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Biomedical subjects

S Koloszár

Publications and source records attributed to S Koloszár.

At least 19 recordsLinked to original sources
PubMed2005

Is semen quality affected by male body fat distribution?

The aim of this study was to examine the relationship of semen parameters, sexual function-related hormones and waist/hip ratio. Eighty-one selected patients presenting with infertility were examined. Weight, height, waist circumference and hip circumference were measured, and reproduction-related hormone levels were determined. Semen was analysed by conventional methods. Semen volume, sperm concentration, motility, total sperm count, total motile sperm cell number, rapid progressive motile sperm count and reproduction-related hormone levels [follicle-stimulating hormone, luteinizing hormone, prolactin, testosterone, 17beta-oestradiol and sexual hormone-binding globulin (SHBG)]. Significant correlations were found: (i) weight, waist circumference and hip circumference versus testosterone level, SHBG level, and testosterone/17beta-oestradiol ratio; (ii) hip circumference versus sperm concentration; (iii) waist circumference and hip circumference versus sperm count, total motile sperm cell number and rapid progressive motile sperm count; (iv) weight versus total sperm count and total motile sperm cell number; (v) waist circumference and hip circumference versus prolactin level (positively) and SHBG (negatively); (vi) waist circumference and waist/hip ratio versus semen volume. It can be concluded that the waist/hip ratio is correlated with the reproductive hormone levels. Although both the waist circumference and hip circumference correlated with the semen characteristics, the waist/hip ratio did not.

Adult↗
PubMed2004

Low-dose ovulation induction with urinary gonadotropins or recombinant follicle stimulating hormone in patients with polycystic ovary syndrome.

Patients with polycystic ovary syndrome (PCOS) are highly sensitive to gonadotropins. In recent years a number of publications have shown that chronic low-dose protocols are effective in reducing complications, in particular ovarian hyperstimulation syndrome (OHSS), especially if recombinant human follicle stimulating hormone (rhFSH) is used. The aim of the present study was to compare the efficacy and safety of rhFSH (Gonal-F, Serono) versus urinary human FSH (uhFSH) (Metrodin, Serono) in a low-dose step-up protocol for ovulation induction in clomiphene-resistent infertile PCOS patients. Twenty PCOS patients were recruited in two centers for an open randomized comparative study. A starting dose of a 75-IU ampule of rhFSH or uhFSH was used for 14 days with an increment of 37.5 IU every 7 days. Human chorionic gonadotropin (hCG) (10,000 IU, Profasi, Serono) was administered if one to three follicles achieved a diameter of > or = 16 mm. Sonographic and hormonal (serum estradiol and progesterone) monitoring of the cycles was performed. All the six pregnancies induced were in the rhFSH group, but two of them ended with miscarriage. There were no differences between the two groups concerning the number of ampules used, the stimulation days, the estradiol levels on the day of hCG administration, and the progesterone levels 7 days after hCG administration. Three patients had grade II, and one patient grade III OHSS. In conclusion, our results support the literature data that rhFSH is superior to uhFSH regarding pregnancy rates, not only in in vitro fertilization cycles, but also with a low-dose protocol in patients with PCOS.

Drug Administration Schedule↗
PubMed2000

[Treatment of hyperprolactinemic anovulation with the dopamin-agonist quinagolide].

Quinagolide has a strong dopaminerg activity, suppresses prolactin secretion and restores gonadal function in women with hyperprolactinemic anovulation. The aim of our study was to investigate the effectiveness of quinagolide in the treatment of 16 hyperprolactinemic patients. The clinical diagnosis was functional hyperprolactinemia in 13 patients, microprolactinoma in 2 and empty sella syndrome in 1. The drug was administered orally and initially daily dose was 0.025 mg for the first three days, 0.050 mg for the next three days and 0.075 mg for the following 6 months. The serum prolactin level was measured monthly before pregnancy, three monthly during the pregnancy and six weeks after delivery. Serum prolactin levels decreased in most of the patients during the first month and only in one case remained in the pathological range after six months quinagolide++ treatment. Prolactin secretion changed (mean and range) from 3120 (780-5790) mU/l to 370 (84-1076) mU/l. Out of 16 hyperprolactinemic patients nine women were infertile. During quinagolide treatment 5 pregnancies occurred. In conclusion, our results show that quinagolide has a good efficacy on regulation of prolactin secretion and it is a well tolerated dopamin-agonist drug.

Adult↗
PubMed1997

[The value of plasma prolactin level determination in the diagnosis of postmenopausal osteoporosis].

