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Biomedical subjects

S L McDowell

Publications and source records attributed to S L McDowell.

10 recordsLinked to original sources
PubMed1997

The effects of salmeterol on power output in nonasthmatic athletes.

BACKGROUND: Salmeterol xinafoate is a new aerosol inhalant that is used in the treatment of asthma. It is currently banned by the International Olympic Committee because of the concern that it may lend an unfair competitive advantage to the user. OBJECTIVE: The purpose of this study was to determine whether salmeterol improves short-term anaerobic performance in elite nonasthmatic track cyclists. METHODS: Eleven elite track cyclists volunteered to perform a 30-second all-out cycle ergometer test 3 hours after receiving either 42 micrograms of salmeterol xinafoate or placebo applied in a double-blind crossover procedure. During the ergometer test, peak power output, total work, time to peak power, and percent fatigue (decline in power output) were measured. Pulmonary measurements were also taken before and at various time points after inhalation and the ergometer test. A methacholine challenge was administered to each subject before participation in the study to ensure that none of the subjects had any reactive airway diseases. RESULTS: There were no significant differences (p > 0.05) between the placebo and salmeterol trials for peak power output, total work performed during the 30-second test, percent fatigue, and time to peak power. No differences between trials were observed for the pulmonary function test variables at any of the time points. Blood lactate concentrations before and after administration of drug or placebo were also not significantly different between trials. Additionally, salmeterol did not affect the maximal heart rate achieved during the test as compared with the placebo. CONCLUSIONS: Short-term salmeterol use within the prescribed dosage was not shown to increase short-term power output in nonasthmatic cyclists.

Adult↗
PubMed1995

Role of psychological stress in cortisol recovery from exhaustive exercise among elite athletes.

Life-event stress (LES) was used to classify elite athletes (n = 39) into high- and low-LES groups. A repeated measures analysis of variance revealed higher cortisol concentration after a graded exercise lest among the high-LES group relative to the low-LES group, which was maintained for up to 20 hr. Subsequent prospective analyses further indicated that high-LES athletes were more likely lo he symptomatic than low-LES athletes and that elevated cortisol level was positively correlated with symptomatology. To the extent that cortisol is a marker of exercise recovery in competitive athletes. our results suggest that chronic stress prolongs the recovery process, which may potentially widen a window of susceptibility for illness and injury among competitive athletes.

Journal Article↗
PubMed1992

The effect of exercise training on salivary immunoglobulin A and cortisol responses to maximal exercise.

The salivary immunoglobulin A (s-IgA) and cortisol responses to maximal exercise were examined in 24 adult males (X +/- SD; 22.1 +/- 3.0 yrs) before and after 10 weeks of run training. The subjects performed an incremental treadmill test to exhaustion and were randomly assigned to one of three groups: control (CON; n = 5), low intensity training (LO; n = 8), or high intensity training (HI; n = 11). Following the ten weeks of training, the subjects performed a second maximal treadmill test. Saliva samples were collected before, as well as immediately and 1 hr following each of the maximal treadmill tests and were analyzed for s-IgA and salivary cortisol. Maximal oxygen consumption (VO2max) increased significantly (p < 0.05) in the LO and HI groups but remained unchanged in the CON group. The s-IgA levels decreased significantly (p < 0.05) immediately post-exercise but returned to pre-exercise levels by one hour recovery. In addition, s-IgA and cortisol levels were not significantly (p > 0.05) correlated at any of the sampling times. These findings indicated that the s-IgA response to maximal exercise was unaffected by moderate (70% of VO2 max) to heavy (86% of VO2max) training (designed to develop cardiorespiratory fitness in healthy non-athletic adults) and independent of salivary cortisol.

Adult↗
PubMed1992

The effect of exhaustive exercise on salivary immunoglobulin A.

The purpose of this study was to examine salivary immunoglobulin A (s-IgA) responses to exhaustive exercise. Twenty-nine, college age (means +/- SD = 21.45 +/- 3.1 yrs; range 18-29 yrs) moderately active males (running < 10 miles per week) performed an incremental treadmill test to exhaustion. Unstimulated salivary samples, collected before as well as immediately and one hour following the test, were analyzed for s-IgA using an enzyme-linked immunosorbent assay (ELISA). Mean s-IgA levels decreased significantly (24.4%, p < 0.05) immediately following the maximal test, and remained depressed (16.9%) one hour after the test. Of the 29 subjects, five exhibited an increase (range = 1.3 to 53.3%) in s-IgA following the exercise bout. The results of this study suggest that exhaustive exercise may temporarily reduce salivary IgA levels.

Adolescent↗
PubMed1992

The relationship between anaerobic running capacity and peak plasma lactate.

