Biomedical subjects

S L Braunstein

Publications and source records attributed to S L Braunstein.

4 recordsLinked to original sources

PubMed2001

Telecloning of continuous quantum variables.

We propose entangled (M+1)-mode quantum states as a multiuser quantum channel for continuous-variable communication. Arbitrary quantum states can be sent via this channel simultaneously to M remote and separated locations with equal minimum excess noise in each output mode. For a set of coherent-state inputs, the channel realizes optimal symmetric 1-->M cloning at a distance ("telecloning"). It also provides the optimal cloning of coherent states without the need of amplifying the state of interest. The generation of the multiuser quantum channel requires no more than two 10log10[(root square[M]-1)/(root square[M]+1)] dB squeezed states and M beam splitters.

Journal Article↗

PubMed2001

Optimal cloning of coherent states with a linear amplifier and beam splitters.

A transformation achieving the optimal symmetric N-->M cloning of coherent states is presented. Its implementation requires only a phase-insensitive linear amplifier and a network of beam splitters. An experimental demonstration of this continuous-variable cloner should therefore be in the scope of current technology. The link between optimal quantum cloning and optimal amplification of quantum states is also pointed out.

Journal Article↗

PubMed2000

Impossibility of deleting an unknown quantum state

A photon in an arbitrary polarization state cannot be cloned perfectly. But suppose that at our disposal we have several copies of a photon in an unknown state. Is it possible to delete the information content of one or more of these photons by a physical process? Specifically, if two photons are in the same initial polarization state, is there a mechanism that produces one photon in the same initial state and the other in some standard polarization state? If this could be done, then one would create a standard blank state onto which one could copy an unknown state approximately, by deterministic cloning or exactly, by probabilistic cloning. This could in principle be useful in quantum computation, where one could store new information in an already computed state by deleting the old information. Here we show, however, that the linearity of quantum theory does not allow us to delete a copy of an arbitrary quantum state perfectly. Though in a classical computer information can be deleted (reversibly) against a copy, the analogous task cannot be accomplished, even irreversibly, with quantum information.

Journal Article↗

PubMed1993

Effect of cell arrangement and interstitial volume fraction on the diffusivity of monoclonal antibodies in tissue.

We present theoretical calculations relating the effective diffusivity of monoclonal antibodies in tissue (Deff) to the actual diffusivity in the interstitium (Dint) and the interstitial volume fraction phi. Measured diffusivity values are effective values, deduced from concentration profiles with the tissue treated as a continuum. By using homogenization theory, the ratio Deff/Dint is calculated for a range of interstitial volume fractions from 10 to 65%. It is assumed that only diffusion in the interstitial spaces between cells contributes to the effective diffusivity. The geometries considered have cuboidal cells arranged periodically, with uniform gaps between cells. Deff/Dint is found to generally be between (2/3) phi and phi for these geometries. In general, the pathways for diffusion between cells are not straight. The effect of winding pathways on Deff/Dint is examined by varying the arrangement of the cells, and found to be slight. Also, the estimates of Deff/Dint are shown to be insensitive to typical nonuniformities in the widths of gaps between cells. From our calculations and from published experimental measurements of the effective diffusivity of an IgG polyclonal antibody both in water and in tumor tissue, we deduce that the diffusivity of this molecule in the interstitium is one-tenth to one-twentieth its diffusivity in water. We also conclude that exclusion of molecules from cells (an effect independent of molecular weight) contributes as much as interstitial hindrance to the reduction of effective diffusivity, for small interstitial volume fractions (around 20%). This suggests that the increase in the rate of delivery to tissues resulting from the use of smaller molecular-weight molecules (such as antibody fragments or bifunctional antibodies) may be less than expected.

Animals↗