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Biomedical subjects

S Lanset

Publications and source records attributed to S Lanset.

7 recordsLinked to original sources

Studies on an isolated West Indies population (V): Genetic differentiation, evidence for founder effect and drift.

Red cell antigens [A,B,H,C,c,C(w),D,E,e,M,N,S,s,P1,K,FY(a),JK(a)] and 20 serum proteins or erythrocyte enzymes were tested in a white isolate of the French West Indies (the island of St-Barthélémy). The genetic differentiation mainly due to genetic drift and founder effect between France and this isolate and between the Leeward (parish of Gustavia) and Windward (parish of Lorient) areas within the island is discussed. Genetic admixture with black populations of African origin is very low.

ABO Blood-Group System

Definition in man of a polymorphic system of the normal colonic secretions.

A study conducted in 30 normal human colons, obtained from cadaveric kidney donors, has evidenced the presence of two polymorphic antigenic specificities, W and Z, in the secretory cells of the colon mucosa. Three phenotypes have been demonstrated so far: W-Z- (frequency: 0.17), W-Z+ (frequency: 0.23), and W+Z+ (frequency: 0.60). Specific anti-WZ and anti-W alloantibodies, independent of anti-A and B agglutinins, were found in normal sera from blood donors. No apparent correlation was found between the WZ specificities and the ABH Lewis specificities, the other blood group systems specificities, and the leucocyte group (HL-A) specificities.

Blood Group Antigens