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Biomedical subjects

S Lamperi

Publications and source records attributed to S Lamperi.

At least 37 records · Page 2Linked to original sources
PubMed1986

Effects of biofiltration versus hemofiltration in the treatment of chronic uremia.

Biofiltration (BF), a new depurative hemo-diafiltration employing a high efficiency membrane (acrylonitrile and metallylsulphonate of sodium) and reinfusion of 8-9 liters of fluid was tested as an alternative method to hemofiltration (HF). Sixteen uremic patients who showed circulatory instabilities during traditional hemodialysis (HD) were treated with HF (27 liters infused in postdilution), or BF (210 min/session) for 12 months. Low and middle molecular weight metabolites weekly clearances, calcium, phosphorus and bicarbonate serum levels in BF and HF showed no significant differences: in BF the incidence of symptomatic hypotension events and orthostatic changes of mean blood pressure were lower than in HD, but a little higher than in HF. Our results show that BF achieves satisfactory depuration of low and middle molecular weight metabolites in a shorter time than HF and an improvement of autonomic nervous system abnormalities is observed.

Acrylic Resins↗
PubMed1985

Erythroid progenitor growth in erythrocytosic transplanted patients.

In 55 patients who underwent renal transplantation, erythrocytosis (E) was observed in 6. In all patients, the growth of erythroid progenitors [burst-forming unit erythroid (BFU-e)], using mononuclear blood cells, was evaluated in in vitro cultures. The results showed a significant increase of serum erythropoietin (s-Ep) in erythrocytosis and in nonerythrocytosis patients with a subsequent decrease when hematocrit (Hct) and hemoglobin (Hb) reached high levels, showing a recovery of a feedback control system. Notwithstanding the diminution of s-Ep, six patients demonstrated further progressive rise of the Hct and Hb to a final state of E. The in vitro BFU-e cultures from these patients showed a noticeable sensitivity to progressively reduced doses of Ep and also the capacity to develop a few colonies when the medium was Ep-free. These results were not verified using peripheral blood depleted of monocyte and/or T lymphocyte cells. Therefore, in transplanted patients with erythrocytosis, it is possible that particular cellular interactions stimulate an early hyperproliferation of BFU-e with a greater Ep sensitivity and at least partly the capacity to grow also in the absence of Ep.

Adult↗
PubMed1985

T lymphocytes, monocytes and erythropoiesis disorders in chronic renal failure.

The T lymphocytes, OKT4-depleted T lymphocytes, monocytes, macrophages and the bone marrow early erythroid progenitor (BFU-E) interactions have been evaluated in normal subjects and in uremic patients in predialysis phase (PDP), on hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). In the same subjects the T-cell growth factor (TCGF) activity and the T-cell subset identification have also been assessed. The results show in uremic patients, particularly in the presence of reduced OKT4 subset and TCGF activity, a blockage of the interactions between immunocompetent and bone marrow cells which normally could stimulate early erythroid progenitor growth. Since this blockage is partially removed by CAPD, this may suggest a more efficient removal of an interaction inhibitor with CAPD than with other dialysis techniques. The mechanism by which such a material may act appears unclear, but it is possible to suppose an inhibiting activity on the production of TCGF by lympho-monocyte cells which under normal conditions could be considered as an early erythropoiesis regulatory factor.

Adult↗
PubMed1985

Polycythaemia is erythropoietin-independent after renal transplantation.

Serum erythropoietin increased in 55 patients after transplantation. The serum erythropoietin decreased when the haematocrit and haemoglobin reached high levels, indicating recovery of a feed-back control system. Despite the diminution of erythropoietin, six patients demonstrated a state of erythrocytosis while the in vitro cultures of BFU-e revealed high sensitivity to the reduced doses of erythropoietin, using monocyte-free T-lymphocyte-depleted peripheral blood. In polycythaemic transplanted patients it is possible that cellular interactions stimulate an early hyperproliferation of BFR-e with a greater erythropoietin sensitivity and a partial capacity to grow in the absence of erythropoietin.

