[Professor Jerzy Giełdanowski].
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History, 20th Century↗
Biomedical subjects
S Kowalczyk-Bronisz
Publications and source records attributed to S Kowalczyk-Bronisz.
Studies on effect of pesticide Chlorfenwinfos on mouse immune system.
The effect of organophosphate pesticide--Chlorfenwinfos on the selected parameters of humoral and cellular immunologic response in mice was investigated. Hematologic and histologic examinations were run parallelly. The animals were treated with pesticide p.o. during 90 days in doses 1/100, 1/50 and 1/25 of LD50. It was found that Chlorfenwinfos exerts immunotropic effect. After high doses the strong suppressive effect in PFC and EA rosettes was observed. Significant involution of thymus was noted. Il-1 activity, DTH reaction (24 h after challenge) and endogenous and exogenous spleen colonies were stimulated. It seems that immunotropic effect of this pesticide is reversible. Three weeks after the exposure to this compound had been stopped, PFC, IgG and IgM level came back to the normal value.
Animals↗
Studies on affinity of pesticide Unden--2-isopropoxyphenyl N-methylcarbamate to immunological system.
The effect of 2-isopropoxyphenyl methylcarbamate (Unden) (10- or 30-day exposure) on the selected parameters of humoral and cellular immunological response in mice was investigated. Hematologic and histologic examinations were run parallelly. It was noted that this compound exerts immunotropic effect. Immunosuppressive effect was prevailing (PFC, GvH, humoral response to SRBC) but in some tests also stimulatory effect was observed (number of B cells, Il-1, stimulation and proliferation of reticular cells were also observed in the spleen and lymphatic nodes). Immunotropic effect of Unden was reversible - after the exposure to pesticide had been stopped, the investigated parameters of the immunological system activity (PFC, IgG, IgM) spontaneously came back to the norm.
Animals↗