Anovulation condition (estrogen deficiency due to high prolactin level) is linked with premature loss of bone mass. Bone mineral density was measured in the femur neck and the lumbar spine (L2-L4) with DEXA and the bone density was given by Z-score, which makes comparison to adult women's bone mass (normal reference). The examinations were carried out in two different groups. Bone mineral density was measured in the first group in 14 cases with hyperprolactinemic anovulation (aged 28 to 36 years). The average value of Z-score was -1.148 +/- 0.68. In the second group 39 patients (51.9 +/- 2.3 years) took part in the investigation within one year after menopause and the measured Z-score was less than -1.0 (-1.98 +/- 0.4). In the control group there were 40 postmenopausal patients (52.2 +/- 2.4 years) and their Z-score was more than -1.0 (-0.21 +/- 0.14). Prolactin value was 416 +/- 98 mU/l in the investigated group, while in the control group it was 238 +/- 76 mU/l (p < or = 0.05). Our results suggest that continuation of the antiprolactinemic (bromocryptine) treatment following completion of child-bearing appears to be indicated in premenopausal women with increased levels of serum prolactin. During the perimenopause endangered group, whose risk is increasing for postmenopausal osteoporosis, can be stated by determining prolactin level.

Adult↗
PubMed1996

[Ovulation induction with adjuvant antiandrogen treatment in Stein-Leventhal syndrome].

Ovulation induction with adjuvant antiandrogen treatment was carried out in 50 cycles of 24 hyperandrogenic anovulatory patients. Besides the clomiphene and gonadotrophin (pure FSH) administration on the bases of antiandrogenic effects of the drugs three treatment groups (dexamethasone, sprinolactone and cyproterone acetate) were established. In 40 cases of 50 cycles ovulation were detected and 11 pregnancies occurred. The authors achieved the highest ovulation and pregnancy rate in the group treated with cyproterone acetate. The highest progesterone and the lowest testosterone levels were measured in the same group. According to our investigations adjuvant antiandrogen treatment with cyproterone acetate advisable in the cases of hyperandrongenic conditions.

Adult↗
PubMed1995

[Treatment of climacteric urogenital disorders with an estriol-containing ointment].

Estriol containing cream for treatment of climacteric urogenital complaints was used. After 4 weeks local treatment with Ovestin cream atrophy of vaginal epithelium and chronic vaginitis stopped or significantly decreased. During the treatment the ratio of superficial and intermedier cells in the vaginal epithelium increased and the vagina showed a decrease of pH. The subjective complaints relating to the estrogen deficiency (vaginal burning and dryness, itching, dyspareunia and urinary dysfunctions) ceased. Side-effects and complications during the treatment were not found. The cream can easily be used and it is well tolerated. Estriol containing cream is suitable for the treatment of chronic vaginitis and cystitis developed on the base of climacteric epithelium atrophy of urogenital system. Its introduction to the local therapy is necessary because the majority of population of women are interested in it.

Administration, Topical↗
PubMed1993

[Pulsatile gonadotropin releasing hormone treatment following previous ovarian hyperstimulation].

Physiological follicular maturation was achieved by pulsatile gonadotrophin releasing hormone treatment in ovarian hyperstimulatory cases induced previously by other ovulation induction methods (clomiphene, clomiphene + hCG, clomiphene + hMG + hCG). The follicular development was detected by vaginal ultrasound examination (Hitachi-3000, 6.5 MHz) in 8 cycles treated with gonadotrophin releasing hormone. During the pulsatile gonadotrophin releasing hormone treatment ovulation was found in all cases and 2 pregnancies occurred. Ovarian hyperstimulation was not noticed. Physiological follicular maturation can be induced with the pulsatile administration of gonadotrophin releasing hormone after previous ovarian hyperstimulation because using this method the hypophyseal-ovarian steroid feed back mechanism remains unchanged.

Adult↗
PubMed1992

[Changes in melatonin blood levels during gonadotropin releasing hormone loading tests in women with anovulatory disorders].

The results of seven gonadotropin releasing hormone (GnRH) loading tests are presented with special respect to the changes of melatonin level. The tests were carried out after a withdrawal bleeding triggered by progesterone (100 mg for 5 days) and plasma FSH, LH, prolactin and melatonin level were determined. The initial melatonin values were between 3.9 and 35.7 pg/ml and were in inverse ratio with the basal gonadotropin levels. In the case of reactive hypophyseal response the melatonin level decreased in every case in inverse ratio with the increase of gonadotropins. In one case, after the GnRH administration there was no increase in gonadotropin production and at the same time the melatonin secretion remained unchanged. According to our examinations the melatonin secretion during the GnRH loading test showed a good correlation with the changes of gonadotropins.

Anovulation↗
PubMed1992

[Gonadotropin releasing hormone loading test with bromocryptin therapy: a new possibility in the differential diagnosis of normo-prolactinaemic anovulation].

An anovulation group with normal basal prolactin level (less than 600 mU/l) was found during GnRH loading tests. After GnRH administration there was a definite increase in prolactin value together with an insufficient hypophyseal response. Bromocriptine treatment was commenced on the 10th day (daily 2.5 mg) before carrying out the GnRH loading tests again. During the repeated tests prolactin levels remained normal, basal FSH and LH values increased and reactive hypophyseal responses occurred. On the basis of the examination a group ("latens hyperprolactinemia") responding with increased prolactin production during GnRH administration was found. This higher prolactin level inhibits gonadotropin release from hypophysis. In these cases ovulation induction with bromocriptine is adviseable in spite of basal prolactin level is normal.

