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Biomedical subjects

S Kohata

Publications and source records attributed to S Kohata.

8 recordsLinked to original sources
PubMed2005

[The relationship between supraventricular arrhythmia after coronary artery bypass grafting and autonomic nerve system].

We evaluated the relationship between supraventricular arrhythmia after coronary artery bypass grafting (CABG) and autonomic nerve system. Holter electrocardiogram was recorded in 57 postoperative patients. The heart rate variability was analyzed in 25 premature atrial contraction (PAC) cases and 4 atrial fibrillation (AF) cases. Sixty minutes just before the onset of PAC/AF were devided into 12 equal parts, and NN 50, RMSSD, HF, LF/HF were measured respectively. NN 50, RMSSD and HF were each used as an indicator to show the parasympathetic nerve (PSN) activity, and LF/HF as an indicator to show the sympathetic nerve (SN) activity. The mean value of the former 6 parts was compared to that of the latter 6 parts. As for 25 PAC cases, PAC occurred under the dominance of PSN in 30% of the cases, under the dominance of SN in 10% of the cases and under the balanced condition of both nerves in 60% of the cases. As for 4 AF cases, AF occurred under the parasympathetic condition in 3 cases and under the sympathetic condition in 1 case. These results show that supraventricular arrhythmia after CABG is associated with PSN system.

Atrial Fibrillation↗
PubMed2001

[Evaluation of off-pump coronary artery bypass grafting based on systemic inflammatory response syndrome].

Assessment of the less-invasiveness of off-pump coronary artery bypass grafting (OP-CAB) was made by the view point of systemic inflammatory response syndrome (SIRS). Single vessel OP-CAB with median sternotomy (MS(+)OP-CAB group, n = 13), single vessel OP-CAB without median sternotomy (MS(-)OP-CAB group, n = 9), two vessels conventional coronary artery bypass grafting (C-CAB) by normothermic extra corporeal circulation with steroid (methylprednisolone) (s(+)C-CAB group, n = 13), and two vessels C-CAB without steroid (s(-)C-CAB group, n = 13) were compared with each other. The criteria for SIRS was two or more of the following conditions: (1) temperature > 38.0 degrees C, (2) respiratory rate > 20 breaths/min, (3) heart rate > 90 beats/min, (4) white blood cells > 12,000 cells/mm3. Patients' date such as age, sex, risk factors, ejection fraction, operation time, aortic or LAD clamping time, frequency of SIRS, duration of SIRS, total application number of SIRS, mean application number of SIRS, hospitalization period, rate of renal or liver dysfunction were compared, and the following results were obtained. 1) MS(+)OP-CAB group had less-invasiveness than s(-)C-CAB group. The invasiveness of extra corporeal circulation was clear. 2) s(+)C-CAB group had equal invasiveness to MS(+)OP-CAB group. The anti-SIRS effect and organ protect effect of steroid was suggested. 3) MS(-)OP-CAB group had equal invasiveness to MS(+)OP-CAB group. The invasiveness of median full sternotomy was not so strong.

Aged↗
PubMed1999

The interaction between human and bovine serum albumin and zinc studied by a competitive spectrophotometry.

The binding of zinc to human serum albumin (HSA) and bovine serum albumin (BSA) has been studied by a competitive spectrophotometry. The indictor ligand, 5-Br-PAPS, as well as its metal complexes, ML and ML2, having intense colors with sufficient separate absorption peaks permits the analysis of the interaction between zinc and HSA or BSA. The results show that zinc binds to both albumins in the molar ratio of 1:1 at pH 6-8. The apparent association constants of Zn-HSA and Zn-BSA decrease with decreasing pH. The pH dependence of the constants for both Zn-HSA and Zn-BSA indicates the 1:1 competition between metal ions and hydrogen ions for the binding site. The intrinsic association constants of the metal and the proton are found to be log KZn-HSA = 7.1 +/- 0.2 and log KH-HSA = 8.2 +/- 0.3 for HSA and log KZn-BSA = 7.6 +/- 0.2 and log KH-BSA = 8.2 +/- 0.3 for BSA, respectively.

