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Biomedical subjects

S Korol

Publications and source records attributed to S Korol.

At least 19 recordsLinked to original sources

[Visual disorders, functional defects and vitamin deficiencies].

The comparison between complaints, functional defects and vitamin deficiencies is reported for several professional groups characterized by different work conditions. Results suggest that complaints are an useful indicator of visual load and that retinal sensitivity to the light is especially tried. Longitudinal studies are required to verify whether some functional alterations on the aging process of the eye can be aggravated by a visual overload. Visual complaints, functional defects and vitamin deficiencies as indicators of visual load.

Adult

[The computerized tomography in findings posttraumatic hematoma (author's transl)].

The authors report two cases of posttraumatic hematoma in the orbit. The first patient presents an unilateral amaurosis through indirect trauma of the optic nerve. The computerized tomography reveals a hematoma of the optic nerve sheath, confirmed by surgery. The second patient presents a posttraumatic limitation of the ocular motility and the computerized tomography reveals a hematoma of two extraocular muscles.

Adult

[Ocular fatigue induced due to work on visual screens].

It appears that visual complaints, as they are expressed by numerous TV screen operators, are associated with common eye defects. Our results based on a survey with questionnaires and visual testing sustain such an hypothesis. As a consequence, solving eye problems at TV screens requires both the improvement of visual displays and the visual adaptation of users. If impossible working-time should be reduced.

Eye

[Visual evoked potentials in patients suspected of multiple sclerosis].

23 patients with symptoms suggestive of multiple sclerosis were examined with regard to the responses evoked by low frequency flash and also by flicker stimulation. The results obtained by flicker were compared with those reported on the responses evoked by different visual stimuli. The survey of the three parameters of analysis of the visual-evoked responses showed a very high proportion of pathological values.

Adolescent

Psychophysical flicker thresholds and ERG flicker responses in congenital and acquired vision deficiencies.

Psychophysical flicker thresholds and ERG flicker responses were compared with Farnsworth's 100-hue colour test data in cases of congenital and acquired vision deficiences. The results, evaluated in term of sensitivity and specificity lead to some practical and theoretical suggestions. In most cases, flicker responses and colour tests results were better than other classical tests for evaluating the first signs or gravity importance of a macular disturbance. Relatively minor differences between the 3 tests may be related to the observed or supposed extension of lesion in the macular area, but in some cases the observed functional changes can be understood only by admitting some lateral effect from one area to another. Generally acquired colour differences are associated with flicker response changes. In congenital red-green blindness of different gravity, moderate abnormal white light flicker responses could be observed. But they do not seem to be associated clearly with a type and gravity of the deficiency. With coloured stimuli, the difference between normal and red-green colour-blindness is more clear-cut, and red-blind can be discriminated from green-blind. Subclinical retinal pathology as well as specific stimulus conditions in normal and red-green colour-blind subjects reveal some non-linear processes in the low-frequency range of the temporal attenuation characteristics.

Adolescent

[Degenerative ocular retinal albinism in a girl ten years old (author's transl)].

Ocular albinism with myopia and impaired vision (R.E. 0.2; L.E. 0.6), but without nystagmus, were observed in a 10-year-old girl. The electrophysiological tests indicate, in addition, the presence of a tapetoretinal degeneration. It is assumed that the patient is carrier of two genes, a sex-linked one responsible for albinismus solum fundi and a second one of autosomal-recessive type, responsible for the tapetoretinal degenerartion.

Albinism

[Chiasmatic syndrome--clinical value of the visual evoked responses (VER) to the diagnosis (author's transl)].

The VER is compared with that of other neuroophthalmological examinations in 25 patients presenting lesions of the anterior optic pathways (of which 18 were of an expansive nature). The authors believe that visual field plotting and VER are indispensable complementary examinations, giving results which orientate subsequent investigations towards a chiasmatic or prechiasmatic syndrome. In 15 cases of chiasmatic syndrome of tumoral origin (thus in 30 optic nerves), visual fields and VER showed early pathological changes. In originally unilateral forms, VER changes are usually bilateral even when visual field changes are still unilateral. This draws attention to the fact that some process may be injuring either both optic nerves, or the optic chiasma. In cases where the patients are too young, or collaboration is insufficient, to enable visual fields to be plotted, evolution may be studied by VER. In post-surgical follow-up, or during therapy (eg. irradiation), VER recuperation carries a good prognosis. If no VER improvement occurs the expansive process has caused irreparable optic nerve atrophy. Nevertheless, frequent visual field study remains the best diagnostic method of chiasmatic syndromes and their evolution. An earlier diagnosis may be made in the majority of cases by the dual study of visual fields and VER.

Adenoma

[Value of functional and electrophysiological studies in amblyopia].

In a group of patients suffering from amblyopia, the authors confront the results after orthoptic treatment with data provided by functional and electrophysiological examination. In 37 patients the clinical diagnosis of functional amblyopia had been made, but in 8 of these cases complimentary functional and electrophysiological examinations showed organic perturbations. This explains the failure, in these cases, of the orthoptic treatment. In the remaining 29 patients, clinical forms of functional amblyopia were found. In this group, the authors studied 20 cases showing no improvement with treatment: in 15 out of the 20 the VERs were pathological. In the 9 remaining cases which have showed improvement the VER'S were never abnormal. VER study can be undertaken, without general anaesthesia, as from 3 to 4 years of age. The authors conclude that all clinical forms of amblyopia should undergo VER investigation: patients showing pathological changes should be excluded from orthoptic treatment, from which they have no possibility of deriving benefit.

Amblyopia

[Evoked visual potentials in tapeto-retinal degeneration].

A study of the behaviour of V.E.P. latencies and amplitudes in 247 eyes suffering from different clinical forms of chorio-retinal degenerations is presented. In 147 eyes the E.R.G. and the V.E.R. were simultaneously recorded, and this group was used for studying the relation ship between E.R.G., V.E.P. and visual acuity. The authors are of the opinion that the V.E.P., in that it investigates particularly the macular region, provides a clinical test of real interest in the prognosis of visual acuity in a known clinical context.

Choroid

[Complex repairs for loss of eyelid substance (author's transl)].

The repair of large defects of the lid region may require complex reconstruction using skin, tarsus and conjunctival grafts or flaps. The authors have classified the lesions in three groups: inner canthus, lower lid and upper lid. For each group, the more applicable technics are described.

Cartilage

In vivo effects of glycine on retinal ultrastructure and averaged electroretinogram.

Glycine, when injected intravitreally, has an inhibitory action on the electroretinogram (ERG) of the rabbit resulting in a transient loss of the oscillatory potentials of the b-wave. This inhibitory action is reversible within 24 h after glycine injection. In autoradiographs, after [3H] glycine administration, the radioactive label is mainly found over the inner nuclear layer (INL) and inner plexiform layer (IPL) without predilection of specific cell types and/or synapses. Electron microscopy reveals cytopathological changes in amacrine cells, in particular their cell membranes. These changes are conspicuous especially 1-2 h after the injection and the cells become normal again within 24 h. It is concluded that glycine has an inhibitory action upon the rabbit ERG in vivo. This action, on the basis of our morphological observations under our experimental conditions, may be due to an overall somatic membrane action rather than to an action as inhibitory neurotransmitter at the synaptic level. The reversible cellular lesions of amacrine cells after glycine administration with a concomitant, transient loss of oscillatory potentials (OP) supports the hypothesis that the cellular origin of OP is situated in amacrine cells.

Animals