Anovulation↗
PubMed1991

[Pulsatile gonadotropin-releasing hormone substitution following excision of a craniopharyngioma with suprasellar invasion].

Craniopharyngeoma growing suprasellary attacks the medio-basal region of hypothalamus, that leads to the stopping of the production of gonadotropin releasing hormone. In connection with the case of a 15-year-old girl who had partial extirpation of craniopharyngeoma the authors write about the favourable endocrine effect of pulsatile gonadotropin releasing hormone treatment. Through giving gonadotropin releasing hormone every 90 minutes in 20 micrograms doses menstruation cycle and ovulation was performed. Beside surgical treatment hormonal substitution plays an important role in the treatment of additional endocrine symptoms.

Adolescent↗
PubMed1990

Pulsatile gonadotropin releasing hormone substitution following extirpation of suprasellar craniopharyngioma.

A craniopharyngioma growing suprasellarly attacks the medio-basal region of the hypothalamus, interrupting the production of gonadotropin-releasing hormone. In the case of a 15-year-old girl who underwent partial extirpation of craniopharyngioma, favorable endocrine effects were obtained by pulsatile gonadotropin-releasing hormone treatment. Gonadotropin-releasing hormone administered in a dose of 20 micrograms every 90 min resulted in the achievement of a menstrual cycle and ovulation. Together with surgical treatment, hormonal substitution plays an important role in the treatment of endocrine symptoms.

Adolescent↗
PubMed1989

[Treatment of functional infertility, caused by luteal deficiency, with pulsatile perfusion of gonadotropin releasing hormone].

The prehistory of cyclical development of corpus luteum goes back to early follicular phase. Reduced secretion or defective rhythm of gonadotropin releasing hormone (GnRH) can later cause unperfect ovulation or corpus luteum insufficiency. The authors carried out a low-dose pulsatory GnRH-treatment on eight patients with luteal insufficiency, who were earlier treated unsuccessfully with other ovulation-inductive methods (clomiphene, hCG, bromocryptin). As a result of GnRH administration hypertherm period expanded, plasma progesteron level increased and three pregnancies occurred. In their opinion exogenic administration of GnRH results in an improvement of luteal function.

Corpus Luteum Hormones↗
PubMed1989

[Changes in the prolactin level under the effect of pulsatile infusion of gonadotropin releasing hormone].

Plasma prolactin levels were measured in 18 GnRH loading tests and, in 24 cycles involving treatment with GnRH. During 17 GnRH loading tests the prolactin levels production remained virtually unchanged, the individual GnRH pulses not raising the prolactin level. In one case the GnRH loading test led to a considerable rise in prolactin level, which is considered to be a pathological prognostic sign as concerns subsequent GnRH treatment. During unsuccessful pulsatile GnRH treatment, the prolactin secretion in monotonous, while treatment resulting in ovulation, even in hyperprolactinaemia cases, is accompanied by higher prolactin levels in the preovulation and luteal periods than in the early follicular phase.

Adult↗
PubMed1989

Ovulation induction with pulsatile administration of human menopausal gonadotropin.

Ovulation induction was performed by the pulsatile administration of subcutaneous human menopausal gonadotropin (hMG). Treatment was started with a daily dose of 75 IU hMG (in a 90% distribution), then it was increased to 150 IU depending on the oestradiol level of the plasma and on the result of folliculometry. Of 10 cycles treated ovulation was induced in 7 cases and two pregnancies occurred. In two cases, following a previous unsuccessful intramuscular hMG treatment, ovulation was induced. Hyperstimulation did not occur. The pulsatile s.c. administration of hMG seems to be an adequate ovulation-induction method in ovulatory disorders of hypothalamo-hypophyseal origin and is a good substitute for the missing, endogenous gonadotropin secretion of inadequate pace.

Adult↗
PubMed1988

Up-to-date surgical management of tubal infertility due to inflammations of the pelvis.

A total of 87 refertilization operations in the distal tubal segment are reported. Tubal obstructions developed following inflammations of the pelvis. Hysterosalpingography and laparoscopy were used to learn about the patients' anatomy and these served as bases for assessing the changes of pregnancy following recanalization. The interventions were made by applying up-to-date microtechnical methods and instruments. Among the causes of tubal infertility, the interruption of the first pregnancy showed a marked prevalence. The 20 pregnancies that ensued correspond to a success rate of 23%. Mature deliveries occurred in 17 cases. A considerable proportion of the pregnancies occurred within a year of the operation. The effectiveness is mainly influenced by adhesions in the pelvis and the characteristics of the distal tubal segment. The surgical solution is worth attempting when the expected chances are over 20%.

Adult↗