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S Kingsley

Publications and source records attributed to S Kingsley.

At least 19 recordsLinked to original sources
PubMed2001

Tethered pyrazolyl phosphinate: pyrazolyl-N- and phosphoryl-O-metal coordination in Ph(2)P(O)[OCH(2)CH(2)(3,5-Me(2)Pz)].

Phosphorus pyrazolides, P(O)(3,5-Me(2)Pz)(3) or RP(E)(3,5-Me(2)Pz)(2) [E = S or O, R = Me or Ph], are hydrolytically sensitive particularly upon interaction with transition metal ions. In this paper, we report a new tethered pyrazolyl phosphinate, Ph(2)P(O)[OCH(2)CH(2)(3,5-Me(2)Pz)] DPEP (1), where the pyrazolyl group is separated from the phosphorus by means of an ethyleneoxy spacer. 1 has two potential coordination sites in the form of a phosphoryl oxygen atom and a pyrazolyl nitrogen atom. 1 forms hydrolytically stable complexes, (DPEP-CoCl(2))(n)(2), (DPEP)(2)-CuCl(2) (3), (DPEP-ZnCl(2))(n )(4), and (DPEP)(2)-PdCl(2) (5). The cobalt(II) and the zinc(II) complexes 2 and 4 show a zigzag polymeric structure in the solid state with a tetrahedral coordination geometry around the metal ion; the ligand DPEP coordinates through its phosphoryl oxygen and the pyrazolyl nitrogen to two neighboring metal ions and functions as a bridging ligand to form the polymeric structure. In contrast to 2 and 4, the copper(II) and the palladium(II) complexes 3 and 5 show a square-planar geometry around the metal ion. Exclusive coordination through the pyrazolyl nitrogens of the ligand 1 is observed. An extensive supramolecular sheetlike two-dimensional polymeric network is observed in the solid-state structures of 3 and 5 as a result of two weak interactions: (a) an intermolecular C-H- - -O interaction involving the phosphoryl oxygen and an aromatic C-H and (b) a pi-pi face-to-face stacking interaction between the phenyl groups of two adjacent molecules.

Journal Article↗
PubMed2000

Formation of a tetranuclear copper (II) cluster assembled by metal-assisted hydrolysis and desulfurization of bis(3,5-dimethylpyrazolyl)methylphosphine sulfide, MeP(S)(3,5-Me2Pz)2.

The reaction of methylphosphine sulfide, MeP(S)(3,5-Me2Pz)2, 1, with anhydrous CuCl2 affords a tetranuclear copper cluster[Cu2Cl2(3,5-Me2Pz)3(MePO3)]2, 2, and a dinuclear compound Cu2Cl4(3,5-Me2Pz)4, 3. This reaction involves a metal-assisted desulfurization along with concomitant hydrolysis of P-N bonds. The X-ray structures of 1-3 have been determined, and the crystal parameters for these are the following. 1: space group = C2/c, a = 15.2552(1) A, b = 8.7364(2) A, c = 21.4490(3) A, beta = 93.349(1) degrees, V = 2853.74(8) A3, and Z = 8. 2: space group = P2(1)/n, a = 12.5964(4) A, b = 15.7773(4) A, c = 13.9781(4) A, beta = 116.6280(10) degrees, V = 2483.32(12) A3, and Z = 2. 3: space group = P2(1)/c, a = 8.7137(8) A, b = 13.5493(14) A, c = 11.8847(12) A, beta = 106.179(2) degrees, V = 1347.6(2) A3, and Z = 2. The structure of 2 shows that it comprises two dinuclear copper cores bridged together by two tripodal methylphosphinate, MePO3, ligands. 2 is weakly antiferromagnetically coupled, as revealed by variable temperature magnetic susceptibility measurements.

Journal Article↗
PubMed2000

A Dodecanuclear Copper(II) Cage Containing Phosphonate and Pyrazole Ligands This work was supported by a grant from the Department of Science and Technology (DST), New Delhi (V.C.). V.C. is also grateful to the Homi Bhabha Fellowship Council for a fellowship. We thank the DST for funding the National Facility for X-ray Crystallography at the Indian Institute of Technology, Kanpur. We thank Prof. Dr. P. K. Bharadwaj for his help in the data collection and X-ray analysis, and Prof. Dr. A. R. Chakravorthy, Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, India for the magnetic measurements on 1.

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Journal Article↗
PubMed1996

Management of leprosy on the basis of the epidemiology of disabilities.

With the reduction on caseload due to the impact of multidrug therapy (MDT) in most parts of India, we believe that there is a need to understand the epidemiology of disabilities in leprosy which may not necessarily correlate with the distribution pattern of active disease. We present a methodology of data collection and verification taking the district as a unit to calculate the prevalence rate of disability as an exclusive entity in the district population, unrelated to the problems posed by the communicable component of leprosy. This study indicated that the prevalence rate of Grade II disabilities in 14 hyperendemic districts was 0.82/1000, whereas it was 0.22/1000 in low endemic districts. Limb disability data collected from three hyperendemic districts in Andhra Pradesh following task-oriented training enabled the paramedical worker to offer services to 5753 disabled patients after assessing the disability caseload per worker.

Persons with Disabilities↗
PubMed1984

Detection of gastrointestinal bleeding by radionuclide scintigraphy.

Scanning with Technetium 99m labeled autologous red blood cells was performed in 59 patients with clinical suspicion of acute and/or intermittent, chronic gastrointestinal bleeding. In 36 patients (61%), a definite site of bleeding could be demonstrated. A strong correlation with other modalities such as upper and lower gastrointestinal endoscopy, contrast angiography, and surgical exploration was found. Overall sensitivity of the procedure was 91%; specificity 100% and accuracy 93.3%. It is suggested that radionuclide scintigraphy provides a completely noninvasive, simple, and sensitive procedure which may be routinely used for the detection and localization of gastrointestinal bleeding.

Adult↗
PubMed1979

Glycohemoglobin and glucose tolerance tests compared as indicators of borderline diabetes.

We concurrently measured glycohemoglobin and performed 3-h oral (100 g) glucose tolerance tests on 69 ambulatory patients suspected of having abnormal carbohydrate metabolism. The patients were divided into two groups: (a) The 37 patients for whom the results were normal had plasma glucose concentrations of 0.70--1.15 milligram during fasting and 0.70--1.23 g/L 2 h after glucose ingestion. (b) Borderline diabetics exceeded one or both of these limits. The range of glycohemoglobin in the normal group was 3.0--4.7% of total hemoglobin. Of the 21 borderline diabetics, 11 had increased glycohemoglobin (4.8--8.0%). The difference in tolerance test results between borderline diabetics with and without increased glycohemoglobin was insufficient to predict the status of glycohemoglobin. We suggest a tentative definition for latent diabetes: increased glycohemoglobin in the presence of normal or borderline-abnormal glucose concentration in plasma collected during fasting.

Adolescent↗