S Kirazli — Page 6 | PubMed Health

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Plasma thrombomodulin levels in early respiratory distress syndrome.

Infants with respiratory distress syndrome (RDS) undergo hemodynamic alterations in both the pulmonary and systemic vascular beds that predispose these infants to microvascular damage. In addition, disseminated intravascular coagulation (DIC) is frequently encountered in preterm infants with advanced RDS. In preterm infants with RDS, the plasma status is not known. Therefore, we studied plasma thrombomodulin levels in 25 preterm infants who did or did not develop RDS within the first few hours of life. The mean plasma thrombomodulin levels were found to be similar in the two groups (8.12 +/- 10.20 ng/ml vs. 18.30 +/- 22.77 ng/ml, respectively, p > 0.05 by Mann-Whitney U Test). It seems that plasma thrombomodulin levels are normal in the earlier stages of RDS before the occurrence of severe vascular damage and DIC due to hypoxemia.

Birth Weight↗

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Effects of colchicine on inflammatory cytokines and selectins in familial Mediterranean fever.

OBJECTIVE: To evaluate whether basal levels of circulating cytokines and selectins exhibit a distinct profile in attack-free, non-colchicine taking familial Mediterranean fever (FMF) patients compared to normal healthy controls, and to determine the effect of colchicine treatment on these parameters. METHODS: Serum levels of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, and soluble P-, E-, and L-selectin in attack-free, asymptomatic, non-colchicine using FMF patients (n = 11) and in normal controls (n = 10) were studied. Following 2 months of colchicine treatment the same parameters were evaluated again in the FMF patients. RESULTS: Before colchicine treatment the serum levels of all parameters except soluble P-selectin were significantly higher in FMF patients than in controls. After two months of treatment statistically significant decreases were observed in these parameters (p < 0.05). CONCLUSION: A distinct profile of IL-6, IL-8, TNF-alpha, and soluble E- and L-selectin levels was observed in FMF patients, which could reflect the presence of sustained inflammation in attack-free FMF patients. The effect of colchicine on these parameters suggests its therapeutic potential.

Adult↗