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Biomedical subjects

S L Willis

Publications and source records attributed to S L Willis.

At least 19 recordsLinked to original sources

The use of rhodamine 6G and fluorescence microscopy in the evaluation of phospholipid-based polymeric biomaterials.

A technique is described that allows the staining and subsequent visualization of polymers that contain the phosphorylcholine (PC) group. These materials are useful as bulk materials or coatings for the fabrication of medical devices. The staining method employs rhodamine 6G, which can be simply and rapidly applied to the polymer coating and imaged using fluorescence microscopy. The specificity of the staining for the PC polymers makes this technique suitable for the evaluation of a wide range of substrates and provides qualitative information on coating uniformity, coverage and morphology. It can be used to examine the durability of, and defects in, the coating. Statistical analysis of the fluorescent intensity by measuring the pixel value during imaging can allow for the method to be used as a quality control tool.

Biocompatible Materials↗

ACTIVE: a cognitive intervention trial to promote independence in older adults.

The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial is a randomized, controlled, single-masked trial designed to determine whether cognitive training interventions (memory, reasoning, and speed of information processing), which have previously been found to be successful at improving mental abilities under laboratory or small-scale field conditions, can affect cognitively based measures of daily functioning. Enrollment began during 1998; 2-year follow-up will be completed by January 2002. Primary outcomes focus on measures of cognitively demanding everyday functioning, including financial management, food preparation, medication use, and driving. Secondary outcomes include health-related quality of life, mobility, and health-service utilization. Trial participants (n = 2832) are aged 65 and over, and at entry into the trial, did not have significant cognitive, physical, or functional decline. Because of its size and the carefully developed rigor, ACTIVE may serve as a guide for future behavioral medicine trials of this nature.

Activities of Daily Living↗

Cognitive and sociodemographic risk factors for mortality in the Seattle Longitudinal Study.

The relationship between cognitive function and survivorship was examined in a community-dwelling sample. Survival analysis was used to examine how level and change in intellectual functioning, verbal memory, perceptual speed, and psychomotor speed were related to mortality in a sample of 601 individuals who subsequently died (decedents; n = 342 men; n = 259 women; M = 73.81 years of age) and a control group of 609 survivors (n = 296 men; n = 313 women; M = 71.96). The sample of survivors was selected to be of similar age and to have a similar level of education as the decedents. Individuals in the lowest 25th percentile of performance (crystallized abilities, visualization abilities, verbal memory, and perceptual and psychomotor speed) had a significant risk for subsequent mortality compared to individuals in the highest 25th percentile. However, after adjusting for demographic variables and psychomotor speed, only perceptual speed remained a significant risk factor for mortality. Significant 7-year declines (lowest 25th percentile) in measurements of Verbal Meaning, Spatial Ability, Reasoning Ability, and Psychomotor Speed were risk factors for subsequent mortality relative to those who had the least amount of decline. The relationship between mortality and cognitive function tended to be a specific rather than a pervasive phenomenon, even after adjusting for sociodemographic factors and psychomotor speed. Decrease in cognitive performance tended to be a better predictor of subsequent mortality than was the level of cognitive performance.

Adult↗

Everyday problem solving among individuals with Alzheimer's disease.

Loss of functioning on complex tasks of daily living is an early indicator of dementia. The performance of 65 older adults with mild to moderate levels of Alzheimer's disease was examined on the Everyday Problems Test for the Cognitively Challenged Elderly (EPCCE), self-report inventories of functional performance, and a broad battery of clinical and neuropsychological measures. The EPCCE was designed to assess older adults on a set of complex tasks of daily living that involved not only global cognitive processes, but also higher-order executive functions. Participants solved an average of 45% of EPCCE tasks with significant differences in scores by disease severity. Performance was significantly related to global cognitive functioning and disease severity, and in particular to executive functions. Significant additional variance was accounted for by these executive functions beyond the variance accounted for by global cognitive measures.

Activities of Daily Living↗

Everyday cognitive competence in elderly persons: conceptual issues and empirical findings.

This article focuses on everyday cognitive competence as a critical aspect of functional health. Everyday cognitive competence is defined as the ability to perform adequately those cognitively complex tasks considered essential for living on one's own in this society. A major challenge for those involved in assessment and judgment of competence is to define the critical domains of functional abilities associated with living independently. Prior research on the instrumental activities of daily living (IADLs) may be particularly useful. Findings from our research on a measure assessing everyday cognitive competence within each of the IADL domains are presented. Elderly persons' performance on the measure of everyday cognition relate to behavioral observations of those subjects performing similar activities in their home and to self and spousal IADL ratings. Seven-year longitudinal data indicate that there is relatively modest decline in performance on cognitively complex everyday tasks during the 60s, but that steeper patterns of normative decline are found in the late 70s and 80s.

Activities of Daily Living↗

Similarity in married couples: a longitudinal study of mental abilities and rigidity-flexibility.

