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Biomedical subjects

S L Curry

Publications and source records attributed to S L Curry.

45 records · Page 3Linked to original sources

Malignant teratoma of the ovary: prognostic factors and treatment.

A series of 25 patients with malignant teratoma of the ovary is presented. In 56%, diagnosis was made before the age of 20; none had bilateral tumors, and 52% were in Stage I at the time of the original diagnosis. Treatment with operation followed by irradiation or single-agent chemotherapy was ineffective; there were no survivors in eight patients treated with either of these regimens. However, combination chemotherapy with vincristine, actinomycin D, and cyclophosphamide used postoperatively appears to be more effective since 10 to 12 patients who were treated with this method are surviving. Histologic grade appears to have questionable prognostic significance.

Adolescent↗

Fertility after cryosurgery of the cervix.

Fertility in patients following cryosurgery of the cervix was evaluated in 412 women. Cryosurgery does not appear to have any effect on subsequent fertility when compared with the general population.

Adult↗

Hydatidiform mole: diagnosis, management, and long-term followup of 347 patients.

This report concerns 347 patients with primary hydatidiform moles studied during the first 6 years (1966-1972) of operation of the Southeastern Regional Trophoblastic Disease Center. Aside from a decreased incidence, molar pregnancy in the United States follows a pattern similar to that elsewhere in the world. Abnormal bleeding is the key to early diagnosis, and the frequent use of sensitive HCG assays is the key to proper followup. Twenty percent of patients with hydatidiform moles can be expected to develop subsequent malignant sequelae. Bilateral ovarian enlargement and/or a large-for-dates- uterus should alert the physician to a greater potential for this outcome. Spontaneous elimination of HCG from the circulation following moler pregnancy, as indicated by sensitive assay, would predict a benign postmolar course; no patient in the current series who once achieved undetectable levels of HCG developed malignant trophoblastic disease.

Abortion, Induced↗

Obesity-related complications of pregnancy vary by race.

OBJECTIVE: To evaluate racial effects on obstetric complications in obese gravidas. METHODS: The obstetric database was reviewed for the period 6/1/94 to 3/31/97. All clinic patients delivering singletons were included. Obesity was defined as a body mass index (BMI) of 29 kg/m2 or more, or a pre-pregnancy weight of 200 pounds or more. Complications studied included hypertension, diabetes, cesarean delivery, and fetal macrosomia. RESULTS: Of 2,424 eligible subjects, 168 were obese (6.9%). Obese patients had higher rates of chronic hypertension and pregestational diabetes, as well as increased rates of preeclampsia, gestational diabetes, fetal macrosomia, cesarean delivery, and operative vaginal delivery compared to nonobese patients. Of the obese patients, 105 (63%) were Hispanic, 39 (23%) were African American, and 24 (14%) were White; no Asian or Mixed/Other patients were obese. Mean BMIs of the obese subgroups did not differ (P = 0.14), but prepregnancy weights were greater in Whites than Hispanics (P < 0.002). Obese Hispanics had an increased rate of gestational diabetes (P = 0.04) and of infant weight > or =4,500 g (P =.03). Obese Hispanic and African American women were more likely than obese Whites to deliver by cesarean (P = 0.03). CONCLUSION: Racial differences affect the complication rates in obese gravidas, and may influence prenatal counseling and pregnancy management.

Adult↗