Biomedical subjects

S L Iagud

Publications and source records attributed to S L Iagud.

9 recordsLinked to original sources

PubMed1981

[Formation and persistence of L-variants of Salmonella typhi in experimental typhoid and in carriers].

The possibility of the induction and persistence of S. typhi L-forms in the process of experimental typhoid infection and carriership has been studied in rabbits. This study has revealed that the process of L-transformation leading to the appearance of the imbalanced growth forms and unstable L-forms of S. typhi in the organism of the animals infected with S. typhi culture may occur under the conditions of carriership. Such changed forms can be detected in the organism of the animals 18 months after the primary infection.

Animals↗

PubMed1981

[Salmonella typhi L-transformation process in in vivo experiments using diffusion chambers].

The process of L-transformation of S. typhi was studied under conditions of diffusion chambers implanted into the abdominal cavity of rabbits with different immunological status. The process of L-transformation of S. typhi in vivo was induced by the action of humoral immunity factors. No unbalanced growth forms and L-forms of S. typhi were found to appear in the organism of nonimmune animals.

Animals↗

PubMed1975

[Study of the process of interaction of the causative agent with the cells of the body and with a macrophage culture in experimental typhoid infection and carrier state].

Experiments were conducted on 117 rabbits and cells of the macrophage cultures in vitro by the methods of clinico-laboratory, quantitative microbiological, immunological, electron microscopic and microcinematographic examination; a study was made of the interaction of the typhoid causative agent with the cells of the organism and the macrophage cultures and also of some aspects of the immune response during acute typhoid infection and carrier state. Infection was modelled by the enteral, subconjunctival and intrabonemarrow infection with 24-hour culture of the typhoid bacillus (strain Ty2 4446). Experiments demonstrated that structural reconstruction of both the causative agent and of the cells of the organism, of the culture macrophages and their organoids occurred in the course of the first hour after the infection. Homogenates of the lymphoid and myeloid tissues and also of the macrophages and polymorphonuclears possessed bactericidal activity against S. typhi. The degree of this activity largely depended on the pH of the medium. It was also shown that under conditions of the macrophage culture sodium aside inhibited the bactericidal activity of macrophages obtained from the intact and immune animals.

Acute Disease↗

PubMed1973