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Biomedical subjects

S Korossy

Publications and source records attributed to S Korossy.

At least 19 recordsLinked to original sources
PubMed1994

Presynaptic and postsynaptic effects of mercuric ions on guinea-pig ileum longitudinal muscle strip preparation.

The toxic effect of mercuric ions on intestinal cholinergic neurotransmission was investigated in vitro. Hg2+ inhibited the evoked release and enhanced the resting release of ACh. Smooth muscle contraction was irreversibly inhibited by Hg2+ in a concentration-dependent manner, and Na2EDTA did not antagonize this effect. We also investigated if Hg2+ enters the nerve terminal through Ca(2+)-channels, or Na(+)-channels, or both. The effects of mercuric ions obtained in our study were completely abolished by the combined administration of TTX and Co2+. It is suggested that the site of the action of mercuric ions is intracellular. We concluded that Hg2+ may interfere with cholinergic transmission by blocking [Ca2+]o-dependent release of ACh and by enhancing [Ca2+]o-independent resting release of ACh. The effect of Hg2+ was not only presynaptic since it also inhibited the effect of ACh on smooth muscle.

Acetylcholine↗
PubMed1988

Epidemiology of nickel allergy: results of a follow-up analysis of patients with positive patch tests to nickel.

In a previous paper, we reported on nickel sensitivity in 2400 consecutive patients in 5 countries. 3 years later, we reassessed 104 of the 157 nickel-positive patients of this former study and found 13 now to be negative to nickel sulphate. Nearly all the others can no longer tolerate nickel contact. 68 patients were free from nickel dermatitis, 16 showed a very mild eczema or dyshidrosis, and 13 were suffering from chronic hand dermatitis. 42 of 104 patients had changed their occupation, 36 successfully, with clearance of skin lesions. Rehabilitation by avoidance of nickel-containing costume jewelry, wrist-watches and clothing buckles, and by change of occupation, is possible and necessary.

Dermatitis, Contact↗
PubMed1987

Epidemiology of nickel allergy.

In 2400 consecutive patients at 8 clinics in 5 countries, nickel hypersensitivity was found in 176 cases (7.3%), 19 male (2.1%) and 157 female (10.5%). The incidence ranged from 15 to 38 cases in 300 patients of every department (5.0% Sofia to 12.7% Erfurt). 60.6% of the nickel positives were schoolgirls or younger than 25 years. The exposure time was 3 years, in 49% 1 year or shorter. Most cases (75%) are not occupationally acquired, but due to costume jewelry (31.8%), wrist watches (23.3%), metal clothing buckles (3.4%) including jeans buttons. Job dependent nickel dermatitis is often (36/51 cases) linked with wet work. Atopic dermatitis was found in 8.3% of female nickel allergy. Nickel positivity without a dermatitis history was seen in 9/176 cases (5%). Nickel allergy will become a sex-indifferent phenomenon in Europe, because of the changing customs of adornment.

Dermatitis, Contact↗
PubMed1983

[Frequency, relevance and latency of chemical allergy in hospitalized patients in Budapest].

Epicutaneous tests were performed 1979 using a standard test series of 31 substances on 436 hospitalized patients. The positive results were analysed for relevance and latency. Occupational and environmental origin of sensitization was looked for in both sexes. The order of allergens causing contact dermatitis in women was: Dichromate, phenylbutazone, cobalt (as concomitant allergy?), balsam of Peru, p-phenylene diamine, chloramphenicol, phenyl-isopropyl-p-phenylene diamine, N-phenyl-cyclohexyl-p-phenylene diamine (as concomitant allergy?), mercury amidochlorate, formaldehyde, mercury bichloride (as concomitant allergy?). In men the order of frequency was: dichromate, phenyl-isopropyl-p-phenylene diamine, N-phenyl-cyclohexyl-p-phenylene diamine (as concomitant allergy?), cobalt (as concomitant allergy?), p-phenylene diamine, chloramphenicol, formaldehyde, phenylbutazone, balsam of Peru, mercury amidochlorate, mercury bichloride (as concomitant allergy?). The mode and degree of exposure are important factors influencing the composition of the spectrum of allergens. It is essential to distinguish between relevant and latent sensitization primarily in occupational exposure when decisions concerning the patient's future occupation must be made.

Dermatitis, Contact↗
PubMed1982

Sensitizing activity to egg protein of an A1PO4-adjuvant full-virus influenza vaccine.

The sensitizing activity to egg protein of an A1PO4-adjuvant purified and concentrated influenza-A vaccine was examined in animal experiments and in man. Intravenous injection of ovalbumin caused anaphylactic symptoms and/or fatal anaphylactic shock in prevaccinated guinea-pigs. Ovalbumin-specific antibodies detectable by the passive haemagglutination reaction (PHA) appeared in the blood serum of the vaccinated animals. Model experiments with purified ovalbumin suggested that 1 human dose of the vaccine contained egg protein in the range from 0.1 to 1 ng, and that the antigenic effect of the vaccine grew to more than 10(3)-fold by its adsorption to A1PO4 gel. Adults who in previous years had been immunized with similarly prepared influenza vaccine several times responded with mild reactions; symptoms suggestive of hyperergy did not occur, irrespective of the vaccination history. In the prevaccination serum sample of some vaccines, ovalbumin-specific PHA antibodies were found up to titres independent of the number of the previous immunizations. The concentration of the ovalbumin-specific antibodies of the IgE class was by several orders of magnitude lower in the postvaccination samples than in the serum of some patients hypersensitive to egg protein.

Adjuvants, Immunologic↗
PubMed1981

[Frequency and relevance of some cross-, concomitant- and pseudo-cross allergies (author's transl)].

Examples of cross-, concomitant- and pseudo-cross allergies are discussed based on the results obtained in a series of patch tests made with 31 chemical allergens. Special attention is paid to the relevance of positivity. Para-group allergy is analysed as an example of cross-allergy. Analysis of various combinations of allergy to p-phenylene diamine and phenylisopropyl-p-phenylene diamine suggests that in addition to the classical cross-allergy, concomitant sensitization may also occur. Concomitant allergy to three metals (chromium, cobalt and nickel) is discussed. Concomitant sensitization to chromium and cobalt has been found to occur most frequently. Associated positivity to various aromatic balsam-like substances (balsam of Peru, turpentine, colophony, wood tar) has been interpreted as pseudo-cross-allergy.

Allergens↗
PubMed1979

[Prostaglandins in skin blisters of bullous erysipelas, dermatitis herpetiformis and herpes gestationis (author's transl)].

The PGE2 and PGF2 alpha content of bullae developing spontaneously on the skin was investigated by radioimmunoassay in 12 patients with different skin diseases. The PGF2 alpha level was also established in the plasma and urine. In herpes gestationis, dermatitis herpetiformis and bullous erysipelas the PGE2 and PGF2 alpha content of the bullae considerably exceeded the plasma and urinary PG levels. The findings were thought to be in relation with the acute inflammation of the skin, the mechanism of bulla formation as well as with pruritus.

Adult↗