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Biomedical subjects

S L Malhotra

Publications and source records attributed to S L Malhotra.

At least 19 recordsLinked to original sources
PubMed1993

The thesis of the alkaline milieu in oncology: a review.

An alkaline milieu is a common factor in some carcinomas of the oropharynx and oesophagus, the stomach, the bronchus, the cervix and the large bowel. The hypothesis is advanced that a change to an alkaline pH enhances the mitotic activity of mucous cells and that this change can be often avoided by alterations in diet and habit.

Colonic Neoplasms↗
PubMed1982

Secretin, glucagon, insulin-antibodies, islet-cell exhaustion and diabetes mellitus : a hypothesis.

There are many studies that show that important and interesting differences exist in the patterns of diabetes mellitus, not only between countries but from group to group in the same country. Such big differences suggest the causes may be environmental, most of which are dietary and, therefore, preventable. In these dietary factors it is perhaps the pattern of eating, the presence or absence of cellulose, roughage and vegetable fibre, milk and fermented milk products such as yoghurt, which are of crucial importance. There is a quicker rise of blood glucose in the case of "non-masticatory-roughage-poor" dietary regimens as compared with "masticatory" milk, milk-products and roughage-rich regimens on account of faster gastric emptying in the former and slower gastric emptying in the latter. The hyperchlorhydria caused by fibre-poor non-masticatory meals produces an instantaneous secretin-release which results in hyperinsulinism. Such "sucrose-induced hyperinsulinism" leads to formation of insulin antibodies. Diabetes is caused by this excessive inactivation of insulin by antibodies, brought about by dietary factors, setting up the vicious cycle of hurried meals - hyperchlorhydria and secretin resulting in instantaneous insulin-release - neoglucogenesis more insulin-release - insulin antibodies and a further secretion of insulin - insulin antagonism - islet cell exhaustion - diabetes mellitus. There is evidence of an alternative mechanism in which diabetes appears to be caused by interference with insulin-release even though islets manufacture insulin normally.

Blood Glucose↗
PubMed1982

Faecal urobilinogen levels and pH of stools in population groups with different incidence of cancer of the colon, and their possible role in its aetiology.

Mean faecal urobilinogen levels and the pH of stools were both found to be higher in subjects from a population group at high risk of developing cancer of the colon than in subjects matched for age, sex and socioeconomic status from a low-risk population group. An alkaline reaction of the colon contents seems to have a tumorigenic effect by a direct action on the mucus of the mucous cells. An acidic reaction, on the other hand, appears to be protective. These differences are dependent on the patterns of diet and manner of eating. Proper mastication of food, roughage, cellulose and vegetable fibre, and short-chain fatty acids of milk and fermented milk products in the diet appear to be protective.

Adult↗
PubMed1978

A comparison of unrefined wheat and rice diets in the management of duodenal ulcer.

Twenty-one chronic duodenal ulcer patients in a rice-eating area were put on to an unrefined wheat diet and twenty-one continued on their previous rice diet. After 5 years only 14% of the first group had had relapses compared with 81% of the second group. A similar 5-year relapse rate (80%) was obtained in a group of thirty patients from another area with a more varied rice diet. The author attributes this difference to the increased mastication required by the unrefined wheat diet, which is associated with an increase in saliva, lower stomach acidity and reduced bile output.

Adult↗