Animals↗
PubMed1998

[Acute aortic dissection after aortic valve replacement].

A 53-year-old male who had been performed aortic valve replacement 15 weeks before was admitted to our hospital because of severe chest pain. Cjest computerized tomography showed dissection of aorta from ascending to descendig aorta and hemorrhage around ascending aorta. An emergency operation was performed under hypothermic circulatory arrest with a selective cerebral perfusion. An entry of dissection was found at posterior wall where was 3 cm upper from an artificial valve. Total arch replacement was successfully performed. There is a few cases of aortic dissection after aortic valve replacement, but careful peri and post operative care is necessary after aortic valve replacement.

Acute Disease↗
PubMed1997

Effects of acute arterial bleeding on renal sympathetic nerve activity in young and old anesthetized rats.

We compared the change in renal sympathetic nerve activity (RNA) during hemorrhage in young and old rats. Young (10 weeks) and old (80 weeks) male Wistar rats were anesthetized, and RNA together with arterial pressure (AP) and heart rate (HR) were measured under spontaneous respiration. Acute arterial bleeding, 1ml/100g body weight, was carried out to induce hypotension and hypovolemia. With bleeding, mean AP (MAP) decreased from 110 +/- 12 to 23 +/- 11mmHg (mean +/- SEM) and from 93 +/- 15 to 15 +/- 6mmHg in young and old rats, respectively. The difference in the change of MAP between the young and old rats was not significant. With bleeding, mean RNA increased by 46 +/- 21% and 20 +/- 16% in young and old rats, respectively. The increase in mean RNA of the old rats was significantly lower than that of the young rats. We estimated the gain of the baroceptor-renal sympathetic nervous system by using the formula delta RNA/RNA/delta MAP/MAP. The gain was 0.61 +/- 0.34 and 0.23 +/- 0.18 in young and old rats, respectively. The difference in the gain was statistically significant (p < 0.05). We concluded that the gain of baroceptor-sympathetic nerve system in acute arterial hemorrhage is attenuated with aging.

Aging↗
PubMed1993

The binding of Yb(III) and Gd(III) to bovin serum albumin by a competitive spectrophotometry.

A competitive spectrophotometry has been used to study the binding of Yb(III) and Gd(III) to BSA. The indicator ligand, 5-Br-PAPS, as well as its metal complexes, ML, having intense colors with sufficiently separate absorption peaks permits the analysis of the interaction between metal and BSA. Experimental data are analyzed by using Scatchard plots. The results show that both Yb and Gd bind to BSA with four equivalent affinity sites at pH 6-7. Some additional lower affinity sites are observed for Gd but not for Yb. The slope of the plots, the apparent association constant of the metal with BSA, decreases with decreasing pH. The pH dependence of the apparent association constant indicates the 1:1 competition between metal ions and hydrogen ions for the binding site. The intrinsic association constant of the metal, KM(H-1A), and the proton association constant, KH(H-1A) =, are found to be logKM(H-1A) = 7.00 +/- 0.03 and log KH(H-1A) = 7.08 +/- 0.06 for the Yb binding sites, and logKM (H-1A) = 6.16 +/- 0.08 and log KH(H-1A) = 6.63 +/- 0.10 for the Gd binding sites by a graphical analysis (A = BSA).

Binding Sites↗
PubMed1993

[Surgical treatment of aortic valve regurgitation associated with Behçet's disease].

We experienced a patient of aortic valve regurgitation associated with Behçet's disease. The patient underwent aortic valve replacement. There are 15 cases of valvular heart disease associated with Behçet's disease including this reported case. Patients often have perivalvular leakage after valve replacement because not only the aortic but also the surrounding aortic walls become inflamed from the effects of Behçet's disease. We treated our patient to prevent complication. The aortic valve was fixed from the outside of a 2/3 round aortic wall using a teflon strip. The operation was performed when the inflammatory signs and findings subsided, and an adrenal steroid was used after the operation. Satisfactory results were obtained, but since Behçet's disease is systemic progressive and chronic disease, strict observation of the patients and systemic controls of inflammation should be recommended continuously.

Aortic Valve Insufficiency↗