Longitudinal changes in couple similarity on the Primary Mental Abilities and the Test of Behavioral Rigidity were studied over 7-year intervals from 1956 to 1984 in 169 couples from the Seattle Longitudinal Study. Positive, initial intraclass spousal correlations were significant for verbal meaning, inductive reasoning, word fluency, educational aptitude, intellectual aptitude, attitudinal flexibility, psychomotor speed, and social responsibility, as well as age and education. After age and education had been controlled, significant increases in spousal similarity were found for verbal meaning and intellectual ability over 14 years and for attitudinal flexibility over 21 years. The higher functioning spouses' word fluency influenced the lower functioning spouses' verbal meaning and word fluency over time. Couples who became more similar over time involved husbands in higher occupations and wives with fewer changes in profession.

Adult↗

Dimensionality of everyday problem solving in older adults.

This study investigated individual differences in older adults' everyday problem-solving performance using 3 instruments. Past research, typically using only single measures, has yielded a multitude of findings regarding age effects in everyday problem solving. The present sample consisted of 111 older adults (44 men, 67 women) who ranged in age from 68 to 94 years. Confirmatory factor analyses revealed that, within each of the 3 instruments, subscales representing particular content domains could be reliably identified. There was, however, little relation between the different instruments, and the measures also differed in their relation with chronological age. These results support the view that everyday problem-solving competence is a multidimensional construct, of which previous investigations may only have studied particular dimensions.

Activities of Daily Living↗

Everyday problem solving in older adults: observational assessment and cognitive correlates.

Older adults' ability to solve practical problems in 3 domains of daily living was assessed using a new measure of everyday problem solving, the Observed Tasks of Daily Living (OTDL). Findings showed that the OTDL formed internally consistent scales representing 3 distinct factors of everyday problem solving. Moreover, the OTDL showed convergent validity with related scales of a paper-and-pencil test. Older adults' performance on the OTDL was significantly correlated with their scores on measures of basic mental abilities. Path analysis showed that age affected older adults' performance on the OTDL directly and indirectly via cognitive abilities. Participants' education and health affected their everyday competence indirectly through cognitive abilities. The effects of perceptual speed and memory span were mediated by fluid and crystallized intelligence.

Activities of Daily Living↗

Perceived intellectual performance change over seven years.

Actual and perceived change in intellectual performance over seven years was examined in a sample of 837 participants in the Seattle Longitudinal Study who took five subtests of Thurstone's Primary Mental Abilities (PMA) test in 1977 and 1984. In 1984 participants rated perceived change in intellectual performance from 1977 to 1984. Participants were categorized, based on their actual performance, into those who maintained earlier performance level, significantly increased their performance, or declined in performance. A typology linking actual and perceived change in performance was created: Realists (those who accurately estimated change in their performance); Optimists (those who oveestimated positive change); and Pessimists (those who overestimated negative change). Classification of participants varied across abilities. Women were more likely to be pessimists on Spatial Orientation than men. Older individuals were more likely to be pessimists on Verbal Meaning and Inductive Reasoning Abilities and to be realists on Number ability compared to younger participants.

Adult↗

Age difference patterns of psychometric intelligence in adulthood: generalizability within and across ability domains.

Cross-sectional data from the 5th (1984) wave of the Seattle Longitudinal Study are reported with regard to the generalizability of age differences in psychometric intelligence within and across ability domains. Ss were 1,628 community-dwelling individuals drawn from a Pacific Northwest health maintenance organization. Age difference patterns of 9 groups with mean ages from 29 to 88 years are examined for the ability domains of verbal ability, spatial orientation, inductive reasoning, numeric ability, verbal memory, and perceptual speed. Each ability is marked by 3 or 4 observed variables.

Adult↗

Influence of direct computer experience on older adults' attitudes toward computers.

This research examined whether older adults' attitudes toward computers became more positive as a function of computer experience. The sample comprised 101 community-dwelling older adults aged 57 to 87. The intervention involved a 2-week computer training program in which subjects learned to use a desktop publishing software program. A multidimensional computer attitude measure was used to assess differential attitude change and maintenance of change following training. The results indicated that older adults' computer attitudes are modifiable and that direct computer experience is an effective means of change. Attitude change as a function of training was found for the attitude dimensions targeted by the intervention program: computer comfort and efficacy. In addition, maintenance of attitude change was established for at least two weeks following training.

Aged↗

Relationship between rigidity-flexibility and cognitive abilities in adulthood.

The interrelationship of measures of rigidity-flexibility and of psychometric intelligence is examined. The latent factors of Attitudinal Flexibility, Motor-Cognitive Flexibility, and Psychomotor Speed are derived from the Test of Behavioral Rigidity, and factors of Inductive Reasoning, Spatial Orientation, Verbal Ability, Numeric Ability, Verbal Memory, and Perceptual Speed are derived from the Thurstone Primary Mental Abilities Test and the Educational Testing Service Kit of Factor-Referenced Tests. The data base in this study comes from the fifth wave of the Seattle Longitudinal Study (N = 1,628; age range, 22-95 years). The Rigidity-Flexibility factors were found to be independent of the cognitive domain. Also, longitudinal stability of the factor structure of the rigidity-flexibility domain was confirmed for 837 participants tested in both 1977 and 1984.

