly higher while maximal heart rates were considerably lower in patients with than without AN (60 +/- 2 min-1 versus 54 +/- 1, min-1, p < 0.05 and 125 +/- 4 min-1 versus 146 +/- 4 min-1, p < 0.01). Diabetic groups were comparable regarding values of averaged heart rates. The difference between the mean waking and sleeping averaged heart rates was the smallest in diabetic patients with definitive signs of AN (9 +/- 2 min-1) differing from those of control subjects (17 +/- 1 min-1, p < 0.01) and diabetic patients without (17 +/- 1 min-1, p < 0.001) or with mild (15 +/- 1 min-1, p < 0.05) signs of AN. Characteristic alteration, i.e. a reduction in circadian heart rate variability could be found in diabetic patients with signs of AN. This phenomenon has primarily been a consequence of more frequent sleeping heart rates due to dominant impairment in cardiac parasympathetic innervation.

Analysis of Variance↗
PubMed1993

[Connection between painless abnormal ST-deflection and autonomic neuropathy in diabetes mellitus].

In order to assess the relationship between abnormal but silent ST-segment depression and autonomic neuropathy 63 diabetic patients (age: 40-71 years, duration of diabetes: 2-32 years) without a history of angina pectoris were investigated. Transient ST-segment depression was assessed by 24 hours Holter monitoring and, in addition, dynamic exercise on bicycle ergometer was also performed in all but 7 patients. Autonomic neuropathy was evaluated by cardiovascular function tests (deep breathing, Valsalva manoeuvre and lying-to-standing). Abnormal ( > or = 2 mm) ST segment depression was observed in 11 patients (18%) while signs of autonomic neuropathy were found in 37 diabetics (59%). Signs of autonomic neuropathy were significantly (p < 0.01) more often documented in patients with (11/11) than without (26/52) abnormal ST-segment depression. It was concluded that autonomic neuropathy could be a possible explanation for lacking symptoms from abnormal ST-segment depression in diabetic patients.

Adult↗
PubMed1990

Left ventricular diastolic dysfunction in type 1 (insulin-dependent) diabetic patients during dynamic exercise.

The left ventricular diastolic and systolic functions were assessed in 27 strictly selected type 1 diabetic patients without overt heart disease and 50 age- and sex-matched control subjects. For evaluating left ventricular performance, complex mechanocardiography including digitized apexcardiography was used at rest and after symptom-limited, graded dynamic exercise. The values of diastolic/systolic time intervals and amplitude parameters did not differ significantly between the diabetic and control groups at rest. A longer value of corrected early apexcardiographic relaxation time (diabetics: 38.7 +/- 2.6 ms, controls: 17.3 +/- 2.1 ms, p less than 0.001) and a smaller normalized amplitude of relaxation (diabetics: 0.014 +/- 0.004 ms-1, controls: 0.056 +/- 0.006 ms-1, p less than 0.001) were observed after dynamic exercise suggesting disturbances of the early diastole in diabetic patients. No correlations could be found between the diastolic abnormalities and the diabetic control. Significant correlation was observed between the diastolic disorders and the duration of diabetes mellitus. Testing left ventricular performance by complex mechanocardiography including digitized apexcardiography after dynamic exercise in patients with type 1 diabetes might be useful for recognizing diastolic abnormalities even when no alterations could be identified at rest. Diastolic disorders could appear in diabetic patients without overt heart disease and clinical symptoms. Left ventricular systolic function might be normal, although exercise-induced alterations of diastolic function might already be present in type 1 diabetic patients.

Adolescent↗