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Biomedical subjects

S Knezevich

Publications and source records attributed to S Knezevich.

7 recordsLinked to original sources
PubMed2005

Concurrent translocation of BCL2 and MYC with a single immunoglobulin locus in high-grade B-cell lymphomas.

B-cell leukaemia or lymphoma with a combination of t(8;14)(q24;q32) of Burkitt leukaemia/lymphoma and t(14;18)(q32;q21) of follicular lymphoma may present clinically as de novo acute lymphoblastic leukaemia or transformation of follicular lymphoma to aggressive histology diffuse lymphoma. A number of cell lines have been reported with a complex t(8;14;18) with fusion of MYC, IGH and BCL2 on the same derivative 8 chromosome. The objective of this study was to determine the frequency and chromosomal features of this der(8)t(8;14;18) in a series of acute leukaemias and malignant lymphomas. A database of 1350 leukaemia and lymphoma karyotypes was searched for cases with structural alterations affecting both 8q24 and 18q21. A total of 55 cases were identified, of which eight revealed a complex der(8)t(8;14;18) with an MYC-IGH-BCL2 rearrangement resulting from translocation of BCL2 and MYC with a single disrupted IGH allele. Molecular cytogenetic investigation is essential to identify cases of high-grade leukaemia/lymphoma with concurrent translocations affecting the BCL2 and MYC loci.

Adult↗
PubMed1993

N-methyl-D-aspartate-induced nitric oxide release: an in vivo microdialysis study.

Increasing evidence indicates that nitric oxide acts as an intercellular signal transduction molecule in the nervous system. In particular, in vitro studies have demonstrated that nitric oxide is produced in the cerebellar cortex and is responsible for the increases in cyclic GMP seen in response to glutamate receptor activation. In this study, we have combined the technique of intracerebellar microdialysis with a sensitive assay for nitric oxide oxidation products nitrate and nitrite, to assess nitric oxide release directly in awake, freely moving animals. We have found that infusion of N-methyl-D-aspartate via the microdialysis probe results in a dose-dependent increase in cerebellar nitric oxide release. This increase was prevented by prior administration of an N-methyl-D-aspartate receptor antagonist, or the nitric oxide synthase inhibitor NG-nitroarginine. Both these pretreatments also reduced the basal extracellular nitrite and nitrate levels, suggesting that there is a tonic glutamate-induced nitric oxide production in the cerebellum of awake, freely moving animals. These results provide direct evidence for nitric oxide release in response to N-methyl-D-aspartate receptor activation in the adult cerebellar cortex, in vivo. This new approach, coupling microdialysis with the azo dye detection method of Griess, should thus prove useful for the in vivo study of nitric oxide release from various brain regions in response to pharmacological, physiological or behavioral manipulations.

Amino Acid Oxidoreductases↗
PubMed1990

Symptomatic scapholunatotriquetral carpal coalition with fusion of the capitatometacarpal joint. Report of a case.

Carpal coalition is not an uncommon entity. It is most often asymptomatic and coincidentally noted on roentgenograms. The most common location is between the lunate and the triquetrum, although nearly every combination has been reported. Reported is a 33-year-old man with a symptomatic scapholunatotriquetral carpal coalition associated with capitatometacarpal coalition. This condition seems not to have been previously reported in the literature.

Adult↗
PubMed1990

Streptococcal toxic shocklike syndrome leading to bilateral lower extremity compartment syndrome and renal failure. Report of a case.

Compartment syndrome is considered a true emergency in orthopedic practice. To reduce morbidity and mortality from this condition, prompt diagnosis and appropriate treatment are absolutely essential. An unusual bilateral lower extremity compartment syndrome leading to renal failure and crush syndrome occurred in a 13-year-old girl with Streptococcal toxic shocklike syndrome. This situation seems not to have been previously reported. Early diagnosis and expeditious treatment produced minimal sequelae of the condition.

Acute Kidney Injury↗
PubMed1989

Use of the Greenfield filter to prevent fatal pulmonary embolism associated with total hip and knee arthroplasty.

We inserted a Greenfield filter prophylactically in forty-two of approximately 4,000 patients who were about to have a total hip or knee replacement, or both, and who were at high risk for pulmonary embolism (Group I). The filter was implanted postoperatively in twenty-four additional patients who had thromboembolic complications or in whom anticoagulation was contraindicated (Group II). None of the patients in Group I and only one in Group II had a fatal pulmonary embolism. Use of the Greenfield filter is a safe, easy, and effective method of preventing fatal pulmonary embolism in selected patients: those who are at exceptionally high risk for thromboembolism, as a method of preoperative prophylaxis; those who have had a thromboembolism and in whom therapeutic anticoagulation is contraindicated; and those who have complications secondary to therapeutic anticoagulation.

Adult↗
PubMed1989

Total joint replacement: both a miracle and a disappointment.

Total joint arthroplasty has become a successful therapy for patients with debilitating arthritis of the major weight-bearing joints. However, by current standards, the life of a total joint implant is approximately 10 to 15 years. Older, more sedentary patients enjoy greater and longer-term success than younger, active patients. Eventually, most implants fail because of component loosening. Currently, efforts to obtain longer-term implant stability are focused on achieving bone growth into the implanted components. A new process of plasma-spraying hydroxyapatite--an entirely biocompatible, bioceramic material--onto porous, titanium alloy components promotes bone ingrowth into the components resulting in implant fixation, which is superior to current methods of cemented or cementless fixation. Early results suggest that hydroxyapatite-bioingrowth fixation may be the start of a new era in joint implant surgery.

Arthritis↗