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S Kline

Publications and source records attributed to S Kline.

10 recordsLinked to original sources
PubMed1991

Serum CD4, CD8, and interleukin-2 receptor levels in childhood acute myeloid leukemia.

Leukemic cell expression and serum levels of CD4, CD8, and interleukin-2 receptor (IL-2R) were determined at diagnosis for children or adolescents with acute myeloid leukemia (AML). Cellular expression of CD4 was detected in 18 of 62 cases, CD8 in none of 60 cases, and IL-2R in one of 33 cases tested. Myeloblasts of the M4 and M5 subtypes expressed CD4 significantly more frequently than other FAB subtypes (p = 0.0001). Serum levels of the three soluble factors (tested for 91 patients) were positively correlated with each other. Increased serum CD4 levels were significantly associated with cellular CD4 expression, high leukocyte count, M5 leukemia, spleen enlargement, and age less than 1 year. High serum CD8 levels correlated significantly with splenomegaly, extramedullary disease, absence of Auer rods, and high leukocyte count. Cases with high serum IL-2R levels were less likely to have Auer rods and more likely to have splenomegaly and M5 leukemia; serum levels greater than 750 U/ml were associated with a higher probability of treatment failure (p = 0.05), even after adjustment for other potential prognostic factors. Further studies of serum CD4, CD8, and IL-2R levels may help to clarify the immunoregulatory role of T-cells in patients with AML.

Antigens, Differentiation, T-Lymphocyte↗
PubMed1989

Reactivation of Toxoplasma gondii by cytomegalovirus disease in mice: antimicrobial activities of macrophages.

Reactivation of Toxoplasma gondii infection often occurs concurrently with active cytomegalovirus (CMV) disease in immunocompromised patients, and CMV disease results in immunosuppression. To determine if murine CMV (MCMV) infection decreases resistance to T. gondii, mice with latent T. gondii infection were infected with MCMV. T. gondii infection reactivated, manifested primarily as pneumonia. Lung macrophages supported the growth of T. gondii before, during, and after T. gondii reactivation. Peritoneal macrophages inhibited the growth of T. gondii as pneumonia developed and became permissive as pneumonia resolved. Mice with latent T. gondii infection could survive larger doses of MCMV than could controls. Thus, MCMV infection led to reactivation of latent T. gondii infection in mice. Activation of lung macrophages, assessed by their ability to inhibit replication of T. gondii in vitro, was not associated with control of T. gondii infection.

Animals↗
PubMed1987

Group A beta-hemolytic streptococcal skin infections in a US meat-packing plant.

In 1985, the second reported outbreak of group A beta-hemolytic streptococcal (GABHS) skin infections among US meat packers was recognized at an Oregon meat-packing plant. All 69 plant workers were interviewed and examined for the presence of pustular, draining, or inflamed lesions. During a three-month period, 44 episodes of skin infection occurred in 32 workers, all but four of whom worked in boning or killing areas. Acquiring infection was associated with job category (relative risk [RR], 5.7; 95% confidence intervals [CI], 2.9 to 11.3) and having at least two hand lacerations (RR adjusted for occupation, 6.2; 95% CI, 3.0 to 12.5). Group A beta-hemolytic Streptococcus (18), Staphylococcus aureus (12), or both (20) were isolated from 70 lesions cultured. Meat is suspected as a vehicle of transmission because cultures of two meat specimens contained the same GABHS strain as did 24 isolates from patients. Increasing reports of GABHS skin infections in meat packers suggest that this occupational risk may be more common than is realized.

Abattoirs↗
PubMed1985

Ventral tegmental area of the rabbit brain: a developmental Golgi study.

The ventral tegmental area (VTA) of the rabbit mesencephalon was examined with Golgi-Cox impregnation at neonatal (days 3-21 of age) and young adult (6-12 months of age) stages of development. Neurons in the dorsal midline were small, with sparsely-branched, vertically-oriented dendrites. Neurons in the ventral midline were medium-sized, oval cells with sparse, vertically-oriented dendrites, and multipolar cells with more abundant diffusely-oriented dendrites. Neurons in the medial zone of the VTA, between the midline and the exiting III nerve fibers, were oval in shape, medium in size, and possessed vertical dendritic arborizations of greater size and extent of branching than those in the dorsal midline. Lateral neurons, found among III nerve fibers, were medium-sized and possessed dendritic trees that were specifically oriented in a vertical or horizontal plane, or were diffusely-branched with more abundant arborizations than their specifically oriented counterpart. Very small neurons with short, single branches were scattered among all regions of the VTA. The major cell types showed a similar pattern of dendritic maturation. At 3-9 days of age, the dendrites were generally short, spiny and poorly branched. From days 9-21, the branches increased in number and length, spines were lost, and these neurons rapidly approached adult size and form. The neurons of VTA appear isodendritic in form, and developed in a pattern consistent with other areas of reticular formation, suggesting that VTA may be part of the reticular core of the brain stem.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1978

I. Formulation.

The authors describe a systematic approach to the process of formulation. Four interlocking phases are considered. The longitudinal data collection evaluate the patient's developmental journey. The cross-sectional evaluation includes careful consideration of phenomenological and dynamic factors. The integrative evaluation of these factors permits the construction of both a dynamic and a phenomenological diagnosis. Finally, in hypothesizing a tentative prognosis, we attemt to predict the capacity and quality of a person's potential change and readjustment.

Adolescent↗
PubMed1978

II. A method of reporting formulation.

The authors present a method of reporting and evaluating a formulation. The reporting of a formulation includes a summary introduction, biological considerations, psychosocial considerations and hypothesis construction. Three sample formulations are scrutinized and specific critical evaluations offered. The subsequent reformulations are presented.

Adult↗