Adult↗

Adult personality and psychomotor performance: cross-sectional and longitudinal analyses.

Results are presented from cross-sectional and longitudinal analyses of data from the Test of Behavioral Rigidity for 3,442 subjects over the age range from 22 to 84 years. Data are presented on the Behavioral Flexibility, Attitudinal Flexibility, and Social Responsibility questionnaire scales, as well as on performance score measures indexing Associational Flexibility, Instructional Set Flexibility, Copying Speed, and Associational Speed. Data on these scales were obtained for 5 samples examined 7 years apart (1956, 1963, 1970, 1977, and 1984). These data permit analyses of birth cohort differences and rate of change within the same individuals, as well as successive samples drawn from the same cohort over as long as 28-year periods. Results of the analyses confirm the presence of substantial generational differences, with generally only limited change over time within cohorts.

Adult↗

Natural cohorts: family similarity in adult cognition.

We now return to the sets of hypotheses formulated in the introductory section to explore how the findings reported above bear on these propositions. Our first hypothesis dealt with whether family similarity could be observed in adulthood and whether there were differing ability patterns in such similarity. Significant family similarities were observed for our total sample for all ability measures, except Perceptual Speed, and for the cognitive style measures. The magnitude of correlations for the ability measures are comparable for those found between young adults and their children (DeFries et al., 1976). Similar to the DeFries study, we also found differences in resemblance across subsets. For example, same gender pairs showed higher correlations on Verbal Meaning, Number, and Word Fluency but opposite-gender pairs on Spatial Orientation, Inductive Reasoning, and Motor-Cognitive Flexibility. Also, greater similarity was found between mother-offspring pairs than father-offspring pairs on Inductive Reasoning and Psychomotor Speed. Moreover, higher parent-offspring correlations were found for daughters than for sons, suggesting at least the possibility that females may experience greater shared environmental influences than males. Our first hypothesis also argued for the possible effect of early shared environment upon offspring performance on Verbal Meaning and Word Fluency. After age adjustment, these were indeed the abilities that showed the highest parent-offspring similarity. Our second hypothesis proposed that if shared environmental influences are relatively unimportant in adulthood, then similarity within parent-offspring pairs should remain reasonably constant in adulthood across time and age. Our examination of this issue with a longitudinal sample ranging over a 21-year period strongly supports this proposition for all of those variables that displayed significant parent-offspring correlations. Indeed, parent-offspring correlations measured at approximately the same age of parent and offspring and when those ages were 20 years apart had similar magnitudes. The third hypothesis asked whether family similarity would decrease with age because of the increasing amount of nonnormative, nonshared environment expected as adult life progresses. Counterintuitively, no such decrease in similarity could be observed. Indeed, for two variables there was evidence for increasing similarity as a function of offspring age. This finding makes good sense for our Perceptual Speed variable. Most of our younger offspring typically have not yet experienced age-related decline on this variable, whereas some of their parents have. Both older offspring and parents may have experienced sufficient decline so that once again their observed similarity is increased.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗

The relationship between prior functioning on cognitive and personality dimensions and subject attrition in longitudinal research.

This study compared the intellectual and personality functioning of continuing participants in a longitudinal study with individuals who were lost from the panel after at least 7 years of involvement. Based on their reason for discontinuation, participants who were lost to the panel were categorized into three attrition groups: deceased, ill, and voluntary dropouts. When the performance of these groups prior to leaving the study was compared with that of the continuing participants, no general differences were found. However, specific differences were revealed, particularly on crystallized-type intellectual abilities and the personality factors. Participants who were lost due to illness or death had functioned at the lowest levels of the four groups prior to attrition. These effects varied by age. In late middle age, ill participants functioned at the lowest levels, whereas in old age, participants who subsequently died scored lowest of the four groups prior to attrition. Individuals who had voluntarily discontinued participation in the study most closely resembled the continuing participants, particularly in late middle age. The results indicate that performance effects associated with continued participation vary by age, the intelligence or personality factor being considered, and the reason for loss of the participant. Furthermore, they suggest that loss of participants from a longitudinal panel does not inevitably bias the validity of developmental findings.

Adult↗

Effects of cognitive training on primary mental ability structure.

We report results of the first empirical test, as far as we know, of the assumption of structural invariance of latent constructs from pretest to posttest in cognitive training research on the elderly. In all, 401 participants in the Seattle Longitudinal Study, over 62 years old, received a 5-hr test battery at pre- and posttest that included 16 ability tests, marking the five primary abilities of Spatial Orientation, Inductive Reasoning, Numerical Ability, Verbal Ability, and Perceptual Speed. A total of 229 of our subjects received 5 hr of individual training on either Spatial Orientation or Inductive Reasoning. Restricted factor analysis with the LISREL algorithm tested the hypothesis of measurement equivalence across test occasions, separately for the control subjects and for each of the training groups. When ability-specific cognitive training intervenes, no structural change is observed for abilities not subject to intervention. However, slight shifts occurred in the optimal regression weights for the different markers for the training target abilities.

Aged↗