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S Kusakawa

Publications and source records attributed to S Kusakawa.

43 records · Page 3Linked to original sources
PubMedDate not supplied

Comparison of plasma component levels in four strains of female mice with different mammary tumour potentials.

Based on the importance of general metabolic activity to mammary tumourigenesis, plasma component levels were examined at 6 and 10 months of age in female virgin mice of four strains, which in mammary tumour potential, rank in the descending order of SHN, GR/A, SLN and C3H/He. The plasma aspartate aminotransferase level elevated from 6 to 10 months of age in the SHN and GR/A, but not in the SLN and C3H/He strains. The total bilirubin level was higher in the former two strains than the latter two at both 6 and 10 months. The blood urea nitrogen level was highest in SHN. C3H/He had the lowest plasma levels of these components as well as amylase at both ages. The results indicate the signifcance to the mammary tumourigenic potential of plasma levels of certain components related to general metabolic activity.

Alanine Transaminase↗
PubMedDate not supplied

Relationship between incidence and onset age of mammary tumours and uterine adenomyosis in four strains of mice: comparison with the findings of 40 generations previously.

Like most characteristics studied in research, mammary tumourigenesis and uterine adenomyosis in mice are regulated by both genetic and environmental factors and information about the degree of participation of each factor in these lesions is important in the use of mice for investigations. Several parameters on spontaneous mammary tumours and uterine adenomyosis in four strains of mice with different potentials for these lesions were compared in those before and after more than 40 generations or more than 10 years (1987). During these periods, the mice were exposed to several different intangible or unavoidable environmental factors, although they are quite stable genetically by maintenance with full-sib mating. Nevertheless, small differences were observed between the present and 1987 regarding strain-related characteristics, such as the onset age, the cumulative incidence and the growth of mammary tumours and uterine adenomyosis. It is suggested that genetics is more influential than environmental factors regarding the maintenance of strain-related characteristics of mammary and uterine lesions.

Age of Onset↗
PubMedDate not supplied

Results from an international survey of Kawasaki disease in 1979-82.

Kawasaki disease is a febrile illness of unknown etiology affecting mainly children younger than five years, 20% of whom develop coronary artery aneurysms. The disease was first reported in Japan, but case reports have come from several countries; epidemics apparently occur every two to three years. A committee of the International Society and Federation of Cardiology (ISFC) collaborated on an international, retrospective survey in mid-1983 through 1984, asking about Kawasaki disease cases seen in 1979-82 and their outcomes. Responses were received from 53 countries; reports from 20 countries indicated that no cases were seen in the years surveyed. Kawasaki disease did not always follow the Japanese pattern. An indication of 'epidemic' increases was found in some years in some countries. Recognition of Kawasaki disease varies considerably, but further educational efforts are likely to uncover additional cases, and intensive epidemiological efforts would be possible in a number of countries.

Child, Preschool↗
PubMedDate not supplied

Surgical experience with coronary arterial sequelae of Kawasaki disease in children.

The coronary arterial sequelae due to Kawasaki disease have been treated surgically in five children ranged from 6 to 9 years old. The procedures were aortocoronary bypass surgery in all cases, coronary artery aneurysmectomy in one case and left ventricular aneurysmectomy in one case. The early results of operated cases have been good with the graft patency of 86% confirmed by angiography one month after surgery. The characteristic features of coronary artery damage in patients with Kawasaki disease are coronary artery aneurysms, which manifest wall irregularity, thrombus, calcification and stenosis. The significant stenosis of coronary artery could often be observed at the inlet or outlet of the aneurysm in major coronary artery branches. Although the early results of aortocoronary bypass surgery in the children with Kawasaki disease have been good, long-term follow up is mandatory to investigate the status of autogenous saphenous vein grafted in children.

Angiocardiography↗