Biomedical subjects

S L Sandford

Publications and source records attributed to S L Sandford.

5 recordsLinked to original sources

PubMed1996

Neuropsychological impairment in a patient with a normal liver and long-standing portacaval anastomosis: studies obtained before and after liver transplantation.

A case report of the neuropsychiatric consequence of long-standing portal caval shunting in a man without intrinsic liver disease is described. Because of his neuropsychiatric status he underwent liver transplantation. Over the succeeding 8 months he had progressive improvement in his neuropsychiatric performance. These data document the adverse effects of portal caval shunting on neuropsychiatric performance in the absence of intrinsic liver disease as well as their reversibility with shunt closure.

Humans↗

PubMed1989

Hepatic injury correlates with neuropsychologic impairment.

Five liver injury measures (albumin, prothrombin time, gamma globulin, indocyanine green clearance and serum ammonia) were correlated with neuropsychologic test performance in a group of 79 nonalcoholic cirrhotic patients. Employing linear regression analysis techniques revealed that these five measures, particularly albumin and prothrombin time, could explain a significant amount of the variance on neuropsychological tests. The results indicate that functional liver status, even where there is no overt evidence of hepatic encephalopathy, is related to cognitive capacity.

Adult↗

PubMed1987

Sensory information processing in patients with nonalcoholic cirrhosis. Short-latency visual, auditory, and somatosensory event-related potentials.

Visual, auditory and brainstem event-related potentials were obtained from patients with hepatocellular and cholestatic disease and a control group of normal subjects. The results did not reveal systematic neurophysiologic disturbances in persons with well compensated cirrhosis. It is concluded that short-latency event-related potentials are rather insensitive for detecting subclinical hepatic encephalopathy.

Adult↗

PubMed1987

Relationship between hepatic injury status and event related potentials.

Visual, auditory and somatosensory event related potentials were recorded from 58 patients with chronic nonalcoholic liver disease. The results of this study indicate that a significant, although somewhat modest, amount of variance on brainstem auditory, pattern visual and somatosensory ERP latency can be predicted by routinely obtained liver functional measures, albumin, prothrombin time, fasting ammonia level, globulin and especially indocyanine green clearance. Moreover, these associations are present in persons who are not overtly encephalopathic, underscoring the sensitivity of neurophysiologic measurement for detecting hepatic encephalopathy concomitant to only moderate severity of hepatic injury.

Adult↗

PubMed1985

A multi-modal questionnaire for stress.

This paper presents data regarding the Strain Questionnaire (SQ), a 48-item scale designed to measure self-report levels of behavioral, cognitive, and physical stress complaints. A heterogeneous sample of 412 adults completed the SQ, and correlational, reliability, factor analytic and validity data are reported. Results suggest that the items reflect a wide range of content which show high internal consistency on each of the three subscales and the total SQ. Test-retest reliability demonstrated satisfactory temporal stability of the scales. Factor analysis of the SQ produced eleven orthogonal factors. The most salient factor was "cognitive/behavioral strain" which highlights the necessity for including these variables in self-report surveys of stress. Future research needs are also discussed.

Adolescent↗