Erythropoiesis↗
PubMed1984

CAPD and bone marrow cell-cell interaction abnormality in end stage renal disease.

In this research the early erythroid progenitor (BFU-E) growth has been observed in patients with chronic renal failure by studying in "in vitro" cultures the number of BFU-E developed per plate under various experimental conditions. Our results demonstrate that the BFU-E growth of uremic patients in the predialysis phase or on hemodialysis is suppressed both in basal conditions and with the addition of lympho-monocytes of normal subjects or CAPD patients to the "in vitro" cultures. In CAPD patients, on the contrary, the BFU-E growth appears near normal levels in basal conditions and is further more enhanced by adding the normal lympho-monocytes to the "in vitro" cultures. The above mentioned facts signify that in uremic patients both the abnormality of bone marrow and immunocompetent cells may be responsible for the suppressed BFU-E growth, while with CAPD the improvement of both systems allow a normalisation of erythropoiesis. Such a recovery with CAPD demonstrates the presence of an inhibitor material in uremia which is better depurated by this technique.

Adult↗
PubMed1983

Improvement of erythropoiesis in uremic patients on CAPD.

Chronic renal failure anemia noticeably improves only in patients who undergo CAPD treatment. In order to understand why it is so, the behaviour of some hematological parameters and the weekly clearances of creatinine and peak 7c1 were studied in the course of hemodialysis (HD) and CAPD. Our study shows that an improvement in hematological data is obtained in patients undergoing CAPD but not in those undergoing HD: this result is directly correlated with the increase of the peak 7c1 weekly clearance. Since the serum erythropoietin values are not modified, the improvement of the anemia appears to be related to the reduction of the biochemical abnormality of uremia using a better qualitative or quantitative depuration of bone marrow activity inhibitory material by CAPD.

Adult↗
PubMed1981

Gel-filtration on psoriasic and uremic serum and dialysis fluid.

In this search the serum and dialysis fluid of psoriasic patients in comparison with those of normal and uremic subjects have been evaluated by gel-filtration through a Sephadex G-15 column. The results showed a storage of the substances with various molecular weight in these patients. Particular attention was addressed to those with MW less than 1500 because they are not generally present in the normal subjects, decrease in the serum of psoriasic and uremic patients during the dialytic therapy, simultaneously with positive effects on the clinical symptomatology.

Blood Chemical Analysis↗
PubMed1979

Skin muscle biopsy in patients with various nephropathies.

Skin-muscle and kidney biopsy specimens were obtained from 43 patients with glomerulonephritis and from 5 normal subjects. 14 of the 43 patients had mesangial IgA nephropathy and in 12 the immunofluorescence study of skin-muscle biopsy showed IgA deposits. Ultrastructural research performed on 4 of these patients showed some electron-dense deposits on the walls of the muscular capillaries or in the perivascular connective tissue which could represent the immune aggregates. The remaining 29 patients had nonsystemic chronic glomerulonephritis with various immune deposits; only in 7 of these patients was the immunofluorescence study positive. The said study suggests that immunofluorescence examination of skin-muscle biopsy specimens could be diagnostically important.

Adolescent↗
PubMed1979

Effects of 1-alpha OH D3 therapy in uremic patients in conservative or dialytic treatment.

The effects of phosphate restriction and of 1 alpha OH D3 administration were investigated in patients with advanced chronic renal failure. Few modifications of the various biochemical parameters in the patients were achieved with the restriction of dietary phosphate while better results were obtained with 1 alpha OH D3 administration. In dialyzed patients the treatment with this drug resulted in a normalization in serum calcium and alkaline phosphatase levels and in a remarkable significant decline in plasma parathyroid hormone and a reduction in the bone disease associated with uremia. This treatment in dialyzed uremic patients could avoid the employment of higher dialysate calcium concentration potentially dangerous for postdialysis hypercalcemia with the risk of metastatic calcifications.

Adolescent↗