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Biomedical subjects

S L Diaz

Publications and source records attributed to S L Diaz.

3 recordsLinked to original sources
PubMed2005

Efficacy of fipronil in the treatment of pediculosis in laboratory rats.

As parasitized rodents are not desirable experimental objects, it is important to maintain parasite-free laboratory rodent colonies. Faced with the task of eliminating pediculosis from a conventional laboratory rat colony whose individuals were intended to be used in scientific research, a drug treatment was needed which did not, or minimally, interfere with experimental results. Fipronil, a GABA(A) antagonist, is an effective drug against lice, fleas and mites currently used in domestic species. Fipronil is not absorbed, has a wide safety margin and is topically applied. The aim of this study was to treat an infected colony with Frontline Spray (0.25%-w/v-fipronil) in order to evaluate its efficacy against lice. Rats were sprayed with Frontline only once. Special procedures to prevent cross-contamination between cages were not used. Neither lice nor nits were found during any post-treatment examination. In addition, no complications were reported by any researcher after using the treated rats in their experiments. The results of this study demonstrate that fipronil in topical formulations is effective for treatment and control of sucking and biting lice infestations on laboratory rats.

Administration, Topical↗
PubMed2001

Lack of sex-related differences in the prevention by baclofen of the morphine withdrawal syndrome in mice.

In previous studies we have demonstrated a possible interaction between the GABAergic and opioid systems involved in the antinociceptive effect of the GABA(B) agonist, baclofen (BAC). On the other hand, sex differences have been observed for the antinociceptive effect of morphine (MOR). In the present study, we analyzed sex-related differences in the MOR abstinence syndrome and its prevention with BAC. Prepubertal male and female Swiss-Webster albino mice (27-33 g) were rendered dependent by intraperitoneal (i.p.) injection of MOR (2, 4 and 8 mg/kg), twice daily for 9 days. On the tenth day the dependent animals were divided into two groups: one received naloxone (NAL) (6 mg/kg, i.p.) 60 min after the last dose of MOR, to precipitate the abstinence syndrome; the other group received BAC (2 mg/kg, i.p.) followed by NAL (6 mg/kg, i.p.), injected 30 and 60 min after the last dose of MOR, respectively. Behavioral signs were recorded in the open field for 30 min. Although there were sex differences in the MOR withdrawal syndrome, we found a lack of sex differences in the prevention of the MOR abstinence syndrome by BAC.

Analgesics, Opioid↗