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S Krumbholz

Publications and source records attributed to S Krumbholz.

At least 19 recordsLinked to original sources
PubMed1998

Crystallographic studies on the ribosome, a large macromolecular assembly exhibiting severe nonisomorphism, extreme beam sensitivity and no internal symmetry.

Crystals, diffracting best to around 3 A, have been grown from intact large and small ribosomal subunits. The bright synchrotron radiation necessary for the collection of the higher-resolution X-ray diffraction data introduces significant decay even at cryo temperatures. Nevertheless, owing to the reasonable isomorphism of the recently improved crystals of the small ribosomal subunits, reliable phases have been extracted at medium resolution (5-6 A) and an interpretable five-derivative MIR map has been constructed. For the crystals of the large subunits, however, the situation is more complicated because at higher resolution (2.7-7 A) they suffer from substantial radiation sensitivity, a low level of isomorphism, instability of the longest unit-cell axis and nonisotropic mosaicity. The 8 A MIR map, constructed to gain insight into this unusual system, may provide feasible reasoning for the odd combination of the properties of these crystals as well as hints for future improvement. Parallel efforts, in which electron-microscopy-reconstructed images are being exploited for molecular-replacement studies, are also discussed.

Animals↗
PubMed1983

[Sacrococcygeal chordomas--peculiarities of their morphology, clinical aspects, diagnosis and therapy].

Sacro-coccygeal chordomas are discussed with respect to particularities of their morphology, clinical aspects, diagnosis and therapy, including two cases treated by the authors. The consideration of almost always ignored or misinterpreted initial lumboischialgia is pointed out. Because of the primary benign growth of these tumours, early diagnosis and immediate radical surgical treatment would possibly increase the survival chance of their carriers or even--so far only a speculation--lead to permanent curing.

Aged↗
PubMed1983

[Artificial stenosis of the left vertebral artery in the rabbit].

Animal experiments were carried out to clarify if a unilateral stenosis of the vertebral artery leads to a typical symptomatology and if a surgical therapy may be promising. The left vertebral artery was stenosed in 12 rabbits. The result was checked for 3 weeks electro-encephalographically and doppler-sonographycally. Conclusions after this long-term experiment: 1) A unilateral stenosis of the vertebral artery leads to a brain stem symptomatology. 2) This symptomatology shows determined development in dependence of the time. 3) Correlates of the brain stem lesion by vertebral stenosis were discovered electroencephalographically they were increased by specific activation methods. 4) The expected success produced the operative removal of the artificial stenosis of the vertebral artery. 5) The blood flow of the vessels which are of interest could be controlled by means of the ultrasound doppler-sonography during the whole experiment.

Animals↗
PubMed1982

[The treatment of carotico-cavernous fistulas, past and present (author's transl)].

Even at the present time, the surgical treatment of carotico-cavernous fistulas still presents problems. The author gives a brief review of the diagnosis, incidence and pathology and a detailed survey of the earlier methods of treatment, as well as those used at present, particular attention being drawn to the intravascular invasive procedures. It appears appropriate to rationalize the methods used today, namely ligation, embolization and coagulation. The author describes the use of his own successful method, in which injection of a tissue adhesive with an acrylate base (FIMOMED) through a double lumen microcatheter remains the method of choice.

Arteriovenous Fistula↗
PubMed1982

[Problem of the early recognition of spinal cord tumors].

Two thirds of a group of patients with 40 space-restricting processes in the region of the spinal canal were submitted to an operation in the stage of an incomplete transverse syndrome. A striking fact was that these patients had tumours of different histological classifications which were localised in the thoracic and thoraco-lumbal transitional region Tumours in the cervical and cervico-thoracic transitional region were mainly operated on in their early stages. They had a considerably shorter period of anamnesis from the beginning of the clinical symptoms up to the operation. A cause of the different periods of anamnesis with different localisations is discussed.

Diagnosis, Differential↗
PubMed1982

[Diagnosis and surgical indications in brachial plexus injuries].

The application of microsurgery is suited to enlarge the indication to operative interventions in lesions of the brachial plexus and to improve the results of their neurosurgical treatment. On the basis of a follow-up study of an adequate clinical material consisting of 16 patients during the last 4 years the results of the treatment report and postulates are formulated concerning the pre-examinations, the indication and the neurosurgical approach.

Adolescent↗
PubMed1981

[Diagnosis of brain abscesses by angiography and nuclear medicine methods].

In most cases, abscesses are formed otogenically or rhinogenically. The clinical symptoms may be uncharacteristic. The diagnosis is made by employing nuclear-medical and angiographic procedures. In 40 patients suspected of having a cerebral abscess, transfemoral cerebral angiography and in 14 cases gammaencephalography or cerebral scintigraphy was carried out. Angiographically, cerebral abscesses mostly appear as avascular growths while nuclear-medical or localised increase in the activity concentration suggests a pathological finding. The symptoms are uncharacteristic and can only be attributed to an abscess process in connection with clinical and paraclinical findings.

Adolescent↗
PubMed1981

[Surgical treatment of occlusive intracranial cerebrovascular disorders (author's transl)].

Management of intracranial cerebral circulatory disorders represents a relatively new interesting and delicate field in neuro--and vascular surgery. Today, we know the reconstructive and constructive microsurgical approach to brain vessels in man. Most surgeons practise the constructive procedure. The authors criteria for selection of patients are presented. The aim of surgical therapy is to increase the blood flow because retrograde blood supply by the collateral system is anatomically or functionally insufficient.

Aged↗