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Biomedical subjects

S Kuhr

Publications and source records attributed to S Kuhr.

12 recordsLinked to original sources
PubMed2005

Submicrometer position control of single trapped neutral atoms.

We optically detect the positions of single neutral cesium atoms stored in a standing wave dipole trap with a subwavelength resolution of 143 nm rms. The distance between two simultaneously trapped atoms is measured with an even higher precision of 36 nm rms. We resolve the discreteness of the interatomic distances due to the 532 nm spatial period of the standing wave potential and infer the exact number of trapping potential wells separating the atoms. Finally, combining an initial position detection with a controlled transport, we place single atoms at a predetermined position along the trap axis to within 300 nm rms.

Journal Article↗
PubMed2003

Coherence properties and quantum state transportation in an optical conveyor belt.

We have prepared and detected quantum coherences of trapped cesium atoms with long dephasing times. Controlled transport by an "optical conveyor belt" over macroscopic distances preserves the atomic coherence with slight reduction of coherence time. The limiting dephasing effects are experimentally identified, and we present an analytical model of the reversible and irreversible dephasing mechanisms. Our experimental methods are applicable at the single-atom level. Coherent quantum bit operations along with quantum state transport open the route towards a "quantum shift register" of individual neutral atoms.

Journal Article↗
PubMed2002

Capture and release of a conditional state of a cavity QED system by quantum feedback.

Detection of a single photon escaping an optical cavity QED system prepares a nonclassical state of the electromagnetic field. The evolution of the state can be modified by changing the drive of the cavity. For the appropriate feedback, the conditional state can be captured (stabilized) and then released. This is observed by a conditional intensity measurement that shows suppression of vacuum Rabi oscillations for the length of the feedback pulse and their subsequent return.

Journal Article↗
PubMed2001

Deterministic delivery of a single atom.

We report the realization of a deterministic source of single atoms. A standing-wave dipole trap is loaded with one or any desired number of cold cesium atoms from a magneto-optical trap. By controlling the motion of the standing wave, we adiabatically transport the atom with submicrometer precision over macroscopic distances on the order of a centimeter. The displaced atom is observed directly in the dipole trap by fluorescence detection. The trapping field can also be accelerated to eject a single atom into free flight with well-defined velocities.

Journal Article↗
PubMed2000

Single atoms in an optical dipole trap: towards a deterministic source of cold atoms

We describe a simple experimental technique which allows us to store a small and deterministic number of neutral atoms in an optical dipole trap. The desired atom number is prepared in a magneto-optical trap overlapped with a single focused Nd:YAG laser beam. Dipole trap loading efficiency of 100% and storage times of about one minute have been achieved. We have also prepared atoms in a certain hyperfine state and demonstrated the feasibility of a state-selective detection via resonance fluorescence at the level of a few neutral atoms. A spin relaxation time of the polarized sample of 4.2+/-0.7 s has been measured. Possible applications are briefly discussed.

Journal Article↗
PubMed2000

Intergovernmental preparedness and response to potential catastrophic biological terrorism.

The 20th century is replete with examples of the use of biological weapons in times of war. Today, it is only a matter of time before terrorists find a way to develop and deploy biological weapons as well. Because of the narrow window of opportunity in which treatment and prophylaxis can positively affect the outcome of those exposed to and infected by biological weapons, aggressive public health surveillance is the best early defense. A casualty management and mass prophylaxis campaign will require coordination at all levels of government involving many agencies.

Biological Warfare↗
PubMed1994

[Antimycobacterial acting carbazole derivatives].

Carbazoles are synthesized and tested for antimycobacterial properties (M. tuberculosis H 37 Ra, Middlebrook-7H9-broth). The different antimycobacterial properties of diastereomeres are examined using compounds 32 and 33, those of a racemic compound and the (+)-enantiomer are tested with (+/-)-12/(+)-12 and (+/-)-5/(+)-5, respectively. (+)-12 is prepared by enantioselective synthesis.

Antitubercular Agents↗
PubMed1993

Determination of flavone C-glycosides in tea.

An HPLC method for the determination of flavone C-glycosides (FCG) from black tea has been developed. Sample clean-up was accomplished by means of polyamide column chromatography, followed by enzyme hydrolysis of interfering compounds such was flavonol glycosides and a second polyamide column chromatographic step. Using HPLC with gradient elution and photodiode array detection eight FCG were separated. Seven FCG were isolated by means of preparative HPLC. Identification was carried out using co-chromatography, FAB(Fast Atom Bombardment)-mass spectrometry and various nuclear magnetic resonance techniques. Apigenin 6-C-glucosyl-8-arabinoside (schaftoside) and apigenin 6-C-arabinosyl-8-C-glucoside (isoschaftoside) as well as luteolin 8-C-glucoside (orientin) and luteolin 6-C-glucoside (isoorientin) have been detected in tea for the first time. Three of the other compounds have been identified as apigenin 8-C-glucoside (vitexin), apigenin 6-C-glucoside (isovitexin) and apigenin 6,8-di-C-glucoside (vicenin-2). Their occurrence in tea has been previously reported. From its UV spectrum another compound was concluded to be an apigenin glycoside. The FCG were quantified in a variety of teas of different origins (16 black, two green and one oolong). The total amounts of the FCG were 0.48-2.69 g/kg dry weight. The FCG pattern of teas of different origins were similar to each other and no origin-dependent characteristics have yet been observed. Small amounts of FCG (1.2-2.2 mg/kg) were detected in hydrolysates of high relative molecular mass fractions (Mr > 5000) of a black tea liquor.

Apigenin↗
PubMed1992

Chromatography of tea constituents.

Modern chromatographic techniques such as high-performance liquid chromatography are currently the most helpful approach to the routine analysis of and research of non-volatile tea constituents. Using these techniques some errors in the more classical analytical techniques could be detected. Unfortunately, some of these methods of analysis are still in widespread use, even as official methods. However, knowledge of especially the polyphenols in tea is still lacking, and for many of the minor polyphenols no chromatographic methods for the determination exist.

Alkaloids↗