The purpose of this study was to examine the relationship between anaerobic running capacity and peak plasma lactate. Twelve adult males (mean age +/- SD = 21.9 +/- 1.2 yrs) performed a critical velocity test from which anaerobic running capacity was determined and a maximal treadmill running test from which peak plasma lactate was determined from post-exercise blood samples taken at one minute intervals. The results indicated that anaerobic running capacity (mean +/- SD = 0.18 +/- 0.04 km) was not significantly (r = -0.06, p greater than 0.05) correlated with peak plasma lactate (9.3 +/- 1.8 mM). These findings do not support anaerobic running capacity as an indirect indicator of anaerobic capabilities.

Adult↗
PubMed1991

The effect of exercise intensity and duration on salivary immunoglobulin A.

Two experiments were performed to examine salivary immunoglobulin A (s-IgA) responses to varying levels of exercise intensity and duration. For experiment 1, 9 college men (mean age, SD = 23.56, 1.64 years) completed treadmill runs of 15, 30, and 45 min at approximately 60% of maximum oxygen consumption (VO2max). For experiment 2, 9 other college men (mean age, SD = 23.67, 2.0 years) ran for 20 min at approximately 50, 65 and 80% of VO2max. Unstimulated salivary samples were collected before, and immediately, 1 and 2 h after the exercise. Samples were assayed for s-IgA using an enzyme-linked immunosorbent assay. Mean s-IgA levels did not change significantly (P greater than 0.05) at any of the post-exercise collection times when compared to pre-exercise levels. The results of this investigation indicated that running at intensities of 50-80% of VO2max and for durations of 15-45 min did not affect s-IgA levels.

Adult↗
PubMed1991

Physiological responses at the fatigue threshold.

The purpose of this investigation was to determine the oxygen consumption, heart rate and plasma lactate responses at the fatigue threshold (FT) and estimate the length of time the FT could be maintained. Ten adult males (mean age +/- SD = 21.1 +/- 1.3 yrs) volunteered to perform a maximal treadmill test and FT test. During the maximal test, VO2 heart rate and plasma lactate measurements were taken. The results of the investigation indicated that the FT (14.0 +/- 1.2 km.hr-1, 197 +/- 8 bpm; 47.5 +/- 5.7 ml/kg.min-1, 5.4 +/- 1.3 mM) was very close to a maximal effort (VO2max = 14.4 +/- 1.2 km.hr-1, 203 +/- 10 bpm; 49.5 +/- 6.1 ml/kg.min-1, 7.4 +/- 2.1 mM) and could be maintained for only 0.16 to 0.28 hrs. These findings do not support the validity of the FT as a measure of the maximal running velocity that can be continued for an extended period of time without exhaustion.

Adult↗
PubMed1989

Validity of anthropometric estimations of body composition in high school wrestlers.

The purpose of this study was to determine the validity of 23 anthropometric equations for estimating body composition and minimal wrestling weight in high school wrestlers. A total of 409 high school wrestlers (M age +/- SD = 16.42 +/- 1.03 yrs) volunteered for this study. Twenty-three anthropometric measures including eight skinfolds, nine circumferences, and six diameters were obtained from each subject. The mean body density, determined from underwater weighing, was 1.0748 +/- 0.0100 g.cm-3. The crossvalidation analyses indicated that the quadratic skinfold equation of Lohman resulted in the most accurate estimation of body density. The total error, constant error, standard error of estimate, and r for this equation were 0.0077 g.cm-3, -0.0003 g.cm-3, 0.0076 g.cm-3 and .65, respectively. Furthermore, the results of this investigation indicated that the minimal wrestling weight equations of Tcheng and Tipton resulted in total error values (5.54 to 6.06 kg) which were too large to be of practical use for high school wrestlers.

Adolescent↗
PubMed1989

Validity and intertester error of anthropometric estimations of body density.

The purposes of this study were to evaluate the intertester error in anthropometry and its effect on estimations of actual body density (ABD), as well as to assess the validity of predicted body density (PBD) from selected anthropometric equation. Sixteen adult males X +/- SD = 21.98 +/- 1.65 years) volunteered to be measured by three experienced and reliable testers at eight circumference, two diameter, and eight skinfold sites as well as by underwater weighing. Eighteen commonly used anthropometric equations which predict body density were selected for evaluation. Repeated measures ANOVA with Tukey post-hoc comparisons were used to determine differences between testers for each anthropometric measure and the PBD values, as well as between the PBD values and ABD. There were significant (p less than 0.01) differences between testers for all anthropometric measures except bi-iliac diameter and hips circumference. However, the magnitude of the differences between testers were considered to be quite small and of no practical concern. There were significant differences among the PBD values and ABD for all equations except the base 10 logarithmic transformations of Durnin and Womersley. Seven of the equations, however, resulted in a constant error of less than or equal to 0.0085 g.ml-1. Overall, there was no single anthropometric equation which satisfied all of the cross-validation criteria suggested by previous investigators, however the linear equation of Forsyth and Sinning which included the scapular and abdominal skinfolds, as well as the bitrochanteric diameter resulted in an extremely small constant error (0.0024 g.ml-1) and an appropriate standard deviation of the PBD values (0.0127 g.ml-1).

Adult↗