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S Lavertu

Publications and source records attributed to S Lavertu.

2 recordsLinked to original sources
PubMed2000

Observation study of electronic portal images for off-line verification.

PURPOSE: The goals of this study were to evaluate the use of electronic portal imaging device (EPID) paper images as off-line verification tools and to assess the feasibility of replacing portal films by EPID printed images. MATERIALS AND METHODS: Electronic portal images were acquired using a video-based imaging system. After contrast enhancement, these images were printed and compared to portal films when prescribed, and judged about their usefulness for off-line verification. A total of 2025 images were acquired from 322 fields on 137 patients. The images were shown to eight radiation oncologists and two senior residents in radiation oncology, each one of them judging fields relevant to his (her) daily practice. The questions asked were related to the choice of important anatomical structures and the visibility of such structures, the usefulness of the printed images, the comparison with portal films and the possible replacement of such films by paper images. RESULTS: Answers to the different questions were treated as quantitative scores. For the visibility question, means and standard deviations were calculated for each individual structure, then a global score was obtained for a given treatment site. Means and standard deviations were also computed for the comparison question. Proportions and confidence intervals were used for the other questions. The results show that EPID paper images are useful for some treatment sites such as breast, thorax, prostate, abdomen, pelvis (other than rectum) and axilla. The image quality remains insufficient for some other sites such as head and neck and spine. CONCLUSION: Although global anatomical landmarks scores are good, the usefulness score is not always as high because some essential anatomical structures scores must be taken into account. There is also a strong habit factor related to acceptance of EPID printed images as verification tools. As long as they see more and more images, radiation oncologists can more easily visualize anatomical structures and are less stringent when evaluating the efficiency of EPID paper images as off-line verification tools.

Electronics, Medical↗
PubMed1999

Local failure is responsible for the decrease in survival for patients with breast cancer treated with conservative surgery and postoperative radiotherapy.

PURPOSE: The aim of the present study was to evaluate the role of local failure (LF) in the survival of patients treated with lumpectomy and postoperative radiotherapy and to investigate whether LF is not only a marker for distant metastasis (DM) but also a cause. METHODS: Charts of patients treated with breast conservative surgery between 1969 and 1991 were reviewed retrospectively. There were 2,030 patients available for analysis. The median duration of follow-up was 6 years. A Cox regression multivariate analysis was performed using LF as a time-dependent covariate. RESULTS: Local control (LC) was 87% at 10 years. Local failure led to poorer survival at 10 years than local control (55% v 75%, P < .00). In a Cox model, local failure was a powerful predictor of mortality. The relative risk associated with LF was 3.6 for mortality and 5.1 for DM (P < .00). In patients with LF, the rate of DM peaked at 5 to 6 years, whereas it peaked at 2 years for patients with LC. The mean time between surgery and DM was 1,050 days for patients without LF and 1,650 days for patients with LF (P < .00). CONCLUSION: Our results show that local failure is associated with an increase in mortality. The difference in the time distribution of distant metastasis for LF and LC could imply distinct mechanisms of dissemination. Local failure should be considered not only as a marker of occult circulating distant metastases but also as a source for new distant metastases and subsequent mortality.

Actuarial Analysis↗